Additional file 13 of Receptor deorphanization in an echinoderm reveals kisspeptin evolution and relationship with SALMFamide neuropeptides

Additional file 13. Sequences of chordate kisspeptin-type precursors (A) and precursors of neuropeptides that are candidate ligands for kisspeptin-type receptors in echinoderms (B-D). The N-terminal signal peptide is shown in blue, the neuropeptides predicted or shown to be derived from these proteins are shown in red (with the C-terminal glycine that is a substrate for amidation shown in orange) and monobasic or dibasic cleavage sites are shown in green. The neuropeptides (red) are named in accordance with the precursor they are derived from and their relative position in the precursor, which explains the nomenclature used in Fig. 3. Species names are abbreviated as follows: Hs, Homo sapiens, Lo, Lepisosteus oculatus, Bf, Branchiostoma floridae; Ar, Asterias rubens; Sp, Strongylocentrotus purpuratus; Aj, Apostichopus japonicus.