Additional file 20 of Receptor deorphanization in an echinoderm reveals kisspeptin evolution and relationship with SALMFamide neuropeptides

  • Nayeli Escudero Castelán (Creator)
  • Dean C. Semmens (Creator)
  • Luis Alfonso Yañez-Guerra (Creator)
  • Meet Zandawala (Creator)
  • Mario dos Reis (Creator)
  • Susan E. Slade (Creator)
  • James H. Scrivens (University of Warwick) (Creator)
  • Cleidiane G. Zampronio (Creator)
  • Alexandra M. Jones (Creator)
  • Olivier Mirabeau (Creator)
  • Maurice R. Elphick (Creator)



Additional file 20. A. Concentration-response graph comparing the potency/efficacy of S2 (S2.3; EC50 = 2.93 x 10-8 M) and a ‘cocktail’ of neuropeptides derived from the F-type SALMFamide precursor (EC50 = 1.33 × 10-9 M) as ligands for ArKPR6. B. Concentration-response graph comparing the potency and efficacy of S1 (S1.4; EC50 = 4.79 x 10-9 M) and a ‘cocktail’ of neuropeptides derived from the L-type SALMFamide precursor (EC50 = 2.43 × 10-9 M) as ligands for ArKPR7. Each point represents mean values (± S.E.M.) from at least four independent experiments, with each experiment performed in triplicate. Luminescence is expressed as a percentage of the maximal response observed in each experiment. The source data for these experiments are provided in additional file 15.
Date made available2022

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