Additional file 4 of Receptor deorphanization in an echinoderm reveals kisspeptin evolution and relationship with SALMFamide neuropeptides

  • Nayeli Escudero Castelán (Creator)
  • Dean C. Semmens (Creator)
  • Luis Alfonso Yañez-Guerra (Creator)
  • Meet Zandawala (Creator)
  • Mario dos Reis (Creator)
  • Susan E. Slade (Creator)
  • James H. Scrivens (University of Warwick) (Creator)
  • Cleidiane G. Zampronio (Creator)
  • Alexandra M. Jones (Creator)
  • Olivier Mirabeau (Creator)
  • Maurice R. Elphick (Creator)



Additional file 4. Phylogenetic analysis of bilaterian kisspeptin-type receptors, including expanded receptor families in the starfish A. rubens (ArubKPR1-11), other echinoderms, and Branchiostoma floridae. The phylogenetic tree was constructed using the maximum-likelihood method, LG+G4 amino-acid substitution model, and rooted with galanin/allatostatin-A-type receptors as an outgroup. Boostrap support for each node is stated according to SH-aLRT/UFBoot methods. The scale bar indicates amino acid substitutions per site. Species names are as follows: Apla, Acanthaster planci; Ajap, Apostichopus japonicus; Arub, Asterias rubens, Anjap Annessia japonica; Bbel, Branchiostoma belcheri; Bflo B. floridae; Ctel, Capitella teleta; Cgig, Crassostrea gigas; Hsap, Homo sapines; Lcha, Latimeria chalumnae; Locu, Lepisosteus oculatus; Lgig, Lottia gigantea; Mmus, Mus musculus; Pdum, Platynereis dumerilii; Pbiv, Python bivittatus; Skow, Saccoglossus kowalevskii; Spur, Strongylocentrotus purpuratus; Xlae Xenopus laevis; Xtro, X. tropicalis. Accession numbers for the sequences of the receptors included in this tree are listed in additional file 3.
Date made available2022

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