Additional file 7 of Receptor deorphanization in an echinoderm reveals kisspeptin evolution and relationship with SALMFamide neuropeptides

  • Nayeli Escudero Castelán (Creator)
  • Dean C. Semmens (Creator)
  • Luis Alfonso Yañez-Guerra (Creator)
  • Meet Zandawala (Creator)
  • Mario dos Reis (Creator)
  • Susan E. Slade (Creator)
  • James H. Scrivens (University of Warwick) (Creator)
  • Cleidiane G. Zampronio (Creator)
  • Alexandra M. Jones (Creator)
  • Olivier Mirabeau (Creator)
  • Maurice R. Elphick (Creator)



Additional file 7. CLuster Analysis of Sequences (CLANS) of receptors identified by BLAST analysis of bilaterian proteomes using human and S. purpuratus kisspeptin-type receptors as queries. BLOSUM62 cluster map shows kisspeptin-type receptors, the closely related galanin/allatostatin-A-type receptors, and other neuropeptide receptor families: allatotropin/orexin, neuropeptide Y, tachykinin, somatostatin/allatostatin-C, CCHamide/gastrin-releasing peptide. Nodes are labelled with taxon-specific shapes and colors, as shown in the key. Connections represent BLAST relationships with a P value > 1e-40. All family names of receptors are labelled in the figure. The accession numbers for the receptors shown in this figure are provided in additional file 2.
Date made available2022

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