Additional file 8 of Receptor deorphanization in an echinoderm reveals kisspeptin evolution and relationship with SALMFamide neuropeptides

  • Nayeli Escudero Castelán (Creator)
  • Dean C. Semmens (Creator)
  • Luis Alfonso Yañez-Guerra (Creator)
  • Meet Zandawala (Creator)
  • Mario dos Reis (Creator)
  • Susan E. Slade (Creator)
  • James H. Scrivens (University of Warwick) (Creator)
  • Cleidiane G. Zampronio (Creator)
  • Alexandra M. Jones (Creator)
  • Olivier Mirabeau (Creator)
  • Maurice R. Elphick (Creator)



Additional file 8. CLuster Analysis of Sequences (CLANS) of A. rubens kisspeptin-type receptors (ArKPR1-11) and other kisspeptin-type receptors from bilaterian taxa. BLOSUM62 cluster map of kisspeptin-type receptors and the closely related galanin/allatostatin-A-type receptors. Nodes are labelled with taxon-specific shapes and colors, as shown in the key. Connections represent BLAST relationships with a P value > 1e-40. Galanin/allatostatin-A-type receptors are enclosed within the dashed line. Names shown in dark blue with an associated symbol containing a blue dot are the receptors for which neuropeptide ligands have been identified experimentally in this study or others. Names shown in black with an associated symbol containing a black dot are A. rubens kisspeptin-type receptors for which neuropeptide ligands have yet to be identified. The accession numbers for the receptors shown in this figure are provided in additional file 3.
Date made available2022

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