Projects per year
Personal profile
Academic Biography
Dr. Ahmad Khundakar is a Senior Lecturer at Teesside University and Associate Lecturer at the Institute of Neuroscience, Newcastle University. He has a broad base of expertise in biomedical science and neuroscience and has published and presented extensively in neuropharmacology and neuropathology.
Learning and Teaching Interests and Activities
Dr. Khundakar currently leads the BSc (hons) Biomedical Science programme and teaches in pathology, pharmacology and neuroscience. He is a Fellow of the Institute for Biomedical Science and the Higher Education Academy.
Summary of Research Interests
Dr. Khundakar's research mainly involves investigating the molecular and pathological mechanisms behind neurodegerative illnesses, such as Alzheimer’s disease (AD), dementia with Lewy bodies (DLB) and Parkinson's disease (PD), as well as depression.
Dr. Khundakar previously supervised a National Institute for Health Research-funded laboratory-based PhD project examining the role of the thalamus in visual hallucinations in DLB and is currently co-supervisor of a laboratory-based Alzheimer's Society-funded Doctoral Training Centre PhD project. He also has expertise in neuropharmacology, with his PhD focusing on the mechanisms of action of antidepressant drugs in the hippocampus.
Based at the National Horizons Centre, Darlington, Dr. Khundakar's current research aims to identify key post-translation modifications in the pathological hallmarks of proteinopathies, such as AD, DLB and PD, using Raman microscopy, immunohistochemistry, liquid chromatography mass spectrometry (LC-MS/MS), enzyme-linked immunosorbent assay (ELISA) and immunoblot techniques.
Research Projects & External Funding
Co-investigator. 2015–2019. ‘Understanding the basis and interaction of non-cognitive and cognitive symptoms in dementia with Lewy bodies’. Alzheimer’s Society Doctoral Training Centre Grant. £350,000. Applicants: Thomas AJ, Morris CM, Attems JA, Khundakar AA, Taylor JP, Rochester L, LeBeau F, Blamire A, Galna B, Gallacher P.
External Research Collaborations
Dr. Khundakar is part of the Neurodegenerative Pathology Research Group at Newcastle University.
External Roles and Professional Activities
Associate Editor 'Frontiers in Psychiatry'
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Projects
- 1 Finished
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An examination of phosphoproteome patterns in a-synuclein using liquid chromatography-tandem mass spectrometry
1/06/22 → 30/11/22
Project: Research
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Specific patterns of neuronal loss in the pulvinar nucleus in dementia with lewy bodies
Erskine, D., Thomas, A. J., Attems, J., Taylor, J. P., McKeith, I. G., Morris, C. M. & Khundakar, A., 1 Mar 2017, In: Movement Disorders. 32, 3, p. 414-422 9 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile3 Citations (Scopus)258 Downloads (Pure) -
Stereological approaches to dementia research using human brain tissue
Erskine, D. & Khundakar, A., 1 Oct 2016, In: Journal of Chemical Neuroanatomy. 76, p. 73-81 9 p.Research output: Contribution to journal › Article › peer-review
File2 Citations (Scopus)181 Downloads (Pure) -
Doublecortin expression in CD8+ T-cells and microglia at sites of amyloid-β plaques: A potential role in shaping plaque pathology?
Unger, M. S., Marschallinger, J., Kaindl, J., Klein, B., Johnson, M., Khundakar, A., Roßner, S., Heneka, M. T., Couillard-Despres, S., Rockenstein, E., Masliah, E., Attems, J. & Aigner, L., 31 Aug 2018, In: Alzheimer's and Dementia. 14, 8, p. 1022-1037 16 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile3 Citations (Scopus)322 Downloads (Pure) -
Neuropathology of depression in Alzheimer's disease: Current knowledge and the potential for new treatments
Khundakar, A. A. & Thomas, A. J., 1 Jan 2015, In: Journal of Alzheimer's Disease. 44, 1, p. 27-41 15 p.Research output: Contribution to journal › Review article › peer-review
28 Citations (Scopus) -
Analysis of primary visual cortex in dementia with Lewy bodies indicates GABAergic involvement associated with recurrent complex visual hallucinations
Khundakar, A., Hanson, P. S., Erskine, D., Lax, N. Z., Roscamp, J., Karyka, E., Tsefou, E., Singh, P., Cockell, S. J., Gribben, A., Ramsay, L., Blain, P. G., Mosimann, U. P., Lett, D. J., Elstner, M., Turnbull, D. M., Xiang, C. C., Brownstein, M. J., O'Brien, J. T., Taylor, J. P., & 4 others, 1 Jan 2016, In: Acta neuropathologica communications. 4, 1, 66.Research output: Contribution to journal › Article › peer-review
File14 Citations (Scopus)137 Downloads (Pure)