20062019

Research output per year

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Personal profile

Academic Biography

Dr. Ahmad Khundakar is a Senior Lecturer at Teesside University and Associate Lecturer at the Institute of Neuroscience, Newcastle University. He has a broad base of expertise in biomedical science and neuroscience and has published and presented extensively in neuropharmacology and neuropathology.

Learning and Teaching Interests and Activities

Dr. Khundakar currently leads the BSc (hons) Biomedical Science programme and teaches in pathology, pharmacology and neuroscience. He is a Fellow of the Institute for Biomedical Science and the Higher Education Academy. 

Summary of Research Interests

Dr. Khundakar's research mainly involves investigating the molecular and pathological mechanisms behind neurodegerative illnesses, such as Alzheimer’s disease (AD), dementia with Lewy bodies (DLB) and Parkinson's disease (PD), as well as depression. 

Dr. Khundakar previously supervised a National Institute for Health Research-funded laboratory-based PhD project examining the role of the thalamus in visual hallucinations in DLB and is currently co-supervisor of a laboratory-based Alzheimer's Society-funded Doctoral Training Centre PhD project. He also has expertise in neuropharmacology, with his PhD focusing on the mechanisms of action of antidepressant drugs in the hippocampus.

Based at the National Horizons Centre, Darlington, Dr. Khundakar's current research aims to identify key post-translation modifications in the pathological hallmarks of proteinopathies, such as AD, DLB and PD, using Raman microscopy, immunohistochemistry, liquid chromatography mass spectrometry (LC-MS/MS), enzyme-linked immunosorbent assay (ELISA) and immunoblot techniques. 

Research Projects & External Funding

Co-investigator. 2015–2019. ‘Understanding the basis and interaction of non-cognitive and cognitive symptoms in dementia with Lewy bodies’. Alzheimer’s Society Doctoral Training Centre Grant. £350,000. Applicants: Thomas AJ, Morris CM, Attems JA, Khundakar AA, Taylor JP, Rochester L, LeBeau F, Blamire A, Galna B, Gallacher P.

External Research Collaborations

Dr. Khundakar is part of the Neurodegenerative Pathology Research Group at Newcastle University.

https://research.ncl.ac.uk/ndprg/

External Roles and Professional Activities

Associate Editor 'Frontiers in Psychiatry' 

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Research Output

Specific patterns of neuronal loss in the pulvinar nucleus in dementia with lewy bodies

Erskine, D., Thomas, A. J., Attems, J., Taylor, J. P., McKeith, I. G., Morris, C. M. & Khundakar, A., 1 Mar 2017, In : Movement Disorders. 32, 3, p. 414-422 9 p.

Research output: Contribution to journalArticle

Open Access
File
  • 3 Citations (Scopus)
    181 Downloads (Pure)

    Stereological approaches to dementia research using human brain tissue

    Erskine, D. & Khundakar, A., 1 Oct 2016, In : Journal of Chemical Neuroanatomy. 76, p. 73-81 9 p.

    Research output: Contribution to journalArticle

    File
  • 2 Citations (Scopus)
    177 Downloads (Pure)

    Doublecortin expression in CD8+ T-cells and microglia at sites of amyloid-β plaques: A potential role in shaping plaque pathology?

    Unger, M. S., Marschallinger, J., Kaindl, J., Klein, B., Johnson, M., Khundakar, A., Roßner, S., Heneka, M. T., Couillard-Despres, S., Rockenstein, E., Masliah, E., Attems, J. & Aigner, L., 31 Aug 2018, In : Alzheimer's and Dementia. 14, 8, p. 1022-1037 16 p.

    Research output: Contribution to journalArticle

    Open Access
    File
  • 3 Citations (Scopus)
    203 Downloads (Pure)

    Neuropathology of depression in Alzheimer's disease: Current knowledge and the potential for new treatments

    Khundakar, A. A. & Thomas, A. J., 1 Jan 2015, In : Journal of Alzheimer's Disease. 44, 1, p. 27-41 15 p.

    Research output: Contribution to journalReview article

  • 28 Citations (Scopus)

    Analysis of primary visual cortex in dementia with Lewy bodies indicates GABAergic involvement associated with recurrent complex visual hallucinations

    Khundakar, A., Hanson, P. S., Erskine, D., Lax, N. Z., Roscamp, J., Karyka, E., Tsefou, E., Singh, P., Cockell, S. J., Gribben, A., Ramsay, L., Blain, P. G., Mosimann, U. P., Lett, D. J., Elstner, M., Turnbull, D. M., Xiang, C. C., Brownstein, M. J., O'Brien, J. T., Taylor, J. P. & 4 others, Attems, J., Thomas, A. J., McKeith, I. G. & Morris, C. M., 1 Jan 2016, In : Acta neuropathologica communications. 4, 1, 66.

    Research output: Contribution to journalArticle

    File
  • 14 Citations (Scopus)
    130 Downloads (Pure)

    Press / Media

    Dementia conference features Newcastle academics

    Ahmad Khundakar

    20/03/14

    1 item of Media coverage

    Press/Media: Press / Media

    Alzheimer's conference

    Ahmad Khundakar

    19/03/14

    1 item of Media coverage

    Press/Media: Press / Media

    Undergraduate bursaries to encourage careers in dementia research

    Ahmad Khundakar

    3/06/14

    1 item of Media coverage

    Press/Media: Press / Media

    Newcastle experts to address national dementia meeting

    Ahmad Khundakar

    19/03/14

    1 item of Media coverage

    Press/Media: Press / Media