Projects per year
Personal profile
Academic Biography
As a Scientific Officer working at National Horizons Centre (NHC), Claire specialises in using analytical chromatography and state-of-the-art mass spectrometry instrumentation to investigate and develop a variety of biomedical, biopharmaceutical and biotechnological research applications.
With a background in biomedical sciences, biochemistry and molecular biology, plus over 10 years post-doctoral experience, Claire has gained significant analytical expertise in qualitative and quantitative measurement of small molecules, metabolites, peptides and proteins within purified samples or complex biological matrices.
Claire joined NHC in 2021 and previously performed mass spectrometry to support fragment based drug discovery at the Newcastle University CRUK Drug Discovery Unit. In this post, she made significant data contributions towards the development of a Phase I/II candidate drug molecule (ASTX295) in collaboration with Astex Biopharmaceuticals.
Claire also worked in the Newcastle Cancer Centre Pharmacology Group, carrying out pharmacokinetic analysis to quantitate drug levels in patients undergoing chemotherapy during clinical trials.
Education/Academic qualification
PhD, Chromatographic Analysis of Recombinant Lysostaphin Expressed in E.coli, Northumbria University
2006 → 2011
Master, MRes in Molecular Biology, Northumbria University
2005 → 2006
Bachelor, BSc (Hons) in Biomedical Sciences (with First Class Honours) , Northumbria University
2002 → 2005
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Collaborations and top research areas from the last five years
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Assessing homologous recombination repair function in response to RAD51 inhibitor
Sharma Saha, S. (PI), Zhou, P. (RA), Karunakaran, K. (CoI) & Jennings, C. (RA)
1/06/22 → 31/05/25
Project: Research
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Novel approaches for the identification of alpha-synuclein modifications as potential biomarkers in melanoma
Philippou, P. F. (PI), Outeiro, T. F. (CoI), Khundakar, A. (CoI), Jennings, C. (CoI), Lenis, V. P. (CoI) & Angione, C. (CoI)
15/06/23 → 29/02/24
Project: Research
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Conformational investigation of charge heterogeneity through native analysis of monoclonal antibody fragments using High-Resolution Cyclic IM-MS
Jennings, C., Corbett, M., Kane-Fidgeon, J., Keen, J., Sharkey, D., Pettit, D. & Muck, A., 17 Jul 2023. 1 p.Research output: Contribution to conference › Poster
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Targeting Cytotoxic Agents through EGFR-Mediated Covalent Binding and Release
Morese, P., Anthony, N., Bodnarchuk, M., Jennings, C., Martin, M., Noble, R., Phillips, N., Thomas, H., Wang, L., Lister, A., Noble , M., Ward, R., Wedge, S., Stewart, H. & Waring, M., 30 Aug 2023, In: Journal of Medicinal Chemistry. 66, p. 12324-12341 17 p.Research output: Contribution to journal › Article › peer-review
Open Access -
An alkynylpyrimidine-based covalent inhibitor that targets a unique cysteine in NF-kB-inducing kinase (NIK)
Al-Khawaldeh, I., Jennings, C., Al Yasiri, M. J., Aldred, G. G., Basmadjian, C., Bordoni, C., Harnor, S. J., Heptinstall, A. B., Hobson, S. J., Khalifa, S., Lebraud, H., Martin, M. P., Miller, D. C., Shrives, H. J., de Souza, J. V., Stewart, H. L., Temple, M., Thomas, H. D., Totobenazara, J. & Tucker, J. A. & 12 others, , 2 Jul 2021, In: Journal of Medicinal Chemistry.Research output: Contribution to journal › Article › peer-review
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Dactinomycin induces complete remission associated with nucleolar stress response in relapsed/refractory NPM1-mutated AML
Gionfriddo, I., Brunetti, L., Mezzasoma, F., Milano, F., Cardinali, V., Ranieri, R., Venanzi, A., Perangeli, S., Vetro, C., Spinozzi, G., Dorillo, E., Wu, H. C., Berthier, C., Ciurnelli, R., Griffin, M. J., Jennings, C., Tiacci, E., Sportoletti, P., Falzetti, F. & de The, H. & 3 others, , 2 Mar 2021, In: Leukemia.Research output: Contribution to journal › Article › peer-review
Open AccessFile170 Downloads (Pure) -
Structure-Based Design of Potent and Orally Active Isoindolinone Inhibitors of MDM2-p53 Protein–Protein Interaction
Chessari, G., Hardcastle, I. R., Ahn, J. S., Anil, B., Anscombe, E., Bawn, R. H., Bevan, L. D., Blackburn, T. J., Buck, I., Cano, C., Carbain, B., Castro, J., Cons, B., Cully, S. J., Endicott, J. A., Fazal, L., Golding, B. T., Griffin, R. J., Haggerty, K. & Harnor, S. J. & 23 others, , 8 Apr 2021, In: Journal of Medicinal Chemistry. 64, 7, p. 4071-4088Research output: Contribution to journal › Article › peer-review