20052019
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Personal profile

Academic Biography

Dr Mina has a multidisciplinary background with wide expertise covering characterisation of identified drug targets (development and optimisation of activity assay, determination of kinetic parameters & catalysis model), design & synthesis of focused chemical libraries, designing & conducting ex-vivo and in-cellulo screens and assays, SAR analysis, molecular modelling and target validation.

Briefly, his first degree was BSc in Pharmacy and Pharmaceutical Sciences (Honours). Subsequently, he did his postgraduate studies; he obtained an MSc in organic synthesis of heterocycles followed by a PhD in Chemical Biology supported by the Overseas Research Students Award Scheme (ORSAS).

Immediately after finalising his PhD, he was the lead researcher in two academia-industry collaborative projects conducting an inhibitor screen against a promising drug target in Leishmania parasite (Durham University in collaboration with MRC-Technology and the Tres Cantos Open Lab Foundation, Spain, respectively) which gave him an extensive experience working with industrial partners and in industrial settings.

In 2012, he joined Imperial College London where he worked as a part of the PROXOMICS project, a £4.6 million multidisciplinary research programme between Imperial College London, University of Glasgow and Aston University funded by (EPSRC) to focus on the development of new tools and technologies for monitoring redox control and oxidative damage with potential applications in cancer therapy.  

Subsequently, in 2013, he was awarded the prestigious EU Marie-Curie Fellowship to carry out his own research project as a Research Fellow in the lab of Prof Holthuis at the University of Osnabrueck and Utrecht University. His research focused on the identification of ceramide effectors and their involvement in the induction of mitochondrial apoptosis.

In 2016, he relocated back to the UK and joined a collaborative project between University of Glasgow and Durham University where he used a combination of advanced genome editing (CRISPR, Cre recombinase), molecular and cellular biology, and biochemical & biophysical novel technique (e.g. cell-free expression of integral membrane proteins) to functionally characterise the key enzymes of sphingolipid biosynthesis and assess their tractability as potential drug targets in in the parasite Toxoplasma gondii.

Recently, he joined Teesside University as a lecturer in biomedical sciences where he is currently responsible of delivering and developing a multitude of modules that span both biology and chemistry.

Research interests

Dr Mina's research mainly focuses on developing novel platforms for the study of biomolecular interactions at organellar membranes using chemical probes, particularly the mitochondria, with potential applications and direct impact on developing new therapeutics especially in the field of coccidian parasitic infections.

Other research areas in the Mina Lab are aimed at studying:

  • [1] Host-pathogen interaction: Exchange of lipids.
  • [2] Non-vesicular lipid transport.
  • [3] Development of chemical toolboxes to study lipid interactions.
  • [4] Cell-free expression of (integral) membrane proteins.
  • [5] Biophysical and biochemical characterisation of (integral) membrane proteins.
  • [6] Investigating protein-ligand interactions using NMR.
  • [7] uHTS multiplexing assay design.

Academic Responsibilities

Dr Mina is currently teaching various modules spanning both disciplines of chemistry and biology:

  • [1] Introduction to Organic Chemistry (Yr1), Module leader
  • [2] Organic Chemistry 1 (Yr2), Module leader
  • [3] Organic Chemistry 2 (Yr3), Module leader
  • [4] Human Metabolism and Clinical Biochemistry (Yr2)
  • [5] Clinical Pharmacology (Yr2)
  • [6] Biochemistry and Chemical Science (Yr1)
  • [7] Medical Laboratory Science (Yr1)
  • [8] Investigations in Forensic Chemistry (Yr2)

Dr Mina is currently co-supervising several final year project students and two MSc Students with Dr Mosharaf Sarker.

External Roles and Professional Activities

Dr Mina is currently a visiting researcher at Durham University where his research on protozoan parasites, Leishmania spp. and Toxoplasma gondii is taking place in collaboration with Prof Patrick Steel and Dr Paul Denny.

PhD and Research Opportunities

- Students who are interested in joining the Mina lab are welcome to contact Dr Mina by email.

- PhD and PDRA positions will be advertised when available.

Education/Academic qualification

PhD, University of Durham

Master, University of Durham

Bachelor, Cairo University

External positions

Visiting Researcher, University of Durham

1 Oct 2018 → …

Fingerprint Fingerprint is based on mining the text of the person's scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

Sphingolipids Medicine & Life Sciences
Inositol Medicine & Life Sciences
Ceramides Medicine & Life Sciences
Enzymes Medicine & Life Sciences
Parasites Medicine & Life Sciences
Leishmania major Medicine & Life Sciences
Yeasts Medicine & Life Sciences
Leishmania Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output 2005 2019

  • 13 Article
  • 2 Meeting Abstract
  • 1 Conference article
  • 1 Review article
3 Downloads (Pure)

Ceramides bind VDAC2 to trigger mitochondrial apoptosis

Dadsena, S., Bockelmann, S., Mina, J. G. M., Hassan, D. G., Korneev, S., Razzera, G., Jahn, H., Niekamp, P., Müller, D., Schneider, M., Tafesse, F. G., Marrink, S. J., Melo, M. N. & Holthuis, J. C. M., 23 Apr 2019, In : Nature Communications. 10, 1, 1832.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Ceramides
apoptosis
glutamates
actuators
Apoptosis

A search for ceramide binding proteins using bifunctional lipid analogs yields CERT-related protein StarD7

Bockelmann, S., Mina, J. G. M., Korneev, S., Hassan, D. G., Mueller, D., Hilderink, A., Vlieg, H. C., Raijmakers, R., Heck, A. J. R., Haberkant, P. & Holthuis, J. C. M., 1 Mar 2018, In : Journal of Lipid Research. 59, 3, p. 515-530 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Ceramides
Carrier Proteins
Proteins
Lipids
Phosphatidylcholines
8 Downloads (Pure)

Everybody needs sphingolipids, right! Mining for new drug targets in protozoan sphingolipid biosynthesis

Mina, J. G. M. & Denny, P. W., 28 Feb 2018, In : Parasitology. 145, Special Issue 2, p. 134-147 14 p.

Research output: Contribution to journalConference articleResearchpeer-review

Open Access
File
sphingolipids
Sphingolipids
new drugs
Protozoa
biosynthesis

Identifying inhibitors of the Leishmania inositol phosphorylceramide synthase with antiprotozoal activity using a yeast-based assay and ultra-high throughput screening platform

Norcliffe, J. L., Mina, J. G., Alvarez, E., Cantizani, J., de Dios-Anton, F., Colmenarejo, G., Gonzalez-Del Valle, S., Marco, M., Fiandor, J. M., Martin, J. J., Steel, P. G. & Denny, P. W., 2 Mar 2018, In : Scientific Reports. 8, 3938, 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
High-Throughput Screening Assays
Leishmania
Inositol
Leishmaniasis
Yeasts
11 Downloads (Pure)

Tamoxifen inhibits the biosynthesis of inositolphosphorylceramide in Leishmania

Trinconi, C. T., Miguel, D. C., Silber, A. M., Brown, C., Mina, J. G. M., Denny, P. W., Heise, N. & Uliana, S. R. B., 25 Oct 2018, In : International Journal for Parasitology: Drugs and Drug Resistance. 8, 3, p. 475-487 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Leishmania
Tamoxifen
Inositol
Phosphatidylinositols
Glycerides