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Personal profile

Academic Biography

Dr Mina has a multidisciplinary background with wide expertise covering characterisation of identified drug targets (development and optimisation of activity assay, determination of kinetic parameters & catalysis model), design & synthesis of focused chemical libraries, designing & conducting ex-vivo and in-cellulo screens and assays, SAR analysis, molecular modelling and target validation.

Briefly, his first degree was BSc in Pharmacy and Pharmaceutical Sciences (Honours). Subsequently, he did his postgraduate studies; he obtained an MSc in organic synthesis of heterocycles followed by a PhD in Chemical Biology supported by the Overseas Research Students Award Scheme (ORSAS).

Immediately after finalising his PhD, he was the lead researcher in two academia-industry collaborative projects conducting an inhibitor screen against a promising drug target in Leishmania parasite (Durham University in collaboration with MRC-Technology and the Tres Cantos Open Lab Foundation, Spain, respectively) which gave him an extensive experience working with industrial partners and in industrial settings.

In 2012, he joined Imperial College London where he worked as a part of the PROXOMICS project, a £4.6 million multidisciplinary research programme between Imperial College London, University of Glasgow and Aston University funded by (EPSRC) to focus on the development of new tools and technologies for monitoring redox control and oxidative damage with potential applications in cancer therapy.  

Subsequently, in 2013, he was awarded the prestigious EU Marie-Curie Fellowship to carry out his own research project as a Research Fellow in the lab of Prof Holthuis at the University of Osnabrueck and Utrecht University. His research focused on the identification of ceramide effectors and their involvement in the induction of mitochondrial apoptosis.

In 2016, he relocated back to the UK and joined a collaborative project between University of Glasgow and Durham University where he used a combination of advanced genome editing (CRISPR, Cre recombinase), molecular and cellular biology, and biochemical & biophysical novel technique (e.g. cell-free expression of integral membrane proteins) to functionally characterise the key enzymes of sphingolipid biosynthesis and assess their tractability as potential drug targets in in the parasite Toxoplasma gondii.

Recently, he joined Teesside University as a lecturer in biomedical sciences where he is currently responsible of delivering and developing a multitude of modules that span both biology and chemistry.

Research interests

Dr Mina's research mainly focuses on developing novel platforms for the study of biomolecular interactions at organellar membranes using chemical probes, particularly the mitochondria, with potential applications and direct impact on developing new therapeutics especially in the field of coccidian parasitic infections.

Other research areas in the Mina Lab are aimed at studying:

  • [1] Host-pathogen interaction: Exchange of lipids.
  • [2] Non-vesicular lipid transport.
  • [3] Development of chemical toolboxes to study lipid interactions.
  • [4] Cell-free expression of (integral) membrane proteins.
  • [5] Biophysical and biochemical characterisation of (integral) membrane proteins.
  • [6] Investigating protein-ligand interactions using NMR.
  • [7] uHTS multiplexing assay design.

Academic Responsibilities

Dr Mina is currently teaching various modules spanning both disciplines of chemistry and biology:

  • [1] Introduction to Organic Chemistry (Yr1), Module leader
  • [2] Organic Chemistry 1 (Yr2), Module leader
  • [3] Organic Chemistry 2 (Yr3), Module leader
  • [4] Human Metabolism and Clinical Biochemistry (Yr2)
  • [5] Clinical Pharmacology (Yr2)
  • [6] Biochemistry and Chemical Science (Yr1)
  • [7] Medical Laboratory Science (Yr1)
  • [8] Investigations in Forensic Chemistry (Yr2)

Dr Mina is currently co-supervising several final year project students and two MSc Students with Dr Mosharaf Sarker.

External Roles and Professional Activities

Dr Mina is currently a visiting researcher at Durham University where his research on protozoan parasites, Leishmania spp. and Toxoplasma gondii is taking place in collaboration with Prof Patrick Steel and Dr Paul Denny.

PhD and Research Opportunities

- Students who are interested in joining the Mina lab are welcome to contact Dr Mina by email.

- PhD and PDRA positions will be advertised when available.

Education/Academic qualification

PhD, Durham University

Award Date: 1 Aug 2010

Master, Durham University

Award Date: 1 Jan 2005

Bachelor, Cairo University

Award Date: 1 Aug 2000

External positions

Visiting Researcher, Durham University

1 Oct 2018 → …


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