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Research Output

  • 14 Article
  • 2 Meeting Abstract
  • 1 Conference article
  • 1 Review article
2019

Ceramides bind VDAC2 to trigger mitochondrial apoptosis

Dadsena, S., Bockelmann, S., Mina, J. G. M., Hassan, D. G., Korneev, S., Razzera, G., Jahn, H., Niekamp, P., Müller, D., Schneider, M., Tafesse, F. G., Marrink, S. J., Melo, M. N. & Holthuis, J. C. M., 23 Apr 2019, In : Nature Communications. 10, 1, 1832.

Research output: Contribution to journalArticle

Open Access
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120 Downloads (Pure)

The identification of small molecule inhibitors of the plant inositol phosphorylceramide synthase which demonstrate herbicidal activity

Pinneh, E. C., Mina, J. G., Stark, M. J. R., Lindell, S. D., Luemmen, P., Knight, M. R., Steel, P. G. & Denny, P. W., 1 Dec 2019, In : Scientific Reports. 9, 1, 8083.

Research output: Contribution to journalArticle

Open Access
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86 Downloads (Pure)
2018

A search for ceramide binding proteins using bifunctional lipid analogs yields CERT-related protein StarD7

Bockelmann, S., Mina, J. G. M., Korneev, S., Hassan, D. G., Mueller, D., Hilderink, A., Vlieg, H. C., Raijmakers, R., Heck, A. J. R., Haberkant, P. & Holthuis, J. C. M., 1 Mar 2018, In : Journal of Lipid Research. 59, 3, p. 515-530 16 p.

Research output: Contribution to journalArticle

Everybody needs sphingolipids, right! Mining for new drug targets in protozoan sphingolipid biosynthesis

Mina, J. G. M. & Denny, P. W., 28 Feb 2018, In : Parasitology. 145, Special Issue 2, p. 134-147 14 p.

Research output: Contribution to journalConference article

Open Access
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132 Downloads (Pure)

Identifying inhibitors of the Leishmania inositol phosphorylceramide synthase with antiprotozoal activity using a yeast-based assay and ultra-high throughput screening platform

Norcliffe, J. L., Mina, J. G., Alvarez, E., Cantizani, J., de Dios-Anton, F., Colmenarejo, G., Gonzalez-Del Valle, S., Marco, M., Fiandor, J. M., Martin, J. J., Steel, P. G. & Denny, P. W., 2 Mar 2018, In : Scientific Reports. 8, 3938, 10 p.

Research output: Contribution to journalArticle

Open Access

Tamoxifen inhibits the biosynthesis of inositolphosphorylceramide in Leishmania

Trinconi, C. T., Miguel, D. C., Silber, A. M., Brown, C., Mina, J. G. M., Denny, P. W., Heise, N. & Uliana, S. R. B., 25 Oct 2018, In : International Journal for Parasitology: Drugs and Drug Resistance. 8, 3, p. 475-487 13 p.

Research output: Contribution to journalArticle

Open Access
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124 Downloads (Pure)
2017

ER residency of the ceramide phosphoethanolamine synthase SMSr relies on homotypic oligomerization mediated by its SAM domain

Cabukusta, B., Kol, M., Kneller, L., Hilderink, A., Bickert, A., Mina, J. G. M., Korneev, S. & Holthuis, J. C. M., 25 Jan 2017, In : Scientific Reports. 7, 17 p.

Research output: Contribution to journalArticle

Open Access
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126 Downloads (Pure)

Functional and phylogenetic evidence of a bacterial origin for the first enzyme in sphingolipid biosynthesis in a phylum of eukaryotic protozoan parasites

Mina, J. G., Thye, J. K., Alqaisi, A. Q. I., Bird, L. E., Dods, R. H., Groftehauge, M. K., Mosely, J. A., Pratt, S., Shams-Eldin, H., Schwarz, R. T., Pohl, E. & Denny, P. W., 21 Jul 2017, In : Journal of Biological Chemistry. 292, 29, p. 12208-12219 12 p.

Research output: Contribution to journalArticle

Open Access
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145 Downloads (Pure)

Switching head group selectivity in mammalian sphingolipid biosynthesis by active-site-engineering of sphingomyelin synthases

Kol, M., Panatala, R., Nordmann, M., Swart, L., van Suijlekom, L., Cabukusta, B., Hilderink, A., Grabietz, T., Mina, J. G. M., Somerharju, P., Korneev, S., Tafesse, F. G. & Holthuis, J. C. M., 23 May 2017, In : Journal of Lipid Research. 58, 5, p. 962-973 12 p.

Research output: Contribution to journalArticle

Open Access
File
112 Downloads (Pure)
2015

Molecular dissection of ceramide-induced apoptosis using bifunctional lipid analogs

Bockelmann, S., Mina, J., Jain, A., Ehring, K., Korneev, S. & Holthuis, J. C. M., 1 Jul 2015, In : FEBS Journal. 282, 1, SI, p. 399 1 p.

Research output: Contribution to journalMeeting Abstract

2014

Inhibitors of Leishmania major inositol phosphorylceramide synthase: New therapies for leishmaniasis

Brown, C., Mina, J. G. M., Steel, P. G., Denny, P. W. & Merritt, A. T., 10 Aug 2014, In : ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. 248

Research output: Contribution to journalMeeting Abstract

2013

Sphingolipid synthesis and scavenging in the intracellular apicomplexan parasite, Toxoplasma gondii

Pratt, S., Wansadhipathi-Kannangara, N. K., Bruce, C. R., Mina, J. G., Shams-Eldin, H., Casas, J., Hanada, K., Schwarz, R. T., Sonda, S. & Denny, P. W., 1 Jan 2013, In : Molecular and Biochemical Parasitology. 187, 1, p. 43-51 9 p.

Research output: Contribution to journalArticle

Open Access
2012

Sphingolipid and ceramide homeostasis: Potential therapeutic targets

Young, S. A., Mina, J. G., Denny, P. W. & Smith, T. K., 21 Mar 2012, In : Biochemistry Research International. 248135.

Research output: Contribution to journalReview article

Open Access
26 Citations (Scopus)
2011

Exploring Leishmania major Inositol Phosphorylceramide Synthase (LmjIPCS): Insights into the ceramide binding domain

Mina, J. G., Mosely, J. A., Ali, H. Z., Denny, P. W. & Steel, P. G., 2011, In : Organic and Biomolecular Chemistry. 9, 6, p. 1823-1830 8 p.

Research output: Contribution to journalArticle

2010

A plate-based assay system for analyses and screening of the Leishmania major inositol phosphorylceramide synthase

Mina, J. G., Mosely, J. A., Ali, H. Z., Shams-Eldin, H., Schwarz, R. T., Steel, P. G. & Denny, P. W., 1 Sep 2010, In : International Journal of Biochemistry and Cell Biology. 42, 9, p. 1553-1561 9 p.

Research output: Contribution to journalArticle

Functional analyses of differentially expressed isoforms of the Arabidopsis inositol phosphorylceramide synthase

Mina, J. G., Okada, Y., Wansadhipathi-Kannangara, N. K., Pratt, S., Shams-Eldin, H., Schwarz, R. T., Steel, P. G., Fawcett, T. & Denny, P. W., 1 Jul 2010, In : Plant Molecular Biology. 73, 4-5, p. 399-407 9 p.

Research output: Contribution to journalArticle

2009

The Trypanosoma brucei sphingolipid synthase, an essential enzyme and drug target

Mina, J. G., Pan, S-Y., Wansadhipathi, N. K., Bruce, C. R., Shams-Eldin, H., Schwarz, R. T., Steel, P. G. & Denny, P. W., 1 Nov 2009, In : Molecular and Biochemical Parasitology. 168, 1, p. 16-23 8 p.

Research output: Contribution to journalArticle

2005

A tandem C-H insertion-acetal cleavage sequence: stereocontrolled synthesis of substituted tetrahydrofurans

Garbi, A., Mina, JG., Steel, PG., Longstaff, T. & Vile, S., 17 Oct 2005, In : Tetrahedron Letters. 46, 42, p. 7175-7178 4 p.

Research output: Contribution to journalArticle