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John Mina

Dr

 https://orcid.org/0000-0003-0429-1370
20052019
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Research Output 2005 2019

  • 14 Article
  • 2 Meeting Abstract
  • 1 Conference article
  • 1 Review article
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Article
2019
53 Downloads (Pure)

Ceramides bind VDAC2 to trigger mitochondrial apoptosis

Dadsena, S., Bockelmann, S., Mina, J. G. M., Hassan, D. G., Korneev, S., Razzera, G., Jahn, H., Niekamp, P., Müller, D., Schneider, M., Tafesse, F. G., Marrink, S. J., Melo, M. N. & Holthuis, J. C. M., 23 Apr 2019, In : Nature Communications. 10, 1, 1832.

Research output: Contribution to journal › Article

Open Access
File
Ceramides
apoptosis
glutamates
actuators
Apoptosis
31 Downloads (Pure)

The identification of small molecule inhibitors of the plant inositol phosphorylceramide synthase which demonstrate herbicidal activity

Pinneh, E. C., Mina, J. G., Stark, M. J. R., Lindell, S. D., Luemmen, P., Knight, M. R., Steel, P. G. & Denny, P. W., 1 Dec 2019, In : Scientific Reports. 9, 1, 8083.

Research output: Contribution to journal › Article

Open Access
File
Herbicides
Inositol
Yeasts
Arabidopsis
Enzymes
2018

A search for ceramide binding proteins using bifunctional lipid analogs yields CERT-related protein StarD7

Bockelmann, S., Mina, J. G. M., Korneev, S., Hassan, D. G., Mueller, D., Hilderink, A., Vlieg, H. C., Raijmakers, R., Heck, A. J. R., Haberkant, P. & Holthuis, J. C. M., 1 Mar 2018, In : Journal of Lipid Research. 59, 3, p. 515-530 16 p.

Research output: Contribution to journal › Article

Ceramides
Carrier Proteins
Proteins
Lipids
Phosphatidylcholines

Identifying inhibitors of the Leishmania inositol phosphorylceramide synthase with antiprotozoal activity using a yeast-based assay and ultra-high throughput screening platform

Norcliffe, J. L., Mina, J. G., Alvarez, E., Cantizani, J., de Dios-Anton, F., Colmenarejo, G., Gonzalez-Del Valle, S., Marco, M., Fiandor, J. M., Martin, J. J., Steel, P. G. & Denny, P. W., 2 Mar 2018, In : Scientific Reports. 8, 3938, 10 p.

Research output: Contribution to journal › Article

Open Access
High-Throughput Screening Assays
Leishmania
Inositol
Leishmaniasis
Yeasts
60 Downloads (Pure)

Tamoxifen inhibits the biosynthesis of inositolphosphorylceramide in Leishmania

Trinconi, C. T., Miguel, D. C., Silber, A. M., Brown, C., Mina, J. G. M., Denny, P. W., Heise, N. & Uliana, S. R. B., 25 Oct 2018, In : International Journal for Parasitology: Drugs and Drug Resistance. 8, 3, p. 475-487 13 p.

Research output: Contribution to journal › Article

Open Access
File
Leishmania
Tamoxifen
Inositol
Phosphatidylinositols
Glycerides
2017
58 Downloads (Pure)

ER residency of the ceramide phosphoethanolamine synthase SMSr relies on homotypic oligomerization mediated by its SAM domain

Cabukusta, B., Kol, M., Kneller, L., Hilderink, A., Bickert, A., Mina, J. G. M., Korneev, S. & Holthuis, J. C. M., 25 Jan 2017, In : Scientific Reports. 7, 17 p.

Research output: Contribution to journal › Article

Open Access
File
Ceramides
Internship and Residency
Enzymes
Homeostasis
Diacylglycerol Kinase
62 Downloads (Pure)

Functional and phylogenetic evidence of a bacterial origin for the first enzyme in sphingolipid biosynthesis in a phylum of eukaryotic protozoan parasites

Mina, J. G., Thye, J. K., Alqaisi, A. Q. I., Bird, L. E., Dods, R. H., Groftehauge, M. K., Mosely, J. A., Pratt, S., Shams-Eldin, H., Schwarz, R. T., Pohl, E. & Denny, P. W., 21 Jul 2017, In : Journal of Biological Chemistry. 292, 29, p. 12208-12219 12 p.

Research output: Contribution to journal › Article

Open Access
File
Serine C-Palmitoyltransferase
Sphingolipids
Biosynthesis
Parasites
Apicomplexa
60 Downloads (Pure)

Switching head group selectivity in mammalian sphingolipid biosynthesis by active-site-engineering of sphingomyelin synthases

Kol, M., Panatala, R., Nordmann, M., Swart, L., van Suijlekom, L., Cabukusta, B., Hilderink, A., Grabietz, T., Mina, J. G. M., Somerharju, P., Korneev, S., Tafesse, F. G. & Holthuis, J. C. M., 23 May 2017, In : Journal of Lipid Research. 58, 5, p. 962-973 12 p.

Research output: Contribution to journal › Article

Open Access
File
Sphingolipids
Biosynthesis
Catalytic Domain
Enzymes
Cell membranes
2013

Sphingolipid synthesis and scavenging in the intracellular apicomplexan parasite, Toxoplasma gondii

Pratt, S., Wansadhipathi-Kannangara, N. K., Bruce, C. R., Mina, J. G., Shams-Eldin, H., Casas, J., Hanada, K., Schwarz, R. T., Sonda, S. & Denny, P. W., 1 Jan 2013, In : Molecular and Biochemical Parasitology. 187, 1, p. 43-51 9 p.

Research output: Contribution to journal › Article

Open Access
Sphingolipids
Toxoplasma
Inositol
Parasites
Yeasts
2011

Exploring Leishmania major Inositol Phosphorylceramide Synthase (LmjIPCS): Insights into the ceramide binding domain

Mina, J. G., Mosely, J. A., Ali, H. Z., Denny, P. W. & Steel, P. G., 2011, In : Organic and Biomolecular Chemistry. 9, 6, p. 1823-1830 8 p.

Research output: Contribution to journal › Article

inositols
Leishmania major
Ceramides
Inositol
affinity
2010

A plate-based assay system for analyses and screening of the Leishmania major inositol phosphorylceramide synthase

Mina, J. G., Mosely, J. A., Ali, H. Z., Shams-Eldin, H., Schwarz, R. T., Steel, P. G. & Denny, P. W., 1 Sep 2010, In : International Journal of Biochemistry and Cell Biology. 42, 9, p. 1553-1561 9 p.

Research output: Contribution to journal › Article

Leishmania major
Inositol
Systems Analysis
Assays
Screening

Functional analyses of differentially expressed isoforms of the Arabidopsis inositol phosphorylceramide synthase

Mina, J. G., Okada, Y., Wansadhipathi-Kannangara, N. K., Pratt, S., Shams-Eldin, H., Schwarz, R. T., Steel, P. G., Fawcett, T. & Denny, P. W., 1 Jul 2010, In : Plant Molecular Biology. 73, 4-5, p. 399-407 9 p.

Research output: Contribution to journal › Article

Inositol
Arabidopsis
sphingolipids
Protein Isoforms
Sphingolipids
2009

The Trypanosoma brucei sphingolipid synthase, an essential enzyme and drug target

Mina, J. G., Pan, S-Y., Wansadhipathi, N. K., Bruce, C. R., Shams-Eldin, H., Schwarz, R. T., Steel, P. G. & Denny, P. W., 1 Nov 2009, In : Molecular and Biochemical Parasitology. 168, 1, p. 16-23 8 p.

Research output: Contribution to journal › Article

Essential Drugs
Trypanosoma brucei brucei
Sphingolipids
Inositol
Parasites
2005

A tandem C-H insertion-acetal cleavage sequence: stereocontrolled synthesis of substituted tetrahydrofurans

Garbi, A., Mina, JG., Steel, PG., Longstaff, T. & Vile, S., 17 Oct 2005, In : Tetrahedron Letters. 46, 42, p. 7175-7178 4 p.

Research output: Contribution to journal › Article

Furans
Lewis Acids
Acetals
carbene
tetrahydrofuran