Maria Angeles Juanes Ortiz

Dr

Accepting PhD Students

20032020

Research output per year

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Personal profile

Academic Biography

Dr Maria Angeles Juanes Ortiz is a lecturer of Biomedical Sciences in the School of Health & Life Sciences at Teesside University. She has a broad expertise in cell and molecular biology, biochemistry, genetics, proteomics, and in particular in live-cell imaging. She has used several model systems such as single molecules in vitro, budding yeast and human cell lines. She has extensively published her work in the field of the cytoskeleton, cell division and polarity, cell adhesion and migration; presented in prestigious conferences, established collaborations worldwide, and mentored a number of undergraduate, postgraduate students and junior staff.

She studied Pharmacy, as a degree at Faculty of Pharmacy, University of Valencia in Spain. Then, she continued her PhD in the Biochemistry and Molecular Biology Department at Faculty of Biology, University of Valencia, under the supervision of Prof Bano and Dr Igual. Her PhD thesis focused on Cell cycle and cytoskeleton dynamics during polarized division and growth in budding yeast.

Following the completion of her PhD, Dr. Juanes embarked on several postdoctoral research positions, and stages as a visitor scientist in Europe, Asia and the USA. In 2008, she was awarded a ‘Ramon Areces fellowship’ and joined the group of Dr Segal at University of Cambridge, UK, where she investigated the formation and orientation of the mitotic spindle, inheritance and asymmetric fate of the centrosomes (yeast spindle pole bodies), and mechanisms that govern cortical capture of astral microtubules.

In 2010, she undertook her research in the group of Dr Piatti at the CRBM-CNRS in Montpellier, France. There she investigated the regulation of the phosphatase PP2A during budding yeast mitosis, and how several E3-ubiquitin ligases control cell polarity, cytokinesis and septin dynamics. She was awarded a ‘Fondation pour la Recherche Médicale (FRM) fellowship’ and ‘Merlion Fellowship from Institute Français’ to work as a visitor researcher in Dr Rancati lab, at the IMB A-Star in Singapore.

In 2015, she moved to Prof Goode's lab, at Brandeis University, USA. There, she furthered her expertise, from in vitro single-molecule TIRF assays to state-of-the-art imaging and functional studies in human cells. Inspired by her training as a yeast geneticist, she developed a strategic platform to explore the molecular basis for cytoskeletal crosstalk in cell adhesion and migration centered on the tumour suppressor Adenomatous Polyposis Coli (APC), gatekeeper of colorectal cancer and downregulator of the Wnt-β-catenin pathway. She discovered that APC nucleates actin filaments in cells, and coordinates actin and microtubules at focal adhesions to direct cell migration. M. Angeles has established strong collaborations with several French institutions such as the Centre de Recherche en Cancérologie - Institut Paoli Calmettes, and Institut Fresnel - Université Saint Jérôme in Marseille (France), where she worked as a visitor scientist in 2018.

Dr Juanes has joined the Teesside University as a Lecturer in Biomedical Science in February 2020. 

Summary of Research Interests

Dr Juanes' research interests are to understand the molecular mechanisms underlying cytoskeletal crosstalk during cell motility and cell division in the context of development with implications in diverse cancers. She investigates these questions across scales: from the most reductionist system using in vitro single molecule assays to most complex situations such as in human cell lines, tissues and organoids.

PhD and Research Opportunities

Students who are interested to join our research group are welcome to contact Maria Angeles (e-mail: m.juanes@tees.ac.uk). Postdoctoral fellows or research associate positions will be advertised according to the availability.

External Roles and Professional Activities

-Member of the British Society for Cell Biology, BSCB.

-Member of the Spanish Society or Biochemistry and Molecular Biology, SEBBM.

-Member of the American Society for Cell Biology, ASCB.

-Member of the International Mentoring Foundation for the Advancement of Higher Education (IMHAFE), and mentor of the Biomedicine Program.

-Member of the Journal of Life Science (JoLS) and Executive Editor Board.

Education/Academic qualification

PhD, University of Valencia

20022008

Master, University of Valencia

20012003

Bachelor, University of Valencia

19962001

External positions

Visitor Researcher, Aix-Marseille Université

Jan 2018Apr 2018

Visitor Researcher, Centre de Recherche en Cancérologie de Marseille, Institut National de la Santé et de la Recherche Médicale, Institut Paoli-Calmettes, Aix-Marseille Université, Centre National de la Recherche Scientifique, Marseille, France

Jan 2018Apr 2018

Executive Editor Board , Journal of Life Science

2016 → …

Senior postdoc, USA, Brandeis University

Jan 2015Jan 2020

Visitor Researcher, Singapore, IMB-A*Star

May 2013Jul 2013

Postdoc, France, CRBM-Montpellier, CNRS

Oct 2010Dec 2015

Postdoc, UK, University of Cambridge

Sep 2008Sep 2010

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Research Output

The microtubule plus tip protein EB1 inhibits APC-mediated actin nucleation

Juanes, M. A., Fees, C., Jaiswell, R. & Goode, BL., 2020, (Submitted) In : TBA.

Research output: Contribution to journalArticle

Novel Actin Regulatory Activities of the IQGAP-APC-Dia1 Complex Revealed by Single-Molecule Imaging

Hoeprich, G., Juanes, M. A. & Goode, B., 15 Feb 2019, In : Biophysical Journal. 116, 3 Supplement 1, p. 551a

Research output: Contribution to journalConference article

Open Access
  • The role of APC-mediated actin assembly in microtubule capture and focal adhesion turnover

    Juanes, M. A., Isnardon, D., Badache, A., Brasselet, S., Mavrakis, M. & Goode, B. L., 7 Oct 2019, In : Journal of Cell Biology. 218, 10, p. 3415-3435

    Research output: Contribution to journalArticle

    Open Access
    File
  • 24 Downloads (Pure)

    Recruitment of the mitotic exit network to yeast centrosomes couples septin displacement to actomyosin constriction

    Tamborrini, D., Juanes, M. A., Ibanes, S., Rancati, G. & Piatti, S., 17 Oct 2018, In : Nature Communications. 9, 1, 15 p., 4308.

    Research output: Contribution to journalArticle

    Open Access
    File
  • 17 Downloads (Pure)

    Adenomatous polyposis coli nucleates actin assembly to drive cell migration and microtubule-induced focal adhesion turnover

    Juanes, M. A., Bouguenina, H., Eskin, J. A., Jaiswal, R., Badache, A. & Goode, B. L., 4 Sep 2017, In : Journal of Cell Biology. 216, 9, p. 2859-2875

    Research output: Contribution to journalArticle

    Open Access