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Personal profile

Academic Biography

Dr Panagiota Filippou is a lecturer of Biomedical Sciences in the School of Health & Life Sciences at Teesside University.

Dr Filippou completed her postgraduate studies (MSc and PhD in Biochemistry) under the supervision of Prof. D.A Kyriakidis, at the Laboratory of Biochemistry, Department of Chemistry, Aristotle University of Thessaloniki, Greece. Her PhD thesis focused on the polyamine regulation and study of the AtoS/AtoC two-component signal transduction system.

Following the completion of her PhD in Biochemistry, Dr. Filippou undertook several postdoctoral research positions in Europe and in Canada. In 2010, she joined the Cyprus University of Technology (Cyprus) (Dr V. Fotopoulos’ group) as a postdoctoral researcher, where she focused on the elucidation of plant response under stress conditions and antioxidant mechanisms, using systems biology approaches. In 2013, she was awarded the prestigious EMBO-funded fellowship and joined the VIB-UGent Center (Prof D. Inzé group), Belgium, as a visiting researcher.

In 2014, Dr Filippou joined the group of Prof. Eleftherios Diamandis in the Advanced Center for Detection of Cancer, Department of Laboratory Medicine and Pathobiology, University of Toronto and the Department of Clinical Biochemistry, University Health Network, Toronto, Canada. Her main research interests focused on cancer biomarker discovery using mass spectrometry-based proteomics and other bioanalytical tools, the recombinant protein and monoclonal antibodies production for the development of highly sensitive and specific ELISA immunoassays and the enzyme inhibition studies for therapeutics.

As a lecturer at Teesside University (Sep-2018), Dr. Filippou is responsible of delivering and developing a multitude of modules that span main disciplines of human metabolism, clinical biochemistry and diagnostic techniques as well as establishing her current area of interest in cancer research at TU with internal and external collaborators. Currently, her research interests include the cancer biomarker discovery for early diagnosis and monitoring, identification of new bioactive molecules in cancer therapeutics and the host’s response to cancer therapy.

Dr Filippou has published in several highly-esteemed, peer-reviewed journals (h-index, 15; >1010 citations Google scholar; h-index, 14; >790 citations; Scopus, as of October 2019), and received several awards and scholarships of excellence. She is a member of the American Association for cancer research (AACR),  European Association of Cancer Research (EACR), the Metastasis Research Society (MRS), the Biochemical Society UK, the International Plant Proteomics Organization (INPPO) and the Hellenic Association of Biochemistry and Molecular Biology.

Summary of Research Interests

Nowadays, personalised medicine represents the future for individual diagnostics and cancer therapeutics. Consequently, there is an urgent need for further understanding the molecular basis of cancer and developing better diagnostics and therapeutic interventions. Dr Filippou`s laboratory focuses on the identification and elucidation of the role of proteins implicated in cancer progression and the tumor- and metastasis-promoting microenvironment, their clinical applications as diagnostic markers, predictors of prognosis and therapeutic response and the development of novel therapeutic targets.

Our translational research laboratory combines a variety of molecular, biochemical and analytical techniques along with established in vitro cell culture models (mammalian cancer cell lines) and patient`s specimens (tissues and biological fluids) to study relevant cancer-related pathways. We anticipate that our research will have future impact in cancer patient`s life and reinforce fruitful collaborations with the oncology scientific community. Briefly, our research interests include (but not limited to) the following areas:

1) Cancer biomarker discovery- Identification of novel proteins as cancer biomarkers in diagnostics and therapeutics.

We seek to identify novel proteins using proteomics and other analytical techniques (i.e mass spectrometry, ELISA immunoassays, IHC) that alone and/or in combination will serve as cancer biomarkers in diagnosis and therapeutic response.

2) Delineation of the biochemical pathways and mechanisms of carcinogenesis and metastatic progression, and deciphering the opportunities for therapeutic intervention.

We search to investigate the pathophysiological pathways involved in carcinogenesis and players in the metastatic cascade. Our ultimate goal is to identify novel therapeutic molecules (from natural products and newly synthesized organic compounds), which could act either alone, or in a synergistic way as therapeutic cancer agents.

 

PhD and Research Opportunities

Students who are interested to join our research group are welcome to contact Dr Filippou (e-mail: P.Philippou@tees.ac.uk).

PhD, Postdoctoral fellows or research associate positions will be advertised according to the availability.

Learning and Teaching Interests and Activities

Dr Filippou is currently the module leader of the following modules spanning the Clinical Biochemistry discipline:

1)  "Human Μetabolism and Clinical Biochemistry"(FPL2023-N-CF1) 

2)  "Clinical Biochemistry" (PCI3031-N) 

She is also a module tutor in several other modules including the "Human Ageing and Disease", "General Chemistry and Biochemistry", "Medical Laboratory Science", "Biochemistry and Chemical Science" (Intensive Block Delivery), "Clinical Pharmacology", "Clinical Correlations of Food and Nutrition".

External Roles and Professional Activities

Professional Bodies

  • The American Association for Cancer Research (AACR)
  • The European Association for Cancer Research (EACR)
  • The Biochemical Society, UK
  • The Metastasis Research Society (MRS)
  • Fellow-Institute of Biomedical Science (FIBMS)
  • International Plant Proteomics Organization (INPPO)
  • Hellenic Association of Biochemistry and Molecular Biology
  • Hellenic Union of Chemists

Education/Academic qualification

PhD, Aristotle University of Thessaloniki

Master, Aristotle University of Thessaloniki

Bachelor, Aristotle University of Thessaloniki

External positions

Associate Topic Editor for Molecular and Cellular Oncology-Frontiers in Oncology

3 Jul 2019 → …

Fingerprint Dive into the research topics where Panagiota Filippou Philippou is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

Kallikreins Medicine & Life Sciences
Medicago truncatula Agriculture & Biology
Nitroprusside Medicine & Life Sciences
nitric oxide Agriculture & Biology
Tissue Kallikreins Medicine & Life Sciences
abiotic stress Agriculture & Biology
Polyamines Medicine & Life Sciences
Escherichia coli Chemical Compounds

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output 2007 2019

Midkine (MDK) growth factor: a key player in cancer progression and a promising therapeutic target

Filippou, P. S., Karagiannis, G. & Constantinidou, A., 4 Dec 2019, In : Oncogene.

Research output: Contribution to journalArticle

Intercellular Signaling Peptides and Proteins
Neoplasms
Tumor Biomarkers
Therapeutics
Precision Medicine

Screening of chemical libraries in pursuit of kallikrein-5 specific inhibitors for the treatment of inflammatory dermatoses

Di Paolo, C. T., Filippou, P. S., Yu, Y., Poda, G., Diamandis, E. P. & Prassas, I., 27 May 2019, In : Clinical Chemistry and Laboratory Medicine.

Research output: Contribution to journalArticle

Small Molecule Libraries
Kallikreins
Skin Diseases
Screening
Skin

Biochemical characterization of human tissue kallikrein 15 and examination of its potential role in cancer

Filippou, P. S., Ren, A. H., Bala, S., Papaioannou, M. D., Brinc, D., Prassas, I., Karakosta, T. & Diamandis, E. P., 18 Jun 2018, In : Clinical Biochemistry. 58, p. 108-115 8 p.

Research output: Contribution to journalArticle

Tissue Kallikreins
Kallikreins
Neoplasms
Trypsin
Prostatic Neoplasms

Exploring the potential of mucin 13 (MUC13) as a biomarker for carcinomas and other diseases

Filippou, P. S., Ren, A. H., Korbakis, D., Dimitrakopoulos, L., Soosaipillai, A., Barak, V., Frenkel, S., Pe'Er, J., Lotem, M., Merims, S., Molina, R., Blasutig, I., Bogdanos, D. P. & Diamandis, E. P., 25 Oct 2018, In : Clinical Chemistry and Laboratory Medicine. 56, 11, p. 1945-1953 9 p.

Research output: Contribution to journalArticle

Biomarkers
Mucins
Carcinoma
Serum
Cells

Expression profile of human tissue kallikrein 15 provides preliminary insights into its roles in the prostate and testis

Filippou, P. S., Ren, A. H., Soosaipillai, A., Papaioannou, M. D., Korbakis, D., Safar, R., Diamandis, E. P. & Conner, J. R., 1 Sep 2018, In : Clinical Biochemistry. 59, p. 78-85 8 p.

Research output: Contribution to journalArticle

Tissue Kallikreins
Kallikreins
Testis
Prostate
Cells