Projects per year
Personal profile
Academic Biography
Muhammad Safwan Akram is working at National Horizons Centre and School of Health and Life Sciences as a Professor of Biomanufacturing, Engineering Biology and Innovation in Biosciences. He has previously worked as Associate Professor of Biological & Process Engineering in SHLS. Prior to that he has worked as an Assistant Professor at University of the Punjab, Lahore, Pakistan. Safwan obtained his PhD in Analytical Biotechnology from the Department of Chemical Engineering and Biotechnology, University of Cambridge where he also did his post-doc developing low cost diagnostics. Prior to that he completed his M.Phil in Bioscience Enterprise under the auspices of Cambridge/MIT Partnership. His work has been published in reputed journals like Nature Biotechnology, Lab on a Chip & Annual Reviews of Analytical Chemistry. He has been awarded Medimmune Award and CambridgeSens Innovative Idea award for research excellence. He provides consultancy to venture capital funds, biotech and pharma companies. During his academic career, he has taught courses on Protein design and engineering, Recombinant DNA Technology and Stem Cells, Biosensors, Technology Enterprise and Pharmaceutical Biotechnology. Safwan was voted by the students to win university wide Star award for most outstanding teaching.
Summary of Research Interests
- Biomanufacturing of nanobodies, monoclonal antibodies and AAV for gene therapy applications
- Synthetic biology of valuable compounds
- Low cost diagnostics for various biotechnology applications
- Biomimetics for sensors and fermentation applications
- Bioactive scaffolds for Tissue Engineering
- Exploring relationship between Inclusion Bodies (IBs) and cell viability through genomic and proteomic tools
- Paper based diagnostics to determine drug quality
- Polymorphism in amyloid proteins
- Start up valuations of Biotech businesses
Safwan’s lab is looking for PhD students for the above-mentioned projects. If interested e-mail him directly.
Safwan’s laboratory has won substantial funding over the last 9 years that includes
As Principal Investigator
- Defence & Security Accelerator Award, in collaboration with Selective Antibodies & Smith LLP. (£300,000) (2025)
- BBSRC Landscape Award, Yorkshire Biosciences Doctoral Training Programme (YBDTP) University lead (10 PhD studentships for Teesside University) (£1,500,000)(2024 – 2030)
- BBSRC Landscape Award, North East England Doctoral Landcsape Awards (NEEDL) University lead (10 PhD studentships for Teesside University) (£1,500,000)(2024 – 2030)
- Launchpad NetZero CR&D grant in collaboration with Hexis Labs (£497,000) (2023 – 2025)
- Accelerated Knowledge Transfer to Innovate (AKT2I) with Hart Biologicals Pvt. Ltd.(£30,479) (2022-2023)
- Two direct studentships from Fujifilm Diosynth Biotechnologies, Centre from Process Innovation and Hart Biologicals (£160,000) (2023-2027)
- One studentship from IBIOIC (BBSRC CTP programme)with Hexis Labs (£140,000) (2021-2024)
- Advance Biologics Manufacturing Training – for a leading biopharma manufacturer of the value (£260,000) (2020-2021)
- Inclusion Bodies for Industrial Biotechnology – (£100,000) from Research England’s Funding through THYME as a leading PI, in collaboration with FDB and University of York, (£20,000) additional funding from FDB (2019-2022)
- ERDF PhD studentship in collaboration with Hart Innovations (£117,000) (2018-2023)
- Innovate UK grant for (£130,000) as a PI for “Downstream processing of monoclonal antibodies” in collaboration with GlycoSelect UK Ltd (2017-2018)
- Won a Graduate Tutorship i.e. Phd studentship (fees + salary) ~ £85,000 (2017)
- Won two research grants for consumables from Teesside University’s Research Fund amounting £6,000 (2015)
- CambridgeSens Award of £5000 for creating a novel biological solar cell (2009)
As Co-Investigator
- RESILIENCE: Medicines Manufacturing Skills Centre of Excellence (£4,200,000) (2024) Co-I with Prof. Vikki Rand, Prof. Gary Montague & Mr. Connor Foster
- One studentship from IBIOIC (BBSRC CTP programme) with FDBK and University of York (£140,000) (2021-2024)
- Advanced Therapies Skills Training Network (ATSTN) Grant as co-PI with Prof. Gary Montague and Dr. Jen Vanderhoven (£1,000,000) (2021-2022)
- Virtual Center of Advance Therapies Skills Programme (vCATTS) – Development of bioprocessing videos for hands on training (£60,000) as lead for the chromatography strand (2020-2021)
- Innovate UK grant as a co-applicant for (£180,000) in collaboration with Quorn foods. (2018)
- Won an internal collaborative bid for equipment amounting £57,000 to buy NMR (2015)
Enterprise Interest and Activities
Prof. Dr. M. Safwan Akram has been involved with a start-up “YourBug” and a pharma company named “Renacon Pharma”. He is always on a look out for projects worth commercialising and making a difference to society. He sits on the scientific advisory board of Hexis Laboratories, UK and GlycoSelect Ltd., Ireland.
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Collaborations and top research areas from the last five years
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Sustainable low carbon cell-based platform for scale-up production of high-valued materials for personal care and biopharmaceuticals
Akram, S. (PI)
1/04/23 → 31/03/25
Project: Research
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Platform Cell Factory for the production of lipopolypeptides for cosmetic industry
Akram, S. (PI), Mosely, J. (CoI) & Gao, H. (CoI)
UKRI BBSRC - Industrial Biotech Innovation Centre (IBioIC)
1/12/21 → 30/11/25
Project: Research
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Investigating the Control and Molecular Architecture of Inclusion Body Formation
Butler, L. (RA), Bray, G. (RA) & Akram, S. (PI)
6/09/19 → …
Project: Research
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Creating a novel cell factory for glycopeptide antibiotic production
Akram, S. (PI)
1/12/22 → 30/04/23
Project: Research
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KTP - Development of a dashboard for Quorn proteome
Taylor, G. (PI), Scrivens, J. (PI), Montague, G. (PI) & Akram, S. (PI)
1/02/20 → 28/02/22
Project: Research
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Paper-based microfluidic point-of-care diagnostic devices
Yetisen, A. K., Akram, M. S. & Lowe, C. R., 21 Jun 2013, In: Lab on a Chip. 13, 12, p. 2210-2251 42 p.Research output: Contribution to journal › Review article › peer-review
856 Citations (Scopus) -
Consanguineous marriages increase the incidence of recurrent tuberculosis: Evidence from whole exome sequencing
Akbar, N. U., Ahmad, S., Khan, T. A., Tayyeb, M., Akhter, N., Shafiq, L., Khan, S. N., Alam, M. M., Abdullah, A. M., Rehman, M. F. U., Bajaber, M. A. & Akram, M. S., 1 Mar 2024, In: Infection, Genetics and Evolution. 118, 105559.Research output: Contribution to journal › Article › peer-review
Open Access -
Water pollution remediation: Synthesis and characterization of poly(o-methylaniline)/ZnO/rGO composite for photocatalytic degradation of dyes
Ahmad, M. N., Anjum, M. N., Farid, M. F., Haq, A.-U., Ali, A., ur Rehman, M. F., Assiri, M. A. & Akram, S., 18 Jan 2024, In: Polymers for Advanced Technologies. 35, 1, 12 p., e6269.Research output: Contribution to journal › Article › peer-review
Open Access -
Chemical Characterization, Antioxidant, Antimicrobial, Cytotoxicity and In-silico Studies of n-hexane Extract and Essential Oils from Citrus limon Leaves
Riaz, M., Qadir, R., Akhtar, M. T., Misbah Ur Rehman, M., Anwar, F., Eman, R., ur Rehman, M. F. & Akram, S., 20 Jan 2023, In: Chemistry and Biodiversity. 20, 1, 12 p., e202200537.Research output: Contribution to journal › Article › peer-review
Open AccessFile113 Downloads (Pure) -
Designing strategies towards non-fullerene DTCR1 based compounds for the exploration of non-linear optical behavior
Khalid, M., Saeed, Z., Shafiq, I., Asghar, M. A., Braga, A. A. C., Al-Shehri, S. M., Akram, S. & Chandra Ojha, S., 7 Jul 2023, In: Journal of Saudi Chemical Society. 27, 16 p., 101683.Research output: Contribution to journal › Article › peer-review
Open AccessFile52 Downloads (Pure)
Datasets
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Structural modulation of π-conjugated linkers in D-π-A dyes based on Triphenylamine dicyanovinylene framework to explore the NLO properties
Akram, M. S. (Contributor), Unknown Publisher, 1 Jul 2021
DOI: 10.5061/dryad.4tmpg4f99, https://zenodo.org/records/5056980
Dataset
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Supplementary material from "Structural modulation of π-conjugated linkers in D–π–A dyes based on triphenylamine dicyanovinylene framework to explore the NLO properties"
Khalid, M. (Creator), Khan, M. U. (Creator), Shafiq, I. (Creator), Hussain, R. (Creator), Ali, A. (Creator), Imran, M. (Creator), Braga, A. A. C. (Creator), Fayyaz Ur Rehman, M. (Contributor) & Akram, M. S. (Creator), figshare, 2021
DOI: 10.6084/m9.figshare.c.5527182.v1, https://rs.figshare.com/collections/Supplementary_material_from_Structural_modulation_of_-conjugated_linkers_in_D_A_dyes_based_on_triphenylamine_dicyanovinylene_framework_to_explore_the_NLO_properties_/5527182/1
Dataset
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Supplementary Information from Structural modulation of π-conjugated linkers in D–π–A dyes based on triphenylamine dicyanovinylene framework to explore the NLO properties
Khalid, M. (Creator), Khan, M. U. (Creator), Shafiq, I. (Creator), Hussain, R. (Creator), Ali, A. (Creator), Imran, M. (Creator), Braga, A. A. C. (Creator), Fayyaz Ur Rehman, M. (Contributor) & Akram, M. S. (Creator), figshare, 2021
DOI: 10.6084/m9.figshare.15048708.v1, https://doi.org/10.6084%2Fm9.figshare.15048708.v1
Dataset
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Supplementary material from "Structural modulation of π-conjugated linkers in D–π–A dyes based on triphenylamine dicyanovinylene framework to explore the NLO properties"
Khalid, M. (Creator), Khan, M. U. (Creator), Shafiq, I. (Creator), Hussain, R. (Creator), Ali, A. (Creator), Imran, M. (Creator), Braga, A. A. C. (Creator), Fayyaz Ur Rehman, M. (Contributor) & Akram, M. S. (Creator), The Royal Society, 2021
DOI: 10.6084/m9.figshare.c.5527182, https://rs.figshare.com/collections/Supplementary_material_from_Structural_modulation_of_-conjugated_linkers_in_D_A_dyes_based_on_triphenylamine_dicyanovinylene_framework_to_explore_the_NLO_properties_/5527182
Dataset
Press/Media
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Huge grant for Newcastle firm helping to make safer cosmetics and drugs
19/05/23
1 item of Media coverage
Press/Media: Press / Media
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HexisLab secure six-figure funding to deliver innovation project
21/05/23
1 item of Media coverage
Press/Media: Press / Media
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Future vaccine makers to get VR-assisted training centre of excellence
Rand, V., Akram, M. S. & Gaskell, C.
14/03/24
1 item of Media coverage
Press/Media: Press / Media