Projects per year
Personal profile
Academic Biography
Dr. Shweta Kuba is a dynamic and accomplished professional in the field of Bioinformatics, making significant contributions to both academia and research. Her journey in the academic realm began in 2022 when she assumed the role of Lecturer of Bioinformatics at the School of Health and Life Sciences at Teesside University.
Dr. Kuba's academic prowess was cultivated during her postgraduate studies in Bioinformatics, where she earned both a Master's and a Ph.D. in her home country, India. It was during her doctoral research that she received recognition on an international scale with the prestigious Israel Government Fellowship, allowing her to be a part of ground-breaking research at the Agricultural Research Organization (A.R.O) in Israel.
Demonstrating her commitment to addressing real-world challenges, Dr. Kuba secured a Science and Engineering Research Board-National Post Doctoral Fellowship (SERB-NPDF) from the Department of Science and Technology, India. This grant was dedicated to developing resistance against Leaf curl viruses in tomato plants, showcasing her dedication to advancing agricultural science.
In 2020, Dr. Kuba embarked on a new phase of her research career by delving into the exploration of genetic mutation-specific potential drug targets. This endeavour was made possible by a prestigious grant from the Medical Research Council, positioning her at the Faculty of Biology, Medicine and Health at the University of Manchester, United Kingdom. Her work in this domain holds promise for revolutionizing therapeutic interventions.
Continuing her trajectory of impactful research, Dr. Kuba, in 2021, transitioned to the Institute of Life Course and Medical Sciences at the University of Liverpool, United Kingdom. Here, her focus shifted to musculoskeletal and ageing science, driven by the support of the esteemed Dunhill Medical Grant. This grant not only underscores the significance of her research but also highlights her dedication to addressing critical issues related to health and ageing.
Dr. Shweta Kuba's journey reflects a passion for advancing knowledge in Bioinformatics and a commitment to applying her expertise to address global challenges. Her multifaceted contributions, spanning various continents and encompassing diverse research areas, establish her as a prominent figure in the field of life sciences.
Summary of Research Interests
Dr. Shweta Kuba's research interests encapsulate a diverse and cutting-edge array of topics at the intersection of bioinformatics, genetics, and developmental biology. Her current focus involves the following key areas:
Genetic Disease Modeling with Pluripotent Stem Cells for Drug Target Discovery:
Dr. Kuba is deeply engaged in leveraging pluripotent stem cells to model genetic diseases. This innovative approach allows her to recreate the complex genetic landscape of diseases, providing a powerful platform for understanding disease mechanisms and identifying potential drug targets. By employing pluripotent stem cells, her research aims to bridge the gap between genetic variations and the development of targeted therapeutic interventions.
Musculoskeletal Diseases & Developmental Disorders:
Within the realm of musculoskeletal diseases and developmental disorders, Dr. Kuba explores the intricate molecular mechanisms underlying these conditions. Her research delves into understanding the genetic and epigenetic factors contributing to musculoskeletal diseases and developmental disorders. This comprehensive approach aims to uncover novel insights into disease aetiology, progression, and potential avenues for intervention.
Spatio-Temporal Regulation of RNA-Binding Proteins in Developmental Disorders:
Dr. Kuba is actively investigating the spatio-temporal regulation of RNA-binding proteins, particularly in the context of developmental disorders. By elucidating the dynamic interactions and regulatory networks involving RNA-binding proteins, her research aims to unveil the molecular intricacies that contribute to abnormal developmental processes. This line of inquiry holds promise for identifying key players in developmental disorders and uncovering potential therapeutic targets.
Association of Altered Patterns of mRNA Decay with Ageing:
Another facet of Dr. Kuba's research endeavours focuses on understanding the association between altered patterns of mRNA decay and the ageing process. Investigating how mRNA decay patterns change with age is crucial for unravelling the molecular mechanisms that underlie age-related changes in cellular function. This research could have broad implications for our understanding of the ageing process and may contribute to the development of interventions to promote healthy ageing.
Academic Responsibilities
Module Leader:
Proteomic Technologies(SCI4076-N-FJ1-2023)
Genomic Technologies(SCI4075-N-BF1-2023)
Module Instructor:
Programming Skills (SCI4017-N-CF1)
Data Analytics (SCI4019-N-CF1)
Big Data (SCI0002-N-GJ1)
Advanced Bioinformatics (SCI4016-N-GJ1)
Life Science Project (SCI4013-N-BF1)
Science Research Project (SCI3051-N-BJ1)
Advanced/Applied Practice in Health & Life Sciences (SCI4039-N-BF1)
Education/Academic qualification
PhD, Bioinformatics
Award Date: 19 Jan 2016
Master, Bioinformatics
Award Date: 7 Mar 2009
External positions
Honorary Lecturer, University of Liverpool
1 Apr 2022 → …
Post Doctoral Research Associate, University of Liverpool
1 Sept 2021 → 28 Feb 2022
Bioinformatician, University of Manchester
2 Jan 2020 → 30 Jun 2021
Fingerprint
- 1 Similar Profiles
Collaborations and top research areas from the last five years
Projects
- 2 Finished
-
Investigation into the change of microbiome of cooked rice through traditional soaking process
Kuba, S. (CoI)
1/06/23 → 30/09/23
Project: Research
-
BRECON: Building REsearch Capacity on Oral cancer genomics and bioinformatics in sub-SaharaN Africa Project
Nnyanzi, L. (PI), Adisa, A. (CoI), Aladelusi, T. (CoI), Kuba, S. (CoI), Lenis, V. P. (CoI), Kanmodi, K. (CoI), Sarker, M. (CoI), Nkhata, M. (CoI), Adetunji, C. (CoI), Amzat, J. (CoI), Kunonga, E. (CoI) & Ogbureke, K. (CoI)
2/01/23 → 31/07/23
Project: Research
-
Human pluripotent stem cell-derived kidney organoids reveal tubular epithelial pathobiology of heterozygous HNF1B-associated dysplastic kidney malformations
Bantounas, I., Rooney, K. M., Lopes, F. M., Tengku, F., Woods, S., Zeef, L. A. H., Lin, I.-H., Kuba, S. Y., Bates, N., Hummelgaard, S., Hillman, K. A., Cereghini, S., Woolf, A. S. & Kimber, S., 23 May 2024, In: Stem Cell Reports. 19, 6, p. 859-876Research output: Contribution to journal › Article › peer-review
Open Access -
Analysis of RNA polyadenylation in healthy and osteoarthritic human articular cartilage
Winstanley-Zarach, P., Rot, G., Kuba, S., Smagul, A., Peffers, M. J. & Tew, S. R., 1 Apr 2023, In: International Journal of Molecular Sciences. 24, 7, 18 p., 6611.Research output: Contribution to journal › Article › peer-review
Open AccessFile148 Downloads (Pure) -
Human pluripotent stem cell-derived kidney organoids reveal tubular epithelial pathobiology of heterozygousHNF1B-associated dysplastic kidney malformations
Bantounas, I., Rooney, K. M., Lopes, F. M., Tengku, F., Woods, S., Zeef, L. A. H., Kuba, S. Y., Bates, N., Hummelgaard, S., Hillman, K. A., Cereghini, S., Woolf, A. S. & Kimber, S. J., 15 Mar 2023, (Submitted) In: bioRxiv.Research output: Contribution to journal › Article
-
Status of Omics Research Capacity on Oral Cancer in Africa: A Systematic Scoping Review Protocol
Nnyanzi, L. A., Adisa, A. O., Kanmodi, K. K., Aladelusi, T. O., Salami, A. A., Amzat, J., Angione, C., Nwafor, J. N., Uwambaye, P., Okee, M., Kuba, S. Y., Mujuni, B., Ibingira, C., Ogbureke, K. U. E. & Jayasinghe, R. D., 6 Apr 2023, In: BioMedInformatics. 3, 2, p. 327-338 12 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Regulation of tgfβ signalling by trpv4 in chondrocytes
Woods, S., Humphreys, P. A., Bates, N., Richardson, S. A., Kuba, S. Y., Brooks, I. R., Cain, S. A. & Kimber, S. J., 24 Mar 2021, In: Cells. 10, 4, 19 p., 726.Research output: Contribution to journal › Article › peer-review
Open Access3 Citations (Scopus)