Personal profile
Academic Biography
Dr Takanori Furukawa is a Vice-Chancellor’s Research Fellow who joined the School of Health & Life Sciences at Teesside University in November 2023. He is a fungal molecular biologist with more than 15 years of research experience in medical mycology and fungal biotechnology. His current research primarily focuses on saving lives from human fungal diseases by understanding the molecular basis of pathogenicity and antifungal drug resistance using the major mould pathogen of human lungs, Aspergillus fumigatus, as a model system.
Takanori completed his PhD in Bioengineering in 2009 at Nagaoka University of Technology in Japan, where he studied the transcriptional regulation of lignocellulose-degrading enzymes in the model cellulolytic fungus Trichoderma reesei and genetic engineering of the fungus for bioconversion of lignocellulosic biomass, the most abundant renewable feedstock on Earth. After a postdoctoral position at Nagaoka University of Technology, he moved from Japan to the UK in 2013 to join the Centre for Synthetic and Systems Biology (SynthSys) at the University of Edinburgh as a postdoctoral research associate. Working closely with an industrial partner, Takanori constructed an artificial lignin-degrading enzyme system using yeasts as chassis microorganisms with synthetic biology approaches and investigated their potential for the bioconversion of lignin, the major aromatic biopolymer derived from lignocellulosic biomass.
In 2015, Takanori joined the Manchester Fungal Infection Group (MFIG) to pursue further career growth in the field of medical mycology. His main achievement at the MFIG includes the characterisation of a whole-transcription factor knockout mutant collection of the important human fungal pathogen A. fumigatus, which led to the identification of the full-cohort of transcription factors that govern resistance to clinically important antifungals. In 2022, he was awarded a University of Manchester/Wellcome-ISSF "EDI Perera Fellowship”, which allowed him to develop an independent research trajectory focusing on epigenetics in medical mycology.
In his Vice-Chancellor’s Research Fellowship at Teesside University, Takanori will investigate the role of epigenetics in fungal infection biology using A. fumigatus as a model system.
Summary of Research Interests
Takanori’s research interests lie in understanding the molecular mechanisms of gene regulation in eukaryotic microorganisms, especially in filamentous fungi, and their application in medical mycology and fungal biotechnology. He is also interested in understanding various life processes using filamentous fungus as a model system.
His current research interests include
- Epigenetics in infection biology
- Molecular basis of fungal pathogenecity
- Antifungal drug resistance
- Fungal white biotechnology
Research Projects & External Funding
2025 The Academy of Medical Sciences Springboard Award "Deciphering the Epigenetic Gene Regulatory Landscape in the Major Mould Pathogen of Humasn Lungs" (PI)
2025 The Royal Society Research Grant "Exploring the Role of mRNA Epigenetics in a Human Fungal Pathogen" (PI)
2024 British Society for Medical Mycology Travel Grant (PI)
2024 British Mycological Society Research Grant "Investigating the Role of Epigenetic Mechanisms in Antifungal Adaptive Responses" (PI)
2022 Fungal Infection Trust Research Grant "Elucidating the Epigenetic Landscape of the Human Fungal Pathogen Aspergillus fumigatus" (PI)
2022 University of Manchester/Wellcome ISSF EDI Perera Fellowship (PI)
External Roles and Professional Activities
2019 - present The British Society for Medical Mycology (member)
2015 - present The British Mycolgical Society (member)
Education/Academic qualification
PhD, Doctor of Engineering, Nagaoka University of Technology
1 Apr 2006 → 30 Jun 2009
Award Date: 30 Jun 2009
Master, Master of Engineering, Nagaoka University of Technology
1 Apr 2004 → 31 Mar 2006
Award Date: 31 Mar 2006
Bachelor, Bachelor of Engineering, Nagaoka University of Technology
1 Apr 2002 → 31 Mar 2004
Award Date: 31 Mar 2004
Associate in Engineering, National Institute of Technology, Oyama College
1 Apr 1997 → 31 Mar 2002
Award Date: 31 Mar 2002
External positions
Honorary Research Fellow, University of Manchester
1 Aug 2024 → …
Guest Lecturer (BSc Bioengineering), Nagaoka University of Technology
1 Nov 2018 → …
Fingerprint
- 1 Similar Profiles
Collaborations and top research areas from the last five years
-
Deciphering the Epigenetic Gene Regulatory Landscape in the Major Mould Pathogen of Human Lungs
Furukawa, T. (PI)
1/05/25 → 30/04/27
Project: Research
-
Exploring the Role of mRNA Epigenetics in a Human Fungal Pathogen
Furukawa, T. (PI)
1/03/25 → 28/02/26
Project: Research
-
Investigating the Role of Epigenetic Mechanisms in Antifungal Adaptive Responses
Furukawa, T. (PI)
1/08/24 → 31/12/25
Project: Research
-
Aspergillus fumigatus Can Display Persistence to the Fungicidal Drug Voriconazole
Scott, J., Valero, C., Mato-López, Á., Donaldson, I. J., Roldán, A., Chown, H., Rhijn, N. V., Lobo-Vega, R., Gago, S., Furukawa, T., Morogovsky, A., Ami, R. B., Bowyer, P., Osherov, N., Fontaine, T., Goldman, G. H., Mellado, E., Bromley, M. & Amich, J., 13 Mar 2023, In: Microbiology spectrum. 11, 2Research output: Contribution to journal › Article › peer-review
Open AccessFile98 Downloads (Pure) -
Exploring a novel genomic safe-haven site in the human pathogenic mould Aspergillus fumigatus
Furukawa, T., van Rhijn, N., Chown, H., Rhodes, J., Alfuraiji, N., Fortune-Grant, R., Bignell, E., Fisher, M. C. & Bromley, M., 1 Jul 2022, In: Fungal Genetics and Biology. 161, 103702.Research output: Contribution to journal › Article › peer-review
-
The negative cofactor 2 complex is a key regulator of drug resistance in Aspergillus fumigatus
Furukawa, T., van Rhijn, N., Fraczek, M., Gsaller, F., Davies, E., Carr, P., Gago, S., Fortune-Grant, R., Rahman, S., Gilsenan, J. M., Houlder, E., Kowalski, C. H., Raj, S., Paul, S., Cook, P., Parker, J. E., Kelly, S., Cramer, R. A., Latgé, J. P. & Moye-Rowley, S. & 3 others, , 1 Dec 2020, In: Nature Communications. 11, 1, 427.Research output: Contribution to journal › Article › peer-review
Open Access -
The fungal CCAAT-binding complex and HapX display highly variable but evolutionary conserved synergetic promoter-specific DNA recognition
Furukawa, T., Scheven, M. T., Misslinger, M., Zhao, C., Hoefgen, S., Gsaller, F., Lau, J., Jöchl, C., Donaldson, I., Valiante, V., Brakhage, A. A., Bromley, M. J., Haas, H. & Hortschansky, P., 22 Feb 2020, In: Nucleic Acids Research. 48, 7, p. 3567-3590 24 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Deciphering the molecular mechanisms behind cellulase production in trichoderma reesei, the hyper-cellulolytic filamentous fungus
Shida, Y., Furukawa, T. & Ogasawara, W., 1 Sept 2016, In: Bioscience, Biotechnology and Biochemistry. 80, 9, p. 1712-1729 18 p.Research output: Contribution to journal › Article › peer-review
Open Access