Targeting Circadian Clock Dysfunction in Alzheimer's Disease

Many biological processes, including sleep, hormone release and eating habits, follow a circadian rhythm, a 24-hour cycle that is part of our internal clock. Disruption of circadian rhythms has been linked to diseases such as Alzheimer’s disease (AD). Many genes responsible for the circadian clock are aberrantly expressed in AD, rendering it a putative drug target. The TClock4AD project, funded by the Marie Skłodowska-Curie Actions programme, aims to develop novel drugs that target the circadian clock. Researchers will investigate the molecular mechanisms that govern circadian rhythms in AD, identify therapeutic targets and develop rationally designed compounds, which will be tested for their efficacy in innovative screening models.