α1-adrenoreceptor activity does not explain lower morning endothelial-dependent, flow-mediated dilation in humans

Helen Jones, Nia C S Lewis, Daniel J. Green, Philip N. Ainslie, Samuel J E Lucas, Yu Chieh Tzeng, Emily J M Grant, Greg Atkinson

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    13 Citations (Scopus)

    Abstract

    Early morning reduction in endothelium-dependent, flow-mediated dilation (FMD) may contribute to the high incidence of sudden cardiac death at this time of day. The mechanisms underpinning diurnal variation in FMD are unclear, but potentially relate to a circadian rhythm in sympathetic nerve activity. We hypothesized that blockade of a1-mediated sympathetic nerve activity would act to attenuate the diurnal variation in FMD. In a randomized and placebo-controlled design, we measured brachial artery FMD in 12 participants (mean age = 26 yr, SD = 3) at 0600 and 1600 after ingestion of an a 1 -blocker (prazosin, 1 mg/20 kg body mass) or placebo. Arterial diameter and shear rate were assessed using edge-detection software. Heart rate and blood pressure were also measured. Data were analyzed using linear mixed modeling. Following placebo, FMD was 8 ± 2% in the morning compared with 10 ± 3% in the afternoon (P = 0.04). Blockade with prazosin led to a slight but nonsignificant increase in morning FMD (P = 0.24) and a significant (P = 0.04) decrease in afternoon FMD, resulting in no diurnal variation (P = 0.20). Shear rate did not differ in the morning or afternoon under either condition (P > 0.23). Blood pressure was lower following prazosin compared with placebo (P < 0.02), an effect that was similar at both times of day (P > 0.34). Heart rate and norepinephrine levels were higher in the afternoon following prazosin. These data indicate that a1-adrenoreceptor activity does not explain lower morning endothelium-dependent FMD.

    Original languageEnglish
    Pages (from-to)1437-1442
    Number of pages6
    JournalAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
    Volume300
    Issue number6
    DOIs
    Publication statusPublished - 1 Jun 2011

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