3D hierarchically porous magnetic molybdenum trioxide@gold nanospheres as a nanogap-enhanced Raman scattering biosensor for SARS-CoV-2

Ojodomo J. Achadu, Njemuwa Nwaji, Dongkyu Lee, Jaebeom Lee, Eser M. Akinoglu, Michael Giersig, Enoch Y. Park

Research output: Contribution to journalArticlepeer-review

3 Downloads (Pure)

Abstract

The global pandemic of COVID-19 is an example of how quickly a disease-causing virus can take root and threaten our civilization. Nowadays, ultrasensitive and rapid detection of contagious pathogens is in high demand. Here, we present a novel hierarchically porous 3-dimensional magnetic molybdenum trioxide-polydopamine-gold functionalized nanosphere (3D mag-MoO3-PDA@Au NS) composed of plasmonic, semiconductor, and magnetic nanoparticles as a multifunctional nanosculptured hybrid. Based on the synthesized 3D mag-MoO3-PDA@Au NS, a universal "plug and play"biosensor for pathogens is proposed. Specifically, a magnetically-induced nanogap-enhanced Raman scattering (MINERS) detection platform was developed using the 3D nanostructure. Through a magnetic actuation process, the MINERS system overcomes Raman signal stability and reproducibility challenges for the ultrasensitive detection of SARS-CoV-2 spike protein over a wide dynamic range up to a detection limit of 10-15 g mL-1. The proposed MINERS platform will facilitate the broader use of Raman spectroscopy as a powerful analytical detection tool in diverse fields.

Original languageEnglish
Pages (from-to)871-883
Number of pages13
JournalNanoscale Advances
Volume4
Issue number3
DOIs
Publication statusPublished - 4 Jan 2022

Bibliographical note

Funding Information:
O. J. A. sincerely thanks the Japan Society for the Promotion of Science (JSPS) for a postdoctoral fellowship (Grant No. P19348). This work was partly supported by the Japan Agency for Medical Research and Development (20hm0102080h0001). Funding by the Guangdong Innovative Entrepreneurial Team Program (no. 2016ZT06C517) and the Science and Technology Program of Guangdong (no. 2021A0505030014) is gratefully acknowledged.

Publisher Copyright:
© 2022 The Royal Society of Chemistry.

Fingerprint

Dive into the research topics of '3D hierarchically porous magnetic molybdenum trioxide@gold nanospheres as a nanogap-enhanced Raman scattering biosensor for SARS-CoV-2'. Together they form a unique fingerprint.

Cite this