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2019
111 Downloads (Pure)

A new family of cell surface located purine transporters in Microsporidia and related fungal endoparasites

Major, P., Sendra, K. M., Dean, P., Williams, T. A., Watson, A. K., Thwaites, D. T., Embley, T. M. & Hirt, R. P., 29 Jul 2019, In : eLife. 8

Research output: Contribution to journalArticle

Open Access
File
Microsporidia
Parasites
Genes
Genome
Membrane Transport Proteins

Regulation of phagosome functions by post-translational modifications: a new paradigm

Dean, P., Heunis, T., Härtlova, A. & Trost, M., 1 Feb 2019, In : Current Opinion in Chemical Biology. 48, p. 73-80 8 p.

Research output: Contribution to journalArticle

Open Access
phagosomes
post-translational modification
organelles
antigen presentation
latex

Stealing is the Deal: Parasites that grow within animal cells use a family of transport proteins to take nucleotides, the building blocks of DNA, from their hosts.

Major, P., Sendra, K., Dean, P., Williams, T. A., Watson, A. K., Thwaites, D. T., Embley, T. M. & Hirt, R. P., 19 Aug 2019, In : eLife.

Research output: Contribution to journalComment/debate

Open Access
Theft
Carrier Proteins
Parasites
Animals
Nucleotides
2018
84 Downloads (Pure)

Transporter gene acquisition and innovation in the evolution of Microsporidia intracellular parasites

Dean, P., Sendra, K. M., Williams, T. A., Watson, A. K., Major, P., Nakjang, S., Kozhevnikova, E., Goldberg, A. V., Kunji, E. R. S., Hirt, R. P. & Embley, T. M., 27 Apr 2018, In : Nature Communications. 9, 1

Research output: Contribution to journalArticle

Open Access
File
Microsporidia
parasites
transporter
nucleotides
genes
2017
94 Downloads (Pure)

Evolutionary conservation and in vitro reconstitution of microsporidian iron–sulfur cluster biosynthesis

Freibert, S., Goldberg, A. V., Hacker, C., Molik, S., Dean, P., Williams, T. A., Nakjang, S., Long, S., Sendra, K., Bill, E., Heinz, E., Hirt, R. P., Lucocq, J. M., Embley, T. M. & Lill, R., 4 Jan 2017, In : Nature Communications. 8, p. 13932

Research output: Contribution to journalArticle

Open Access
File
biosynthesis
Biosynthesis
conservation
Conservation
Protein S
2016
81 Downloads (Pure)

Microsporidia: Why Make Nucleotides if You Can Steal Them?

Dean, P., Hirt, R. P. & Embley, T. M., 17 Nov 2016, In : PLoS Pathogens. 12, 11, 13 p., e1005870.

Research output: Contribution to journalArticle

Open Access
File
Microsporidia
Nucleotides
Adenosine Triphosphate
Genome
Nucleotide Transport Proteins

Visualizing the Translocation and Localization of Bacterial Type III Effector Proteins by Using a Genetically Encoded Reporter System

Gawthorne, J. A., Audry, L., Mcquitty, C., Dean, P., Christie, J. M., Enninga, J. & Roe, A. J., 1 May 2016, In : Applied and Environmental Microbiology. 82, 9, p. 2700-2708

Research output: Contribution to journalArticle

Open Access
Bacterial Translocation
translocation
type III secretion system
Oxygen
oxygen
2015

Cultured enterocytes internalise bacteria across their basolateral surface for, pathogen-inhibitable, trafficking to the apical compartment

Dean, P., Quitard, S., Bulmer, D. M., Roe, A. J. & Kenny, B., 1 Dec 2015, In : Scientific Reports. 5, 1, 9 p.

Research output: Contribution to journalArticle

Open Access
Enterocytes
Virulence Factors
Bacteria
Salmonella
Virulence
2014

Plasma Membrane-Located Purine Nucleotide Transport Proteins Are Key Components for Host Exploitation by Microsporidian Intracellular Parasites

Heinz, E., Hacker, C., Dean, P., Mifsud, J., Goldberg, A. V., Williams, T. A., Nakjang, S., Gregory, A., Hirt, R. P., Lucocq, J. M., Kunji, E. R. S. & Embley, T. M., 4 Dec 2014, In : PLoS Pathogens. 10, 12

Research output: Contribution to journalArticle

Open Access
Nucleotide Transport Proteins
Purine Nucleotides
Parasites
Cell Membrane
Nucleotides

Transport proteins of parasitic protists and their role in nutrient salvage

Dean, P., Major, P., Nakjang, S., Hirt, R. P. & Embley, T. M., 29 Apr 2014, In : Frontiers in Plant Science. 5, p. 153

Research output: Contribution to journalArticle

Open Access
transport proteins
transporters
nutrients
parasites
nutrient requirements
2013

A bacterial encoded protein induces extreme multinucleation and cell-cell internalization in intestinal cells

Dean, P. & Kenny, B., 1 Jan 2013, In : Tissue Barriers. 1, 1, p. e22639

Research output: Contribution to journalArticle

Mitochondria
Bacterial Proteins
Pathogens
Escherichia coli
Nucleation

Do Caco-2 subclones provide more appropriate in vitro models for understanding how human enteric pathogens cause disease?

Kenny, B. & Dean, P., 1 Jun 2013, In : Future Microbiology. 8, 6, p. 701-703

Research output: Contribution to journalArticle

In Vitro Techniques

Insights into the Pathogenesis of Enteropathogenic E. coli Using an Improved Intestinal Enterocyte Model

Dean, P., Young, L., Quitard, S., Kenny, B. & Roe, A., 2013, In : PLoS ONE. 8, 1, p. e55284

Research output: Contribution to journalArticle

Enteropathogenic Escherichia coli
enteropathogenic Escherichia coli
Enterocytes
enterocytes
Escherichia coli
2011

Cell-surface nucleolin is sequestered into EPEC microcolonies and may play a role during infection

Dean, P. & Kenny, B., 1 Jun 2011, In : Microbiology. 157, 6, p. 1761-1767

Research output: Contribution to journalArticle

Enteropathogenic Escherichia coli
Infection
Eukaryotic Cells
Microvilli
Nuclear Proteins

Functional domains and motifs of bacterial type III effector proteins and their roles in infection

Dean, P., 1 Nov 2011, In : FEMS Microbiology Reviews. 35, 6, p. 1100-1125

Research output: Contribution to journalArticle

Eukaryotic Cells
Virulence
Ralstonia
Infection
Xanthomonas

The Enteropathogenic E. coli (EPEC) Tir Effector Inhibits NF-κB Activity by Targeting TNFα Receptor-Associated Factors

Ruchaud-sparagano, M., Mühlen, S., Dean, P., Kenny, B. & Monack, D. M. (ed.), 2011, In : PLoS Pathogens. 7, 12, p. e1002414

Research output: Contribution to journalArticle

Tumor Necrosis Factor Receptor-Associated Peptides and Proteins
Enteropathogenic Escherichia coli
Enterocytes
Genomic Islands
Intestinal Diseases