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2019
25 Downloads (Pure)

Pathological Changes to the Subcortical Visual System and its Relationship to Visual Hallucinations in Dementia with Lewy Bodies

Erskine, D., Taylor, J-P., Thomas, A., Collerton, D., McKeith, I., Khundakar, A., Attems, J. & Morris, C., 6 Feb 2019, In : Neuroscience Bulletin. 35, 2, p. 295-300 6 p.

Research output: Contribution to journalArticle

Open Access
File
Lewy Body Disease
Hallucinations
Caregivers
Anatomy
82 Downloads (Pure)

Trichloroethylene and its metabolite TaClo lead to degeneration of substantia nigra dopaminergic neurones: Effects in wild type and human A30P mutant α-synuclein mice

Keane, P. C., Hanson, P. S., Patterson, L., Blain, P. G., Khundakar, A. A., Judge, S. J., Kahle, P. J. & Morris, C. M., 15 Oct 2019, In : Neuroscience Letters. 711, 6 p., 134437.

Research output: Contribution to journalArticle

Open Access
File
Synucleins
Trichloroethylene
Dopamine Agents
Dopaminergic Neurons
Substantia Nigra
2018
3 Citations (Scopus)
98 Downloads (Pure)

Doublecortin expression in CD8+ T-cells and microglia at sites of amyloid-β plaques: A potential role in shaping plaque pathology?

Unger, M. S., Marschallinger, J., Kaindl, J., Klein, B., Johnson, M., Khundakar, A., Roßner, S., Heneka, M. T., Couillard-Despres, S., Rockenstein, E., Masliah, E., Attems, J. & Aigner, L., 31 Aug 2018, In : Alzheimer's and Dementia. 14, 8, p. 1022-1037 16 p.

Research output: Contribution to journalArticle

Open Access
File
Amyloid Plaques
Microglia
Pathology
T-Lymphocytes
Calcium
109 Downloads (Pure)

Molecular changes in the absence of severe pathology in the pulvinar in dementia with Lewy bodies

Erskine, D., Ding, J., Thomas, A. J., Kaganovich, A., Khundakar, A., Hanson, P. S., Taylor, JP., McKeith, I. G., Attems, J., Cookson, M. R. & Morris, C., 23 Mar 2018, In : Movement Disorders : official journal of the Movement Disorder Society. 33, 6, p. 982-991 10 p.

Research output: Contribution to journalArticle

Open Access
File
Pulvinar
Lewy Body Disease
Pathology
Lewy Bodies
RNA Sequence Analysis
2017
6 Citations (Scopus)
106 Downloads (Pure)

Neuronal Loss and Α-Synuclein Pathology in the Superior Colliculus and Its Relationship to Visual Hallucinations in Dementia with Lewy Bodies

Erskine, D., Thomas, A. J., Taylor, J. P., Savage, M. A., Attems, J., McKeith, I. G., Morris, C. M. & Khundakar, A., 1 Jun 2017, In : American Journal of Geriatric Psychiatry. 25, 6, p. 595-604 10 p.

Research output: Contribution to journalArticle

Open Access
File
Synucleins
Lewy Body Disease
Superior Colliculi
Hallucinations
Pathology
2 Citations (Scopus)
120 Downloads (Pure)

Quantitative neuropathology: an update on automated methodologies and implications for large scale cohorts

Walker, L., McAleese, K. E., Johnson, M., Khundakar, A., Erskine, D., Thomas, A. J., McKeith, I. G. & Attems, J., 30 Jun 2017, In : Journal of Neural Transmission. 124, 6, p. 671-683 13 p.

Research output: Contribution to journalArticle

Open Access
File
Lewy Body Disease
Synucleins
Pathology
Alzheimer Disease
Amyloid
3 Citations (Scopus)
116 Downloads (Pure)

Specific patterns of neuronal loss in the pulvinar nucleus in dementia with lewy bodies

Erskine, D., Thomas, A. J., Attems, J., Taylor, J. P., McKeith, I. G., Morris, C. M. & Khundakar, A., 1 Mar 2017, In : Movement Disorders. 32, 3, p. 414-422 9 p.

Research output: Contribution to journalArticle

Open Access
File
Pulvinar
Lewy Body Disease
Hallucinations
Lewy Bodies
Visual Perception
2016
14 Citations (Scopus)
96 Downloads (Pure)

Analysis of primary visual cortex in dementia with Lewy bodies indicates GABAergic involvement associated with recurrent complex visual hallucinations

Khundakar, A., Hanson, P. S., Erskine, D., Lax, N. Z., Roscamp, J., Karyka, E., Tsefou, E., Singh, P., Cockell, S. J., Gribben, A., Ramsay, L., Blain, P. G., Mosimann, U. P., Lett, D. J., Elstner, M., Turnbull, D. M., Xiang, C. C., Brownstein, M. J., O'Brien, J. T., Taylor, J. P. & 4 others, Attems, J., Thomas, A. J., McKeith, I. G. & Morris, C. M., 1 Jan 2016, In : Acta neuropathologica communications. 4, 1, 66.

Research output: Contribution to journalArticle

File
Lewy Body Disease
Hallucinations
Visual Cortex
Interneurons
Vesicular Glutamate Transport Proteins
8 Citations (Scopus)

Changes to the lateral geniculate nucleus in Alzheimer's disease but not dementia with Lewy bodies

Erskine, D., Taylor, J. P., Firbank, M. J., Patterson, L., Onofrj, M., O'Brien, J. T., Mckeith, I. G., Attems, J., Thomas, A. J., Morris, C. M. & Khundakar, A., 1 Jun 2016, In : Neuropathology and Applied Neurobiology. 42, 4, p. 366-376 11 p.

Research output: Contribution to journalArticle

Geniculate Bodies
Lewy Body Disease
Alzheimer Disease
Hallucinations
Pathology
2 Citations (Scopus)
97 Downloads (Pure)

Stereological approaches to dementia research using human brain tissue

Erskine, D. & Khundakar, A., 1 Oct 2016, In : Journal of Chemical Neuroanatomy. 76, p. 73-81 9 p.

Research output: Contribution to journalArticle

File
Dementia
Brain
Research
Neurodegenerative Diseases
Research Personnel
2015
28 Citations (Scopus)

Neuropathology of depression in Alzheimer's disease: Current knowledge and the potential for new treatments

Khundakar, A. A. & Thomas, A. J., 1 Jan 2015, In : Journal of Alzheimer's Disease. 44, 1, p. 27-41 15 p.

Research output: Contribution to journalReview article

Alzheimer Disease
Depression
Dementia
Therapeutics
Antidepressive Agents
62 Downloads (Pure)

Neuropathology of depression in Alzheimer's disease: Current knowledge and the potential for new treatments

Khundakar, A. & Thomas, A. J., 1 Jan 2015, Handbook of Depression in Alzheimer's Disease. Smith, G. S. (ed.). IOS Press, p. 187-201 15 p. (Advances in Alzheimer's Disease; vol. 4).

Research output: Chapter in Book/Report/Conference proceedingChapter

File
Alzheimer Disease
Depression
Dementia
Therapeutics
Antidepressive Agents

Neuropathology of depression in alzheimer’s disease: Current knowledge and the potential for new treatments

Khundakar, A. A. & Thomas, A. J., 1 Jan 2015, Handbook of Depression in Alzheimer's Disease. IOS Press, p. 187-202 16 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Alzheimer Disease
Depression
Dementia
Therapeutics
Antidepressive Agents
2014
9 Citations (Scopus)

Cellular morphometry in late-life depression: A review of postmortem studies

Khundakar, A. & Thomas, A. J., 1 Jan 2014, In : American Journal of Geriatric Psychiatry. 22, 2, p. 122-132 11 p.

Research output: Contribution to journalArticle

Neuroimaging
Neuroglia
Demography
Pathology
Brain
16 Citations (Scopus)
84 Downloads (Pure)

Morphometry of the hippocampal microvasculature in post-stroke and age-related dementias

Burke, M. J. C., Nelson, L., Slade, J. Y., Oakley, A. E., Khundakar, A. & Kalaria, R. N., 1 Jan 2014, In : Neuropathology and Applied Neurobiology. 40, 3, p. 284-295 12 p.

Research output: Contribution to journalArticle

Open Access
File
Microvessels
Dementia
Stroke
Alzheimer Disease
Vascular Dementia
3 Citations (Scopus)
116 Downloads (Pure)

Neuron volumes in hippocampal subfields in delayed poststroke and aging-related dementias

Gemmell, E., Tam, E., Allan, L., Hall, R., Khundakar, A., Oakley, A. E., Thomas, A., Deramecourt, V. & Kalaria, R. N., 1 Jan 2014, In : Journal of Neuropathology and Experimental Neurology. 73, 4, p. 305-311 7 p.

Research output: Contribution to journalArticle

Open Access
File
Dementia
Neurons
Stroke
Alzheimer Disease
Vascular Dementia
16 Citations (Scopus)
83 Downloads (Pure)

Pyramidal neurons of the prefrontal cortex in post-stroke, vascular and other ageing-related dementias

Foster, V., Oakley, A. E., Slade, J. Y., Hall, R., Polvikoski, T. M., Burke, M., Thomas, A. J., Khundakar, A., Allan, L. M. & Kalaria, R. N., 1 Jan 2014, In : Brain. 137, 9, p. 2509-2521 13 p.

Research output: Contribution to journalArticle

File
Pyramidal Cells
Prefrontal Cortex
Blood Vessels
Dementia
Vascular Dementia
3 Citations (Scopus)
58 Downloads (Pure)

The role of 5-hydroxytryptamine receptor subtypes in the regulation of brain-derived neurotrophic factor gene expression

Zetterström, T. S. C., Coppell, A. A. & Khundakar, A., 1 Jan 2014, In : Journal of Pharmacy and Pharmacology. 66, 1, p. 53-61 9 p.

Research output: Contribution to journalArticle

Open Access
File
Fluoxetine
Serotonin Receptors
Brain-Derived Neurotrophic Factor
Serotonin
Gene Expression
2013
4 Citations (Scopus)

Effects of repeated 5-HT6 receptor stimulation on BDNF gene expression and cell survival

de Foubert, G., Khundakar, A. & Zetterström, T. S., 11 Oct 2013, In : Neuroscience Letters. 553, p. 211-215 5 p.

Research output: Contribution to journalArticle

Brain-Derived Neurotrophic Factor
Cell Survival
Gene Expression
Neurogenesis
Antidepressive Agents

The Possible Applications (and Pitfalls!) of Stereological Analysis in Postmortem Brain Research

Khundakar, A. & Thomas, A. J., 25 Nov 2013, Neurostereology: Unbiased Stereology of Neural Systems. Wiley, p. 129-138 10 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Brain
Research
Autolysis
Dissection
Neurons
2012
50 Citations (Scopus)

Hippocampal neuronal atrophy and cognitive function in delayed poststroke and aging-related dementias

Gemmell, E., Bosomworth, H., Allan, L., Hall, R., Khundakar, A., Oakley, A. E., Deramecourt, V., Polvikoski, T. M., O'Brien, J. T. & Kalaria, R. N., 1 Mar 2012, In : Stroke. 43, 3, p. 808-814 7 p.

Research output: Contribution to journalArticle

Cognition
Atrophy
Dementia
Vascular Dementia
Alzheimer Disease
2011
18 Citations (Scopus)

A morphometric examination of neuronal and glial cell pathology in the orbitofrontal cortex in late-life depression

Khundakar, A., Morris, C., Oakley, A. & Thomas, A. J., 1 Feb 2011, In : International Psychogeriatrics. 23, 1, p. 132-140 9 p.

Research output: Contribution to journalArticle

Prefrontal Cortex
Neuroglia
Pathology
Pyramidal Cells
Cell Count
17 Citations (Scopus)

Cellular pathology within the anterior cingulate cortex of patients with late-life depression: A morphometric study

Khundakar, A., Morris, C. M., Oakley, A. E. & Thomas, A. J., 30 Nov 2011, In : Psychiatry Research - Neuroimaging. 194, 2, p. 184-189 6 p.

Research output: Contribution to journalArticle

Gyrus Cinguli
Pyramidal Cells
Pathology
Cell Size
Neuroglia
14 Citations (Scopus)

Effects of GABAB ligands alone and in combination with paroxetine on hippocampal BDNF gene expression

Khundakar, A. & Zetterström, T. S. C., 5 Dec 2011, In : European Journal of Pharmacology. 671, 1-3, p. 33-38 6 p.

Research output: Contribution to journalArticle

Paroxetine
Brain-Derived Neurotrophic Factor
Ligands
Gene Expression
Hippocampus
1 Citation (Scopus)
Facilitative Glucose Transport Proteins
Transforming Growth Factors
Prefrontal Cortex
Pathologic Processes
Blood Vessels
25 Citations (Scopus)

Morphometric analysis of neuronal and glial cell pathology in the caudate nucleus in late-life depression

Khundakar, A., Morris, C., Oakley, A. & Thomas, A. J., 1 Jan 2011, In : American Journal of Geriatric Psychiatry. 19, 2, p. 132-141 10 p.

Research output: Contribution to journalArticle

Caudate Nucleus
Neuroglia
Pathology
Brain
Neuroimaging
11 Citations (Scopus)
Parvalbumins
Interneurons
Prefrontal Cortex
Calbindin 2
gamma-Aminobutyric Acid