A growing awareness is brought that the safety and security of Industrial Control Systems (ICS) cannot be dealt with in isolation, and the safety and security of industrial control protocols (ICPs) should be considered jointly. Fuzz test- ing (fuzzing) for the ICP is a common way to discover whether the ICP itself is designed and implemented with flaws and network security vulnerability. Traditional fuzzing methods promote the safety and security testing of ICPs, and many of them have practical applications. However, most traditional fuzzing methods rely heavily on the specification of ICPs, which makes the test process a costly, time-consuming, troublesome and boring task. And the task is hard to repeat if the speci- fication does not exist. In this study, we propose a smart and automated protocol fuzzing methodology based on improved Deep Convolution Generative Adversarial Network (DCGAN) and give a series of performance metrics. An automated and intelligent fuzzing framework BLSTM-DCNNFuzz for application is designed. Several typical ICPs, including Modbus and EtherCAT, are applied to test the effectiveness and efficiency of our framework. Experiment results show that our method- ology outperforms the existing ones like General Purpose Fuzzer(GPF) and other deep learning based fuzzing methods in convenience, effectiveness, and efficiency.