A morphometric examination of neuronal and glial cell pathology in the orbitofrontal cortex in late-life depression

Ahmad Khundakar, Christopher Morris, Arthur Oakley, Alan J. Thomas

    Research output: Contribution to journalArticle

    18 Citations (Scopus)

    Abstract

    Background: The orbitofrontal cortex has been implicated as a key component in depression by several imaging studies. This study aims to examine morphometrically glial cell and neuronal density and neuronal volume in the orbitofrontal cortex of late-life major depression patients. Methods: Post mortem tissue from 13 patients with major depression and 11 matched controls was obtained and analyzed using the optical disector and nucleator methods. Results: No changes were found in glial cell, pyramidal or non-pyramidal neuron density, or in non-pyramidal and pyramidal neuron volume in the orbitofrontal cortex. Conclusions: Based on previous findings, this study suggests variability in morphological changes within the orbitofrontal cortex, as well as the prefrontal cortex as a whole.

    Original languageEnglish
    Pages (from-to)132-140
    Number of pages9
    JournalInternational Psychogeriatrics
    Volume23
    Issue number1
    DOIs
    Publication statusPublished - 1 Feb 2011

    Fingerprint Dive into the research topics of 'A morphometric examination of neuronal and glial cell pathology in the orbitofrontal cortex in late-life depression'. Together they form a unique fingerprint.

  • Cite this