A morphometric examination of neuronal and glial cell pathology in the orbitofrontal cortex in late-life depression

Ahmad Khundakar, Christopher Morris, Arthur Oakley, Alan J. Thomas

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18 Citations (Scopus)

Abstract

Background: The orbitofrontal cortex has been implicated as a key component in depression by several imaging studies. This study aims to examine morphometrically glial cell and neuronal density and neuronal volume in the orbitofrontal cortex of late-life major depression patients. Methods: Post mortem tissue from 13 patients with major depression and 11 matched controls was obtained and analyzed using the optical disector and nucleator methods. Results: No changes were found in glial cell, pyramidal or non-pyramidal neuron density, or in non-pyramidal and pyramidal neuron volume in the orbitofrontal cortex. Conclusions: Based on previous findings, this study suggests variability in morphological changes within the orbitofrontal cortex, as well as the prefrontal cortex as a whole.

Original languageEnglish
Pages (from-to)132-140
Number of pages9
JournalInternational Psychogeriatrics
Volume23
Issue number1
DOIs
Publication statusPublished - 1 Feb 2011

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Prefrontal Cortex
Neuroglia
Pathology
Pyramidal Cells
Cell Count
Neurons

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A morphometric examination of neuronal and glial cell pathology in the orbitofrontal cortex in late-life depression. / Khundakar, Ahmad; Morris, Christopher; Oakley, Arthur; Thomas, Alan J.

In: International Psychogeriatrics, Vol. 23, No. 1, 01.02.2011, p. 132-140.

Research output: Contribution to journalArticleResearchpeer-review

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