A natural solution to photoprotection and isolation of the potent polyene antibiotic, marinomycin A

Christopher Bailey, Joseph Scott Zarins-Tutt, Matthias Agbo, Hong Gao, Alberto Diego-Taboada, Maoluo Gan, Refaat Hamed, Emily Abraham, Grahame Mackenzie, P. Andrew Evans, Rebecca Goss

Research output: Contribution to journalArticleResearchpeer-review

Abstract

The photoprotection and isolation of marinomycin A using sporopollenin exine capsules (SpECs) derived
from the spores of the plant Lycopodium clavatum is described. The marinomycins have a particularly
short half-life in natural light, which severely impacts their potential biological utility given that they
display potent antibiotic and anticancer activity. The SpEC encapsulation of the marinomycin A
dramatically increases the half-life of the polyene macrodiolide to the direct exposure to UV radiation by
several orders of magnitude, thereby making this a potentially useful strategy for other light sensitive
bioactive agents. In addition, we report that the SpECs can also be used to selectively extract culture
broths that contain the marinomycins, which provides a significantly higher recovery than with
conventional XAD resins and provides concomitant photoprotection.
Original languageEnglish
JournalChemical Science
Early online date21 May 2019
Publication statusE-pub ahead of print - 21 May 2019

Fingerprint

Polyenes
Capsules
Anti-Bacterial Agents
Encapsulation
Ultraviolet radiation
Resins
Recovery
sporopollenin
marinomycin A

Cite this

Bailey, C., Zarins-Tutt, J. S., Agbo, M., Gao, H., Diego-Taboada, A., Gan, M., ... Goss, R. (2019). A natural solution to photoprotection and isolation of the potent polyene antibiotic, marinomycin A. Chemical Science.
Bailey, Christopher ; Zarins-Tutt, Joseph Scott ; Agbo, Matthias ; Gao, Hong ; Diego-Taboada, Alberto ; Gan, Maoluo ; Hamed, Refaat ; Abraham, Emily ; Mackenzie, Grahame ; Evans, P. Andrew ; Goss, Rebecca. / A natural solution to photoprotection and isolation of the potent polyene antibiotic, marinomycin A. In: Chemical Science. 2019.
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abstract = "The photoprotection and isolation of marinomycin A using sporopollenin exine capsules (SpECs) derivedfrom the spores of the plant Lycopodium clavatum is described. The marinomycins have a particularlyshort half-life in natural light, which severely impacts their potential biological utility given that theydisplay potent antibiotic and anticancer activity. The SpEC encapsulation of the marinomycin Adramatically increases the half-life of the polyene macrodiolide to the direct exposure to UV radiation byseveral orders of magnitude, thereby making this a potentially useful strategy for other light sensitivebioactive agents. In addition, we report that the SpECs can also be used to selectively extract culturebroths that contain the marinomycins, which provides a significantly higher recovery than withconventional XAD resins and provides concomitant photoprotection.",
author = "Christopher Bailey and Zarins-Tutt, {Joseph Scott} and Matthias Agbo and Hong Gao and Alberto Diego-Taboada and Maoluo Gan and Refaat Hamed and Emily Abraham and Grahame Mackenzie and Evans, {P. Andrew} and Rebecca Goss",
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Bailey, C, Zarins-Tutt, JS, Agbo, M, Gao, H, Diego-Taboada, A, Gan, M, Hamed, R, Abraham, E, Mackenzie, G, Evans, PA & Goss, R 2019, 'A natural solution to photoprotection and isolation of the potent polyene antibiotic, marinomycin A' Chemical Science.

A natural solution to photoprotection and isolation of the potent polyene antibiotic, marinomycin A. / Bailey, Christopher; Zarins-Tutt, Joseph Scott; Agbo, Matthias; Gao, Hong; Diego-Taboada, Alberto; Gan, Maoluo; Hamed, Refaat; Abraham, Emily; Mackenzie, Grahame; Evans, P. Andrew; Goss, Rebecca.

In: Chemical Science, 21.05.2019.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - A natural solution to photoprotection and isolation of the potent polyene antibiotic, marinomycin A

AU - Bailey, Christopher

AU - Zarins-Tutt, Joseph Scott

AU - Agbo, Matthias

AU - Gao, Hong

AU - Diego-Taboada, Alberto

AU - Gan, Maoluo

AU - Hamed, Refaat

AU - Abraham, Emily

AU - Mackenzie, Grahame

AU - Evans, P. Andrew

AU - Goss, Rebecca

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N2 - The photoprotection and isolation of marinomycin A using sporopollenin exine capsules (SpECs) derivedfrom the spores of the plant Lycopodium clavatum is described. The marinomycins have a particularlyshort half-life in natural light, which severely impacts their potential biological utility given that theydisplay potent antibiotic and anticancer activity. The SpEC encapsulation of the marinomycin Adramatically increases the half-life of the polyene macrodiolide to the direct exposure to UV radiation byseveral orders of magnitude, thereby making this a potentially useful strategy for other light sensitivebioactive agents. In addition, we report that the SpECs can also be used to selectively extract culturebroths that contain the marinomycins, which provides a significantly higher recovery than withconventional XAD resins and provides concomitant photoprotection.

AB - The photoprotection and isolation of marinomycin A using sporopollenin exine capsules (SpECs) derivedfrom the spores of the plant Lycopodium clavatum is described. The marinomycins have a particularlyshort half-life in natural light, which severely impacts their potential biological utility given that theydisplay potent antibiotic and anticancer activity. The SpEC encapsulation of the marinomycin Adramatically increases the half-life of the polyene macrodiolide to the direct exposure to UV radiation byseveral orders of magnitude, thereby making this a potentially useful strategy for other light sensitivebioactive agents. In addition, we report that the SpECs can also be used to selectively extract culturebroths that contain the marinomycins, which provides a significantly higher recovery than withconventional XAD resins and provides concomitant photoprotection.

M3 - Article

JO - Chemical Science

JF - Chemical Science

SN - 2041-6520

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