Abstract
The photoprotection and isolation of marinomycin A using sporopollenin exine capsules (SpECs) derived
from the spores of the plant Lycopodium clavatum is described. The marinomycins have a particularly
short half-life in natural light, which severely impacts their potential biological utility given that they
display potent antibiotic and anticancer activity. The SpEC encapsulation of the marinomycin A
dramatically increases the half-life of the polyene macrodiolide to the direct exposure to UV radiation by
several orders of magnitude, thereby making this a potentially useful strategy for other light sensitive
bioactive agents. In addition, we report that the SpECs can also be used to selectively extract culture
broths that contain the marinomycins, which provides a significantly higher recovery than with
conventional XAD resins and provides concomitant photoprotection.
from the spores of the plant Lycopodium clavatum is described. The marinomycins have a particularly
short half-life in natural light, which severely impacts their potential biological utility given that they
display potent antibiotic and anticancer activity. The SpEC encapsulation of the marinomycin A
dramatically increases the half-life of the polyene macrodiolide to the direct exposure to UV radiation by
several orders of magnitude, thereby making this a potentially useful strategy for other light sensitive
bioactive agents. In addition, we report that the SpECs can also be used to selectively extract culture
broths that contain the marinomycins, which provides a significantly higher recovery than with
conventional XAD resins and provides concomitant photoprotection.
| Original language | English |
|---|---|
| Pages (from-to) | 7549-7553 |
| Number of pages | 5 |
| Journal | Chemical Science |
| Volume | 10 |
| Issue number | 32 |
| Early online date | 21 May 2019 |
| DOIs | |
| Publication status | E-pub ahead of print - 21 May 2019 |