A novel point of care diagnostic device: Impedimetric detection of a biomarker in whole blood

Amanda McMurray, Zulfiqur Ali, Jan Kyselovik, Christopher A. Mills, Nicole Jaffrezic-Renault, Hunor Santha, Christof Strohhöfer

Research output: Chapter in Book/Report/Conference proceedingConference contributionResearch

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Abstract

There is an unmet medical need for a more reliable and earlier assessment of patients suspected of having a deep vein thrombosis. We describe a novel approach which is developing a highly reliable, accurate, portable and handheld prototype medical diagnostic device to improve radically the speed, accuracy and reliability with which DVT and related blood clotting conditions can be assessed. The device will measure whole blood concentration of D-dimer, a recognized biomarker of increased blood clotting activity, and through innovation in the development of a novel detection, measurement and reporting system, will offer the opportunity to use the test in the point of care setting. The device combines innovation in antibody bio-engineering for high specificity immunoassay-based diagnostics and nano/micro engineered impedimetric analysis electrodes incorporating a biocompatible polymer substrate with development of a disposable microfluidic manifold specifically enabling diagnostics at the point-of-first-contact.
Original languageEnglish
Title of host publicationProceedings of the 29th annual international conference of the IEEE EMBS
PublisherIEEE
Pages115-118
Publication statusPublished - 2007
Event29th Annual International Conference of the IEEE Engineering in Medicine and Biology Society - Lyon, France
Duration: 23 Aug 200726 Aug 2007
Conference number: 29

Conference

Conference29th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
CountryFrance
CityLyon
Period23/08/0726/08/07

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Point-of-Care Systems
Biomarkers
Blood Coagulation
Equipment and Supplies
Bioengineering
Microfluidics
Immunoassay
Venous Thrombosis
Polymers
Electrodes
Antibodies

Bibliographical note

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Cite this

McMurray, A., Ali, Z., Kyselovik, J., Mills, C. A., Jaffrezic-Renault, N., Santha, H., & Strohhöfer, C. (2007). A novel point of care diagnostic device: Impedimetric detection of a biomarker in whole blood. In Proceedings of the 29th annual international conference of the IEEE EMBS (pp. 115-118). IEEE.
McMurray, Amanda ; Ali, Zulfiqur ; Kyselovik, Jan ; Mills, Christopher A. ; Jaffrezic-Renault, Nicole ; Santha, Hunor ; Strohhöfer, Christof. / A novel point of care diagnostic device: Impedimetric detection of a biomarker in whole blood. Proceedings of the 29th annual international conference of the IEEE EMBS. IEEE, 2007. pp. 115-118
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title = "A novel point of care diagnostic device: Impedimetric detection of a biomarker in whole blood",
abstract = "There is an unmet medical need for a more reliable and earlier assessment of patients suspected of having a deep vein thrombosis. We describe a novel approach which is developing a highly reliable, accurate, portable and handheld prototype medical diagnostic device to improve radically the speed, accuracy and reliability with which DVT and related blood clotting conditions can be assessed. The device will measure whole blood concentration of D-dimer, a recognized biomarker of increased blood clotting activity, and through innovation in the development of a novel detection, measurement and reporting system, will offer the opportunity to use the test in the point of care setting. The device combines innovation in antibody bio-engineering for high specificity immunoassay-based diagnostics and nano/micro engineered impedimetric analysis electrodes incorporating a biocompatible polymer substrate with development of a disposable microfluidic manifold specifically enabling diagnostics at the point-of-first-contact.",
author = "Amanda McMurray and Zulfiqur Ali and Jan Kyselovik and Mills, {Christopher A.} and Nicole Jaffrezic-Renault and Hunor Santha and Christof Strohh{\"o}fer",
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McMurray, A, Ali, Z, Kyselovik, J, Mills, CA, Jaffrezic-Renault, N, Santha, H & Strohhöfer, C 2007, A novel point of care diagnostic device: Impedimetric detection of a biomarker in whole blood. in Proceedings of the 29th annual international conference of the IEEE EMBS. IEEE, pp. 115-118, 29th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Lyon, France, 23/08/07.

A novel point of care diagnostic device: Impedimetric detection of a biomarker in whole blood. / McMurray, Amanda; Ali, Zulfiqur; Kyselovik, Jan; Mills, Christopher A.; Jaffrezic-Renault, Nicole; Santha, Hunor; Strohhöfer, Christof.

Proceedings of the 29th annual international conference of the IEEE EMBS. IEEE, 2007. p. 115-118.

Research output: Chapter in Book/Report/Conference proceedingConference contributionResearch

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AU - Strohhöfer, Christof

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N2 - There is an unmet medical need for a more reliable and earlier assessment of patients suspected of having a deep vein thrombosis. We describe a novel approach which is developing a highly reliable, accurate, portable and handheld prototype medical diagnostic device to improve radically the speed, accuracy and reliability with which DVT and related blood clotting conditions can be assessed. The device will measure whole blood concentration of D-dimer, a recognized biomarker of increased blood clotting activity, and through innovation in the development of a novel detection, measurement and reporting system, will offer the opportunity to use the test in the point of care setting. The device combines innovation in antibody bio-engineering for high specificity immunoassay-based diagnostics and nano/micro engineered impedimetric analysis electrodes incorporating a biocompatible polymer substrate with development of a disposable microfluidic manifold specifically enabling diagnostics at the point-of-first-contact.

AB - There is an unmet medical need for a more reliable and earlier assessment of patients suspected of having a deep vein thrombosis. We describe a novel approach which is developing a highly reliable, accurate, portable and handheld prototype medical diagnostic device to improve radically the speed, accuracy and reliability with which DVT and related blood clotting conditions can be assessed. The device will measure whole blood concentration of D-dimer, a recognized biomarker of increased blood clotting activity, and through innovation in the development of a novel detection, measurement and reporting system, will offer the opportunity to use the test in the point of care setting. The device combines innovation in antibody bio-engineering for high specificity immunoassay-based diagnostics and nano/micro engineered impedimetric analysis electrodes incorporating a biocompatible polymer substrate with development of a disposable microfluidic manifold specifically enabling diagnostics at the point-of-first-contact.

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McMurray A, Ali Z, Kyselovik J, Mills CA, Jaffrezic-Renault N, Santha H et al. A novel point of care diagnostic device: Impedimetric detection of a biomarker in whole blood. In Proceedings of the 29th annual international conference of the IEEE EMBS. IEEE. 2007. p. 115-118