A novel point of care diagnostic device: Impedimetric detection of a biomarker in whole blood

Amanda McMurray, Zulfiqur Ali, Jan Kyselovik, Christopher A. Mills, Nicole Jaffrezic-Renault, Hunor Santha, Christof Strohhöfer

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    Abstract

    There is an unmet medical need for a more reliable and earlier assessment of patients suspected of having a deep vein thrombosis. We describe a novel approach which is developing a highly reliable, accurate, portable and handheld prototype medical diagnostic device to improve radically the speed, accuracy and reliability with which DVT and related blood clotting conditions can be assessed. The device will measure whole blood concentration of D-dimer, a recognized biomarker of increased blood clotting activity, and through innovation in the development of a novel detection, measurement and reporting system, will offer the opportunity to use the test in the point of care setting. The device combines innovation in antibody bio-engineering for high specificity immunoassay-based diagnostics and nano/micro engineered impedimetric analysis electrodes incorporating a biocompatible polymer substrate with development of a disposable microfluidic manifold specifically enabling diagnostics at the point-of-first-contact.
    Original languageEnglish
    Title of host publicationProceedings of the 29th annual international conference of the IEEE EMBS
    PublisherIEEE
    Pages115-118
    Publication statusPublished - 2007
    Event29th Annual International Conference of the IEEE Engineering in Medicine and Biology Society - Lyon, France
    Duration: 23 Aug 200726 Aug 2007
    Conference number: 29

    Conference

    Conference29th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
    CountryFrance
    CityLyon
    Period23/08/0726/08/07

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    McMurray, A., Ali, Z., Kyselovik, J., Mills, C. A., Jaffrezic-Renault, N., Santha, H., & Strohhöfer, C. (2007). A novel point of care diagnostic device: Impedimetric detection of a biomarker in whole blood. In Proceedings of the 29th annual international conference of the IEEE EMBS (pp. 115-118). IEEE.