A tandem C-H insertion-acetal cleavage sequence: stereocontrolled synthesis of substituted tetrahydrofurans

A Garbi, JG Mina, PG Steel, T Longstaff, S Vile

Research output: Contribution to journalArticle

Abstract

A short sequence involving Rh(II) mediated carbene insertion followed by Lewis acid promoted reductive acetal cleavage with Et3SiH provides a stereoselective method for the construction of 2,3,5-trisubstituted tetrahydrofuran rings.
Original languageEnglish
Pages (from-to)7175-7178
Number of pages4
JournalTetrahedron Letters
Volume46
Issue number42
DOIs
Publication statusPublished - 17 Oct 2005

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