A tandem C-H insertion-acetal cleavage sequence: stereocontrolled synthesis of substituted tetrahydrofurans

A Garbi, JG Mina, PG Steel, T Longstaff, S Vile

    Research output: Contribution to journalArticle

    Abstract

    A short sequence involving Rh(II) mediated carbene insertion followed by Lewis acid promoted reductive acetal cleavage with Et3SiH provides a stereoselective method for the construction of 2,3,5-trisubstituted tetrahydrofuran rings.
    Original languageEnglish
    Pages (from-to)7175-7178
    Number of pages4
    JournalTetrahedron Letters
    Volume46
    Issue number42
    DOIs
    Publication statusPublished - 17 Oct 2005

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