Acceptability, Feasibility and Preliminary Evaluation of a Novel, Personalised, Home based Physical Activity Intervention for Chronic Heart Failure (Active-at-Home-HF): A Pilot Study

Nduka Okwose, Leah Avery, Nicola O'Brien, Sophie Cassidy, Sarah Charman, Kristian Bailey, Lazar Velicki, Iacopo Olivotto, Paul Brennan, Guy MacGowan, Djordje Jakovljevic

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Abstract

Purpose

Less than 10% of heart failure patients in the UK participate in cardiac rehabilitation programmes. The present pilot study evaluated feasibility, acceptability and physiological effects of a novel, personalised, home-based physical activity intervention in chronic heart failure.
Methods

Twenty patients (68 ± 7 years old, 20% females) with stable chronic heart failure due to reduced left ventricular ejection fraction (31 ± 8 %) participated in a single-group, pilot study assessing the feasibility and acceptability of a 12-week personalised home-based physical activity intervention aiming to increase daily number of steps by 2000 from baseline (Active-at-Home-HF). Patients completed cardiopulmonary exercise testing with non-invasive gas exchange and haemodynamic measurements and quality of life questionnaire pre- and post-intervention. Patients were supported weekly via telephone and average weekly step count data collected using pedometers.
Results

Forty-three patients were screened and 20 recruited into the study. Seventeen patients (85%) completed the intervention, and 15 (75%) achieved the target step count. Average step count per day increased significantly from baseline to 3 weeks by 2546 (5108 ± 3064 to 7654 ± 3849, P = 0.03, n = 17) and was maintained until week 12 (9022 ± 3942). Following completion of the intervention, no adverse events were recorded and quality of life improved by 4 points (26 ± 18 vs. 22 ± 19). Peak exercise stroke volume increased by 19% (127 ± 34 vs. 151 ± 34 m/beat, P = 0.05), while cardiac index increased by 12% (6.8 ± 1.5 vs. 7.6 ± 2.0 L/min/m2, P = 0.19). Workload and oxygen consumption at anaerobic threshold also increased by 16% (49 ± 16 vs. 59 ± 14 watts, P = 0.01) and 10% (11.5 ± 2.9 vs. 12.8 ± 2.2 ml/kg/min, P = 0.39).
Conclusion

The Active-at-Home-HF intervention is feasible, acceptable and effective for increasing physical activity in CHF. It may lead to improvements in quality of life, exercise tolerance and haemodynamic function.
Original languageEnglish
Number of pages9
JournalSports Medicine - Open
Volume5
Issue number45
DOIs
Publication statusPublished - 27 Nov 2019

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Heart Failure
Exercise
Quality of Life
Stroke Volume
Hemodynamics
Anaerobic Threshold
Exercise Tolerance
Workload
Telephone
Oxygen Consumption
Gases

Cite this

Okwose, Nduka ; Avery, Leah ; O'Brien, Nicola ; Cassidy, Sophie ; Charman, Sarah ; Bailey, Kristian ; Velicki, Lazar ; Olivotto, Iacopo ; Brennan, Paul ; MacGowan, Guy ; Jakovljevic, Djordje. / Acceptability, Feasibility and Preliminary Evaluation of a Novel, Personalised, Home based Physical Activity Intervention for Chronic Heart Failure (Active-at-Home-HF): A Pilot Study. In: Sports Medicine - Open. 2019 ; Vol. 5, No. 45.
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title = "Acceptability, Feasibility and Preliminary Evaluation of a Novel, Personalised, Home based Physical Activity Intervention for Chronic Heart Failure (Active-at-Home-HF):: A Pilot Study",
abstract = "PurposeLess than 10{\%} of heart failure patients in the UK participate in cardiac rehabilitation programmes. The present pilot study evaluated feasibility, acceptability and physiological effects of a novel, personalised, home-based physical activity intervention in chronic heart failure.MethodsTwenty patients (68 ± 7 years old, 20{\%} females) with stable chronic heart failure due to reduced left ventricular ejection fraction (31 ± 8 {\%}) participated in a single-group, pilot study assessing the feasibility and acceptability of a 12-week personalised home-based physical activity intervention aiming to increase daily number of steps by 2000 from baseline (Active-at-Home-HF). Patients completed cardiopulmonary exercise testing with non-invasive gas exchange and haemodynamic measurements and quality of life questionnaire pre- and post-intervention. Patients were supported weekly via telephone and average weekly step count data collected using pedometers.ResultsForty-three patients were screened and 20 recruited into the study. Seventeen patients (85{\%}) completed the intervention, and 15 (75{\%}) achieved the target step count. Average step count per day increased significantly from baseline to 3 weeks by 2546 (5108 ± 3064 to 7654 ± 3849, P = 0.03, n = 17) and was maintained until week 12 (9022 ± 3942). Following completion of the intervention, no adverse events were recorded and quality of life improved by 4 points (26 ± 18 vs. 22 ± 19). Peak exercise stroke volume increased by 19{\%} (127 ± 34 vs. 151 ± 34 m/beat, P = 0.05), while cardiac index increased by 12{\%} (6.8 ± 1.5 vs. 7.6 ± 2.0 L/min/m2, P = 0.19). Workload and oxygen consumption at anaerobic threshold also increased by 16{\%} (49 ± 16 vs. 59 ± 14 watts, P = 0.01) and 10{\%} (11.5 ± 2.9 vs. 12.8 ± 2.2 ml/kg/min, P = 0.39).ConclusionThe Active-at-Home-HF intervention is feasible, acceptable and effective for increasing physical activity in CHF. It may lead to improvements in quality of life, exercise tolerance and haemodynamic function.",
author = "Nduka Okwose and Leah Avery and Nicola O'Brien and Sophie Cassidy and Sarah Charman and Kristian Bailey and Lazar Velicki and Iacopo Olivotto and Paul Brennan and Guy MacGowan and Djordje Jakovljevic",
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Acceptability, Feasibility and Preliminary Evaluation of a Novel, Personalised, Home based Physical Activity Intervention for Chronic Heart Failure (Active-at-Home-HF): A Pilot Study. / Okwose, Nduka; Avery, Leah; O'Brien, Nicola; Cassidy, Sophie; Charman, Sarah; Bailey, Kristian; Velicki, Lazar; Olivotto, Iacopo; Brennan, Paul; MacGowan, Guy; Jakovljevic, Djordje.

In: Sports Medicine - Open, Vol. 5, No. 45, 27.11.2019.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Acceptability, Feasibility and Preliminary Evaluation of a Novel, Personalised, Home based Physical Activity Intervention for Chronic Heart Failure (Active-at-Home-HF):

T2 - A Pilot Study

AU - Okwose, Nduka

AU - Avery, Leah

AU - O'Brien, Nicola

AU - Cassidy, Sophie

AU - Charman, Sarah

AU - Bailey, Kristian

AU - Velicki, Lazar

AU - Olivotto, Iacopo

AU - Brennan, Paul

AU - MacGowan, Guy

AU - Jakovljevic, Djordje

PY - 2019/11/27

Y1 - 2019/11/27

N2 - PurposeLess than 10% of heart failure patients in the UK participate in cardiac rehabilitation programmes. The present pilot study evaluated feasibility, acceptability and physiological effects of a novel, personalised, home-based physical activity intervention in chronic heart failure.MethodsTwenty patients (68 ± 7 years old, 20% females) with stable chronic heart failure due to reduced left ventricular ejection fraction (31 ± 8 %) participated in a single-group, pilot study assessing the feasibility and acceptability of a 12-week personalised home-based physical activity intervention aiming to increase daily number of steps by 2000 from baseline (Active-at-Home-HF). Patients completed cardiopulmonary exercise testing with non-invasive gas exchange and haemodynamic measurements and quality of life questionnaire pre- and post-intervention. Patients were supported weekly via telephone and average weekly step count data collected using pedometers.ResultsForty-three patients were screened and 20 recruited into the study. Seventeen patients (85%) completed the intervention, and 15 (75%) achieved the target step count. Average step count per day increased significantly from baseline to 3 weeks by 2546 (5108 ± 3064 to 7654 ± 3849, P = 0.03, n = 17) and was maintained until week 12 (9022 ± 3942). Following completion of the intervention, no adverse events were recorded and quality of life improved by 4 points (26 ± 18 vs. 22 ± 19). Peak exercise stroke volume increased by 19% (127 ± 34 vs. 151 ± 34 m/beat, P = 0.05), while cardiac index increased by 12% (6.8 ± 1.5 vs. 7.6 ± 2.0 L/min/m2, P = 0.19). Workload and oxygen consumption at anaerobic threshold also increased by 16% (49 ± 16 vs. 59 ± 14 watts, P = 0.01) and 10% (11.5 ± 2.9 vs. 12.8 ± 2.2 ml/kg/min, P = 0.39).ConclusionThe Active-at-Home-HF intervention is feasible, acceptable and effective for increasing physical activity in CHF. It may lead to improvements in quality of life, exercise tolerance and haemodynamic function.

AB - PurposeLess than 10% of heart failure patients in the UK participate in cardiac rehabilitation programmes. The present pilot study evaluated feasibility, acceptability and physiological effects of a novel, personalised, home-based physical activity intervention in chronic heart failure.MethodsTwenty patients (68 ± 7 years old, 20% females) with stable chronic heart failure due to reduced left ventricular ejection fraction (31 ± 8 %) participated in a single-group, pilot study assessing the feasibility and acceptability of a 12-week personalised home-based physical activity intervention aiming to increase daily number of steps by 2000 from baseline (Active-at-Home-HF). Patients completed cardiopulmonary exercise testing with non-invasive gas exchange and haemodynamic measurements and quality of life questionnaire pre- and post-intervention. Patients were supported weekly via telephone and average weekly step count data collected using pedometers.ResultsForty-three patients were screened and 20 recruited into the study. Seventeen patients (85%) completed the intervention, and 15 (75%) achieved the target step count. Average step count per day increased significantly from baseline to 3 weeks by 2546 (5108 ± 3064 to 7654 ± 3849, P = 0.03, n = 17) and was maintained until week 12 (9022 ± 3942). Following completion of the intervention, no adverse events were recorded and quality of life improved by 4 points (26 ± 18 vs. 22 ± 19). Peak exercise stroke volume increased by 19% (127 ± 34 vs. 151 ± 34 m/beat, P = 0.05), while cardiac index increased by 12% (6.8 ± 1.5 vs. 7.6 ± 2.0 L/min/m2, P = 0.19). Workload and oxygen consumption at anaerobic threshold also increased by 16% (49 ± 16 vs. 59 ± 14 watts, P = 0.01) and 10% (11.5 ± 2.9 vs. 12.8 ± 2.2 ml/kg/min, P = 0.39).ConclusionThe Active-at-Home-HF intervention is feasible, acceptable and effective for increasing physical activity in CHF. It may lead to improvements in quality of life, exercise tolerance and haemodynamic function.

U2 - 10.1186/s40798-019-0216-x

DO - 10.1186/s40798-019-0216-x

M3 - Article

VL - 5

JO - Sports Medicine - Open

JF - Sports Medicine - Open

SN - 2198-9761

IS - 45

ER -