Accuracy of T1 measurements at high temporal resolution: Feasibility of dynamic measurement of blood T1 after contrast administration

The purpose of this work was to optimize a technique to measure blood T1 dynamically after contrast agent administration with a high temporal resolution. This technique uses a 90°prepared gradient-echo sequence and has a temporal resolution of one T1 measurement per cardiac cycle. The non-ideal excitation slice profiles on the estimation of T1 were evaluated by theoretical simulations and used to obtain corrected blood T1 values. The technique was validated on phantom and in vivo pig studies, which demonstrated significant improvement on the accuracy of the dynamic T1 measurement method after slice profile correction. This technique may find important applications in studying the dynamic blood T1 after injection of various contrast agents.