An improved mechanism-based cross-linker for multiplexed kinase detection and inhibition in a complex plroteome

Kai Liu; Karunakaran A. Kalesh; Li Bing Ong; Shao Q. Yao

doi:10.1002/cbic.200800212

An improved mechanism-based cross-linker for multiplexed kinase detection and inhibition in a complex plroteome

Kai Liu
, Karunakaran A. Kalesh
, Li Bing Ong
, Shao Q. Yao

Research output: Contribution to journal › Article › peer-review

Abstract

Trapping the kinome: An improved mechanism-based cross-linker for kinase–substrate pairs has been demonstrated in multiplexed detection of kinase activities present in a complex proteome. The method was further extended to screen for inhibitors of multiple kinases in their native environments.

Original language	English
Pages (from-to)	1883-1888
Number of pages	6
Journal	ChemBioChem
Volume	9
Issue number	12
DOIs	https://doi.org/10.1002/cbic.200800212
Publication status	Published - 1 Aug 2008
Externally published	Yes

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title = "An improved mechanism-based cross-linker for multiplexed kinase detection and inhibition in a complex plroteome",

abstract = "Trapping the kinome: An improved mechanism-based cross-linker for kinase–substrate pairs has been demonstrated in multiplexed detection of kinase activities present in a complex proteome. The method was further extended to screen for inhibitors of multiple kinases in their native environments.",

author = "Kai Liu and Kalesh, \{Karunakaran A.\} and Ong, \{Li Bing\} and Yao, \{Shao Q.\}",

year = "2008",

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AU - Kalesh, Karunakaran A.

AU - Ong, Li Bing

AU - Yao, Shao Q.

PY - 2008/8/1

Y1 - 2008/8/1

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AB - Trapping the kinome: An improved mechanism-based cross-linker for kinase–substrate pairs has been demonstrated in multiplexed detection of kinase activities present in a complex proteome. The method was further extended to screen for inhibitors of multiple kinases in their native environments.

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An improved mechanism-based cross-linker for multiplexed kinase detection and inhibition in a complex plroteome

Abstract

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