An investigation of the mobility separation of some peptide and protein ions using a new hybrid quadrupole/travelling wave IMS/oa-ToF instrument

Steven D. Pringle, Kevin Giles, Jason L. Wildgoose, Jonathan P. Williams, Susan E. Slade, Konstantinos Thalassinos, Robert H. Bateman, Michael T. Bowers, James Scrivens

    Research output: Contribution to journalArticle

    544 Citations (Scopus)

    Abstract

    Ion mobility coupled with mass spectrometry has evolved into a powerful analytical technique for investigating the gas-phase structures of bio-molecules. Here we present the mobility separation of some peptide and protein ions using a new hybrid quadrupole/travelling wave ion mobility separator/orthogonal acceleration time-of-flight instrument. Comparison of the mobility data obtained from the relatively new travelling wave separation device with data obtained using various other mobility separators demonstrate that whilst the mobility characteristics are similar, the new hybrid instrument geometry provides mobility separation without compromising the base sensitivity of the mass spectrometer. This capability facilitates mobility studies of samples at analytically significant levels.

    Original languageEnglish
    Pages (from-to)1-12
    Number of pages12
    JournalInternational Journal of Mass Spectrometry
    Volume261
    Issue number1
    DOIs
    Publication statusPublished - 1 Mar 2007

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