An investigation of the mobility separation of some peptide and protein ions using a new hybrid quadrupole/travelling wave IMS/oa-ToF instrument

Steven D. Pringle; Kevin Giles; Jason L. Wildgoose; Jonathan P. Williams; Susan E. Slade; Konstantinos Thalassinos; Robert H. Bateman; Michael T. Bowers; James  Scrivens

doi:10.1016/j.ijms.2006.07.021

An investigation of the mobility separation of some peptide and protein ions using a new hybrid quadrupole/travelling wave IMS/oa-ToF instrument

Steven D. Pringle, Kevin Giles, Jason L. Wildgoose, Jonathan P. Williams, Susan E. Slade, Konstantinos Thalassinos, Robert H. Bateman, Michael T. Bowers, James Scrivens

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544 Citations (Scopus)

Abstract

Ion mobility coupled with mass spectrometry has evolved into a powerful analytical technique for investigating the gas-phase structures of bio-molecules. Here we present the mobility separation of some peptide and protein ions using a new hybrid quadrupole/travelling wave ion mobility separator/orthogonal acceleration time-of-flight instrument. Comparison of the mobility data obtained from the relatively new travelling wave separation device with data obtained using various other mobility separators demonstrate that whilst the mobility characteristics are similar, the new hybrid instrument geometry provides mobility separation without compromising the base sensitivity of the mass spectrometer. This capability facilitates mobility studies of samples at analytically significant levels.

Original language	English
Pages (from-to)	1-12
Number of pages	12
Journal	International Journal of Mass Spectrometry
Volume	261
Issue number	1
DOIs	https://doi.org/10.1016/j.ijms.2006.07.021
Publication status	Published - 1 Mar 2007

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Pringle, S. D., Giles, K., Wildgoose, J. L., Williams, J. P., Slade, S. E., Thalassinos, K., Bateman, R. H., Bowers, M. T., & Scrivens, J. (2007). An investigation of the mobility separation of some peptide and protein ions using a new hybrid quadrupole/travelling wave IMS/oa-ToF instrument. International Journal of Mass Spectrometry, 261(1), 1-12. https://doi.org/10.1016/j.ijms.2006.07.021

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abstract = "Ion mobility coupled with mass spectrometry has evolved into a powerful analytical technique for investigating the gas-phase structures of bio-molecules. Here we present the mobility separation of some peptide and protein ions using a new hybrid quadrupole/travelling wave ion mobility separator/orthogonal acceleration time-of-flight instrument. Comparison of the mobility data obtained from the relatively new travelling wave separation device with data obtained using various other mobility separators demonstrate that whilst the mobility characteristics are similar, the new hybrid instrument geometry provides mobility separation without compromising the base sensitivity of the mass spectrometer. This capability facilitates mobility studies of samples at analytically significant levels.",

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Pringle, SD, Giles, K, Wildgoose, JL, Williams, JP, Slade, SE, Thalassinos, K, Bateman, RH, Bowers, MT & Scrivens, J 2007, 'An investigation of the mobility separation of some peptide and protein ions using a new hybrid quadrupole/travelling wave IMS/oa-ToF instrument', International Journal of Mass Spectrometry, vol. 261, no. 1, pp. 1-12. https://doi.org/10.1016/j.ijms.2006.07.021

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T1 - An investigation of the mobility separation of some peptide and protein ions using a new hybrid quadrupole/travelling wave IMS/oa-ToF instrument

AU - Pringle, Steven D.

AU - Giles, Kevin

AU - Wildgoose, Jason L.

AU - Williams, Jonathan P.

AU - Slade, Susan E.

AU - Thalassinos, Konstantinos

AU - Bateman, Robert H.

AU - Bowers, Michael T.

AU - Scrivens, James

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AB - Ion mobility coupled with mass spectrometry has evolved into a powerful analytical technique for investigating the gas-phase structures of bio-molecules. Here we present the mobility separation of some peptide and protein ions using a new hybrid quadrupole/travelling wave ion mobility separator/orthogonal acceleration time-of-flight instrument. Comparison of the mobility data obtained from the relatively new travelling wave separation device with data obtained using various other mobility separators demonstrate that whilst the mobility characteristics are similar, the new hybrid instrument geometry provides mobility separation without compromising the base sensitivity of the mass spectrometer. This capability facilitates mobility studies of samples at analytically significant levels.

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JO - International Journal of Mass Spectrometry

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IS - 1

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An investigation of the mobility separation of some peptide and protein ions using a new hybrid quadrupole/travelling wave IMS/oa-ToF instrument

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