Analysis of air-, moisture- and solvent-sensitive chemical compounds by mass spectrometry using an inert atmospheric pressure solids analysis probe

Jackie A. Mosely, Peter Stokes, David Parker, Philip W. Dyer, Antonis M. Messinis

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

A novel method has been developed that enables chemical compounds to be transferred from an inert atmosphere glove box and into the atmospheric pressure ion source of a mass spectrometer whilst retaining a controlled chemical environment. This innovative method is simple and cheap to implement on some commercially available mass spectrometers. We have termed this approach inert atmospheric pressure solids analysis probe (iASAP) and demonstrate the benefit of this methodology for two air-/moisture-sensitive chemical compounds whose characterisation by mass spectrometry is now possible and easily achieved. The simplicity of the design means that moving between iASAP and standard ASAP is straightforward and quick, providing a highly flexible platform with rapid sample turnaround.

Original languageEnglish
Pages (from-to)74-80
Number of pages7
JournalEuropean Journal of Mass Spectrometry
Volume24
Issue number1
DOIs
Publication statusPublished - 1 Feb 2018

Bibliographical note

Publisher Copyright:
© 2017, © The Author(s) 2017.

Copyright:
Copyright 2019 Elsevier B.V., All rights reserved.

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