Abstract
| Original language | English |
|---|---|
| Pages (from-to) | - |
| Journal | Journal of Enzyme Inhibition and Medicinal Chemistry |
| DOIs | |
| Publication status | Published - 21 Oct 2016 |
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Antimicrobial metal-based thiophene derived compounds. / Yasmeen, Shakeela; Sumrra, S. H. (Sajjad); Akram, Muhammad Safwan; Chohan, Zahid H.
In: Journal of Enzyme Inhibition and Medicinal Chemistry, 21.10.2016, p. -.Research output: Contribution to journal › Article › Research › peer-review
TY - JOUR
T1 - Antimicrobial metal-based thiophene derived compounds
AU - Yasmeen, Shakeela
AU - Sumrra, S. H. (Sajjad)
AU - Akram, Muhammad Safwan
AU - Chohan, Zahid H.
PY - 2016/10/21
Y1 - 2016/10/21
N2 - A novel series of thiophene derived Schiff bases and their transition metal- [Co(II), Cu(II), Zn(II), Ni(II)] based compounds are reported. The Schiff bases act as tridentate ligands toward metal ions via azomethine-N, deprotonated-N of ammine substituents and S-atom of thienyl moiety. The synthesized ligands along with their metal complexes were screened for their in vitro antibacterial activity against six bacterial pathogens (Escherichia coli, Shigella flexneri, Pseudomonas aeruginosa, Salmonella typhi, Staphylococcus aureus and Bacillus subtilis) and for antifungal activity against six fungal pathogens (Trichophytonlongifusus, Candida albicans, Aspergillus flavus, Microsporum canis, Fusarium solani and Candida glabrata). The results of antimicrobial studies revealed the free ligands to possess potential activity which significantly increased upon chelation.
AB - A novel series of thiophene derived Schiff bases and their transition metal- [Co(II), Cu(II), Zn(II), Ni(II)] based compounds are reported. The Schiff bases act as tridentate ligands toward metal ions via azomethine-N, deprotonated-N of ammine substituents and S-atom of thienyl moiety. The synthesized ligands along with their metal complexes were screened for their in vitro antibacterial activity against six bacterial pathogens (Escherichia coli, Shigella flexneri, Pseudomonas aeruginosa, Salmonella typhi, Staphylococcus aureus and Bacillus subtilis) and for antifungal activity against six fungal pathogens (Trichophytonlongifusus, Candida albicans, Aspergillus flavus, Microsporum canis, Fusarium solani and Candida glabrata). The results of antimicrobial studies revealed the free ligands to possess potential activity which significantly increased upon chelation.
U2 - 10.1080/14756366.2016.1238363
DO - 10.1080/14756366.2016.1238363
M3 - Article
SP - -
JO - Journal of Enzyme Inhibition and Medicinal Chemistry
JF - Journal of Enzyme Inhibition and Medicinal Chemistry
SN - 1475-6374
ER -