Antimicrobial metal-based thiophene derived compounds

Shakeela Yasmeen; S. H. (Sajjad) Sumrra; Muhammad Safwan Akram; Zahid H. Chohan

doi:10.1080/14756366.2016.1238363

Antimicrobial metal-based thiophene derived compounds

Shakeela Yasmeen, S. H. (Sajjad) Sumrra, Muhammad Safwan Akram, Zahid H. Chohan

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Abstract

A novel series of thiophene derived Schiff bases and their transition metal- [Co(II), Cu(II), Zn(II), Ni(II)] based compounds are reported. The Schiff bases act as tridentate ligands toward metal ions via azomethine-N, deprotonated-N of ammine substituents and S-atom of thienyl moiety. The synthesized ligands along with their metal complexes were screened for their in vitro antibacterial activity against six bacterial pathogens (Escherichia coli, Shigella flexneri, Pseudomonas aeruginosa, Salmonella typhi, Staphylococcus aureus and Bacillus subtilis) and for antifungal activity against six fungal pathogens (Trichophytonlongifusus, Candida albicans, Aspergillus flavus, Microsporum canis, Fusarium solani and Candida glabrata). The results of antimicrobial studies revealed the free ligands to possess potential activity which significantly increased upon chelation.

Original language	English
Pages (from-to)	106=112
Journal	Journal of Enzyme Inhibition and Medicinal Chemistry
Volume	0
DOIs	https://doi.org/10.1080/14756366.2016.1238363
Publication status	Published - 21 Oct 2016

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10.1080/14756366.2016.1238363Licence: CC BY

PublicationFinal published version, 839 KBLicence: CC BY

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Safwan Akram
- Safwan.Akram@tees.ac.uk
- SHLS Life Sciences - Principal Lecturer (Enterprise & Business Engagement) for the NHC
- National Horizons Centre
Person: Academic

Cite this

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