Abstract
Introduction–Several taccalonolides with various bioactivities have been isolated from Tacca species but no studies to isolatetaccalonolides with anti-trypanosomal activity fromTacca leontopetaloideshave been reported.Objectives–To analyse extracts of the roots ofTacca leontopetaloides, purify the extracts by column chromatography and iden-tify isolated compounds by spectroscopic methods. The compounds and fractions will be tested for antitrypanosomal activityin vitroagainstTrypanosoma brucei brucei.Material and methods–Dried roots or tubers ofTacca leontopetaloides, chromatographic separation andspectroscopic identification.Results–A novel taccalonolide A propanoate and some known taccalonolides were isolated and their structures were determinedby NMR and mass spectrometryConclusion–Several taccalonolides were isolated fromTacca leontopetaloidesand were found to havein vitroantitrypanosomalactivity againstTrypanosoma brucei bruceiand EC50values for the isolated compounds were from 0.79μg/mL.
Original language | English |
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Pages (from-to) | 217-221 |
Journal | Phytochemical Analysis |
Volume | 27 |
Issue number | 3-4 |
DOIs | |
Publication status | Published - 17 Jun 2016 |