Antitrypanosomal activity of a novel taccalonolide from the tubers of Tacca leontopetaloides.

Vivian T. Dike, Burbwa Vihiior, Joel A. Bosha, Tung Mei Yin, Godwin Ebiloma, Harry P. De Koning, John O. Igoli, Alexander I. Gray

Research output: Contribution to journalArticlepeer-review


Introduction–Several taccalonolides with various bioactivities have been isolated from Tacca species but no studies to isolatetaccalonolides with anti-trypanosomal activity fromTacca leontopetaloideshave been reported.Objectives–To analyse extracts of the roots ofTacca leontopetaloides, purify the extracts by column chromatography and iden-tify isolated compounds by spectroscopic methods. The compounds and fractions will be tested for antitrypanosomal activityin vitroagainstTrypanosoma brucei brucei.Material and methods–Dried roots or tubers ofTacca leontopetaloides, chromatographic separation andspectroscopic identification.Results–A novel taccalonolide A propanoate and some known taccalonolides were isolated and their structures were determinedby NMR and mass spectrometryConclusion–Several taccalonolides were isolated fromTacca leontopetaloidesand were found to havein vitroantitrypanosomalactivity againstTrypanosoma brucei bruceiand EC50values for the isolated compounds were from 0.79μg/mL.
Original languageEnglish
Pages (from-to)217-221
JournalPhytochemical Analysis
Issue number3-4
Publication statusPublished - 17 Jun 2016


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