Assessing the potential of an induced-mutation strategy for avermectin overproducers

Hong Gao, Mei Liu, Ying Zhuo, Xianlong Zhou, Jintao Liu, Difei Chen, Wenquan Zhang, Zhongxuan Gou, Peng Shang, Lixin Zhang

    Research output: Contribution to journalArticlepeer-review


    Mutant libraries of avermectin-producing Streptomyces avermitilis strains were constructed by different mutagenesis strategies. A metric was applied to assess the mutation spectrum by calculating the distribution of average phenotypic distance of each population. The results showed for the first time that a microgravity environment could introduce larger phenotype distribution and diversity than UV and N-methyl-N-nitro-N-nitrosoguanidine (NTG) could.

    Original languageEnglish
    Pages (from-to)4583-6
    Number of pages4
    JournalApplied and Environmental Microbiology
    Issue number13
    Publication statusPublished - Jul 2010


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