Assessing the potential of an induced-mutation strategy for avermectin overproducers

Hong Gao; Mei Liu; Ying Zhuo; Xianlong Zhou; Jintao Liu; Difei Chen; Wenquan Zhang; Zhongxuan Gou; Peng Shang; Lixin Zhang

doi:10.1128/AEM.01682-09

Assessing the potential of an induced-mutation strategy for avermectin overproducers

Hong Gao
, Mei Liu
, Ying Zhuo
, Xianlong Zhou
, Jintao Liu
, Difei Chen
, Wenquan Zhang
, Zhongxuan Gou
, Peng Shang
, Lixin Zhang

Research output: Contribution to journal › Article › peer-review

Abstract

Mutant libraries of avermectin-producing Streptomyces avermitilis strains were constructed by different mutagenesis strategies. A metric was applied to assess the mutation spectrum by calculating the distribution of average phenotypic distance of each population. The results showed for the first time that a microgravity environment could introduce larger phenotype distribution and diversity than UV and N-methyl-N-nitro-N-nitrosoguanidine (NTG) could.

Original language	English
Pages (from-to)	4583-6
Number of pages	4
Journal	Applied and Environmental Microbiology
Volume	76
Issue number	13
DOIs	https://doi.org/10.1128/AEM.01682-09
Publication status	Published - Jul 2010

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10.1128/AEM.01682-09

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title = "Assessing the potential of an induced-mutation strategy for avermectin overproducers",

abstract = "Mutant libraries of avermectin-producing Streptomyces avermitilis strains were constructed by different mutagenesis strategies. A metric was applied to assess the mutation spectrum by calculating the distribution of average phenotypic distance of each population. The results showed for the first time that a microgravity environment could introduce larger phenotype distribution and diversity than UV and N-methyl-N-nitro-N-nitrosoguanidine (NTG) could.",

author = "Hong Gao and Mei Liu and Ying Zhuo and Xianlong Zhou and Jintao Liu and Difei Chen and Wenquan Zhang and Zhongxuan Gou and Peng Shang and Lixin Zhang",

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AU - Gao, Hong

AU - Liu, Mei

AU - Zhuo, Ying

AU - Zhou, Xianlong

AU - Liu, Jintao

AU - Chen, Difei

AU - Zhang, Wenquan

AU - Gou, Zhongxuan

AU - Shang, Peng

AU - Zhang, Lixin

PY - 2010/7

Y1 - 2010/7

N2 - Mutant libraries of avermectin-producing Streptomyces avermitilis strains were constructed by different mutagenesis strategies. A metric was applied to assess the mutation spectrum by calculating the distribution of average phenotypic distance of each population. The results showed for the first time that a microgravity environment could introduce larger phenotype distribution and diversity than UV and N-methyl-N-nitro-N-nitrosoguanidine (NTG) could.

AB - Mutant libraries of avermectin-producing Streptomyces avermitilis strains were constructed by different mutagenesis strategies. A metric was applied to assess the mutation spectrum by calculating the distribution of average phenotypic distance of each population. The results showed for the first time that a microgravity environment could introduce larger phenotype distribution and diversity than UV and N-methyl-N-nitro-N-nitrosoguanidine (NTG) could.

U2 - 10.1128/AEM.01682-09

DO - 10.1128/AEM.01682-09

M3 - Article

C2 - 20453119

SN - 0099-2240

VL - 76

SP - 4583

EP - 4586

JO - Applied and Environmental Microbiology

JF - Applied and Environmental Microbiology

IS - 13

ER -

Assessing the potential of an induced-mutation strategy for avermectin overproducers

Abstract

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