Bioactive Bacterial Cellulose Sulfate Electrospun Nanofibers for Tissue Engineering Applications

Vivekanandan Palaninathan, Sreejith Raveendran, Ankit Rochani, Neha Chauhan, Yasushi Sakamoto, Tomofomi Ukai, Toru Maekawa, Sakthi Kumar

Research output: Contribution to journalArticlepeer-review


Cellulosic materials have been of tremendous importance to mankind since its discovery due to its superior properties and its abundance in nature. Recently, an increase in demand for alternate green materials has rekindled the interest for cellulosic materials. Here, bacterial cellulose has been functionalized with sulfate groups through acetosulfation to gain solubility in aqueous media, which provides access to several applications. The cell viability, antioxidant, and hemocompatibility assays have verified the biocompatible and antioxidant characteristics of bacterial cellulose sulfate (BCS) in both in vitro and ex vivo conditions. Further, novel BCS/polyvinyl alcohol nanofibers were fabricated by simple electrospinning route to engineer ultrafine nanoscale fibers. The biological evaluation of BCS/polyvinyl alcohol nanofiber scaffolds was done using L929 mouse fibroblast cells, which confirmed that these nanofibers are excellent matrices for cell adhesion and proliferation.

Original languageEnglish
Pages (from-to)1634-1645
JournalJournal of Tissue Engineering and Regenerative Medicine
Issue number7
Early online date28 Apr 2018
Publication statusPublished - 18 May 2018


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