Bioassay-guided isolation of active principles from Nigerian medicinal plants identifies new trypanocides with low toxicity and no cross-resistance to diamidines and arsenicals

Godwin Ebiloma; John  OgbajiIgoli; Evangelos  Katsoulis; Anne-Marie  Donachie; Anthonius Anayochukwu  Eze; Alexander Ian  Gray; Harry P. De Koning

doi:10.1016/j.jep.2017.03.028

Bioassay-guided isolation of active principles from Nigerian medicinal plants identifies new trypanocides with low toxicity and no cross-resistance to diamidines and arsenicals

Godwin Ebiloma, John OgbajiIgoli, Evangelos Katsoulis, Anne-Marie Donachie, Anthonius Anayochukwu Eze, Alexander Ian Gray, Harry P. De Koning

Research output: Contribution to journal › Article › peer-review

Abstract

Ethnopharmacological relevance
Leaves from the plant species studied herein are traditionally used in northern Nigeria against various protozoan infections. However, none of these herbal preparations have been standardized, nor have their toxicity to mammalian cells been investigated. In search of improved and non-toxic active antiprotozoal principles that are not cross-resistant with current anti-parasitics, we here report the results of the in vitro screening of extracts from seven selected medicinal plant species (Centrosema pubescens, Moringa oleifera, Tridax procumbens, Polyalthia longifolia, Newbouldia laevis, Eucalyptus maculate, Jathropha tanjorensis), used traditionally to treat kinetoplastid infections in Nigeria, and the isolation of their bioactive principles.

Original language	English
Pages (from-to)	256-264
Journal	Journal of Ethnopharmacology
Volume	202
DOIs	https://doi.org/10.1016/j.jep.2017.03.028
Publication status	Published - 18 Apr 2017

Access to Document

10.1016/j.jep.2017.03.028

Cite this

Ebiloma, G., OgbajiIgoli, J., Katsoulis, E., Donachie, A.-M., Eze, A. A., Gray, A. I., & De Koning, H. P. (2017). Bioassay-guided isolation of active principles from Nigerian medicinal plants identifies new trypanocides with low toxicity and no cross-resistance to diamidines and arsenicals. Journal of Ethnopharmacology, 202, 256-264. https://doi.org/10.1016/j.jep.2017.03.028

@article{8564f93b9c1b480b86f28e02fce3be22,

title = "Bioassay-guided isolation of active principles from Nigerian medicinal plants identifies new trypanocides with low toxicity and no cross-resistance to diamidines and arsenicals",

abstract = "Ethnopharmacological relevanceLeaves from the plant species studied herein are traditionally used in northern Nigeria against various protozoan infections. However, none of these herbal preparations have been standardized, nor have their toxicity to mammalian cells been investigated. In search of improved and non-toxic active antiprotozoal principles that are not cross-resistant with current anti-parasitics, we here report the results of the in vitro screening of extracts from seven selected medicinal plant species (Centrosema pubescens, Moringa oleifera, Tridax procumbens, Polyalthia longifolia, Newbouldia laevis, Eucalyptus maculate, Jathropha tanjorensis), used traditionally to treat kinetoplastid infections in Nigeria, and the isolation of their bioactive principles.",

author = "Godwin Ebiloma and John OgbajiIgoli and Evangelos Katsoulis and Anne-Marie Donachie and Eze, {Anthonius Anayochukwu} and Gray, {Alexander Ian} and {De Koning}, {Harry P.}",

year = "2017",

month = apr,

day = "18",

doi = "10.1016/j.jep.2017.03.028",

language = "English",

volume = "202",

pages = "256--264",

journal = "Journal of Ethnopharmacology",

issn = "0378-8741",

publisher = "Elsevier",

}

Ebiloma, G, OgbajiIgoli, J, Katsoulis, E, Donachie, A-M, Eze, AA, Gray, AI & De Koning, HP 2017, 'Bioassay-guided isolation of active principles from Nigerian medicinal plants identifies new trypanocides with low toxicity and no cross-resistance to diamidines and arsenicals', Journal of Ethnopharmacology, vol. 202, pp. 256-264. https://doi.org/10.1016/j.jep.2017.03.028

Bioassay-guided isolation of active principles from Nigerian medicinal plants identifies new trypanocides with low toxicity and no cross-resistance to diamidines and arsenicals. / Ebiloma, Godwin; OgbajiIgoli, John ; Katsoulis, Evangelos et al.
In: Journal of Ethnopharmacology, Vol. 202, 18.04.2017, p. 256-264.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Bioassay-guided isolation of active principles from Nigerian medicinal plants identifies new trypanocides with low toxicity and no cross-resistance to diamidines and arsenicals

AU - Ebiloma, Godwin

AU - OgbajiIgoli, John

AU - Katsoulis, Evangelos

AU - Donachie, Anne-Marie

AU - Eze, Anthonius Anayochukwu

AU - Gray, Alexander Ian

AU - De Koning, Harry P.

PY - 2017/4/18

Y1 - 2017/4/18

N2 - Ethnopharmacological relevanceLeaves from the plant species studied herein are traditionally used in northern Nigeria against various protozoan infections. However, none of these herbal preparations have been standardized, nor have their toxicity to mammalian cells been investigated. In search of improved and non-toxic active antiprotozoal principles that are not cross-resistant with current anti-parasitics, we here report the results of the in vitro screening of extracts from seven selected medicinal plant species (Centrosema pubescens, Moringa oleifera, Tridax procumbens, Polyalthia longifolia, Newbouldia laevis, Eucalyptus maculate, Jathropha tanjorensis), used traditionally to treat kinetoplastid infections in Nigeria, and the isolation of their bioactive principles.

AB - Ethnopharmacological relevanceLeaves from the plant species studied herein are traditionally used in northern Nigeria against various protozoan infections. However, none of these herbal preparations have been standardized, nor have their toxicity to mammalian cells been investigated. In search of improved and non-toxic active antiprotozoal principles that are not cross-resistant with current anti-parasitics, we here report the results of the in vitro screening of extracts from seven selected medicinal plant species (Centrosema pubescens, Moringa oleifera, Tridax procumbens, Polyalthia longifolia, Newbouldia laevis, Eucalyptus maculate, Jathropha tanjorensis), used traditionally to treat kinetoplastid infections in Nigeria, and the isolation of their bioactive principles.

U2 - 10.1016/j.jep.2017.03.028

DO - 10.1016/j.jep.2017.03.028

M3 - Article

SN - 0378-8741

VL - 202

SP - 256

EP - 264

JO - Journal of Ethnopharmacology

JF - Journal of Ethnopharmacology

ER -

Bioassay-guided isolation of active principles from Nigerian medicinal plants identifies new trypanocides with low toxicity and no cross-resistance to diamidines and arsenicals

Abstract

Access to Document

Fingerprint

Cite this