Biogenic Zinc Oxide Nanoparticles Synthesis Using Tabernaemontana divaricate Leaf Extract and Its Anticancer Activity against MCF-7 Breast Cancer Cell Lines

Rajeshwari Sivaraj, Pattanathu Rahman, P Rajiv, Rajendran Venckatesh

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    Abstract

    This investigation explains the biosynthesis and characterization of zinc oxide nanoparticles from an Indian medicinal plant by an eco -friendly method. The main objective of this study is to synthesize zinc oxide nanoparticles from Tabernaemontana divaricate leaves through a green chemistry approach. Highly stable, spherical zinc oxide nanoparticles were synthesized by using 50% concentration of Tabernaemontana leaf extract. Formation of zinc oxide nanoparticles have been characterized by X -ray diffraction (X RD), R aman spectroscopy and transmission electron microscopy (TEM) analysis. All the analysis reveals that zinc oxide nanoparticles were 36 ± 5 nm in size. Functional groups and chemical composition of zinc oxide were also confirmed . Tabernaemontana mediated zin c oxide nanoparticles showed effective cytotoxic effect against MCF -7 breast cancer cel l lines with an IC 50 value of 30.65 μg/ml/24 h by the MTT assay. These results clearly support the benefits of using biological method for synthesizing zinc oxide nanopa rticles with anticancer activities.
    Original languageEnglish
    DOIs
    Publication statusPublished - 15 Oct 2014
    EventInternational Conference on Advances in Agricultural, Biological & Environmental Sciences 2014 - Dubai, United Arab Emirates
    Duration: 15 Oct 201416 Oct 2014

    Conference

    ConferenceInternational Conference on Advances in Agricultural, Biological & Environmental Sciences 2014
    Abbreviated titleAABES-2014
    CountryUnited Arab Emirates
    CityDubai
    Period15/10/1416/10/14

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    Sivaraj, R., Rahman, P., Rajiv, P., & Venckatesh, R. (2014). Biogenic Zinc Oxide Nanoparticles Synthesis Using Tabernaemontana divaricate Leaf Extract and Its Anticancer Activity against MCF-7 Breast Cancer Cell Lines. Paper presented at International Conference on Advances in Agricultural, Biological & Environmental Sciences 2014, Dubai, United Arab Emirates. https://doi.org/10.15242/IICBE.C1014032