Brevianamides with antitubercular potential from a marine-derived isolate of Aspergillus versicolor

Fuhang Song, Xinru Liu, Hui Guo, Biao Ren, Caixia Chen, Andrew M Piggott, Ke Yu, Hong Gao, Qian Wang, Mei Liu, Xueting Liu, Huanqin Dai, Lixin Zhang, Robert J Capon

Research output: Contribution to journalArticleResearchpeer-review

Abstract

An Aspergillus versicolor isolated from sediment collected from the Bohai Sea, China, yielded the new dimeric diketopiperazine brevianamide S (1), together with three new monomeric cometabolites, brevianamides T (2), U (3), and V (4). Structures were determined by detailed spectroscopic analysis. Brevianamide S exhibited selective antibacterial activity against Bacille Calmette-Guérin (BCG), suggestive of a new mechanism of action that could inform the development of next-generation antitubercular drugs.

Original languageEnglish
Pages (from-to)4770-3
Number of pages4
JournalOrganic Letters
Volume14
Issue number18
DOIs
Publication statusPublished - 21 Sep 2012

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Aspergillus
spectroscopic analysis
China
sediments
drugs
Diketopiperazines
Antitubercular Agents
Spectroscopic analysis
Oceans and Seas
Sediments
brevianamide S

Cite this

Song, F., Liu, X., Guo, H., Ren, B., Chen, C., Piggott, A. M., ... Capon, R. J. (2012). Brevianamides with antitubercular potential from a marine-derived isolate of Aspergillus versicolor. Organic Letters, 14(18), 4770-3. https://doi.org/10.1021/ol302051x
Song, Fuhang ; Liu, Xinru ; Guo, Hui ; Ren, Biao ; Chen, Caixia ; Piggott, Andrew M ; Yu, Ke ; Gao, Hong ; Wang, Qian ; Liu, Mei ; Liu, Xueting ; Dai, Huanqin ; Zhang, Lixin ; Capon, Robert J. / Brevianamides with antitubercular potential from a marine-derived isolate of Aspergillus versicolor. In: Organic Letters. 2012 ; Vol. 14, No. 18. pp. 4770-3.
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abstract = "An Aspergillus versicolor isolated from sediment collected from the Bohai Sea, China, yielded the new dimeric diketopiperazine brevianamide S (1), together with three new monomeric cometabolites, brevianamides T (2), U (3), and V (4). Structures were determined by detailed spectroscopic analysis. Brevianamide S exhibited selective antibacterial activity against Bacille Calmette-Gu{\'e}rin (BCG), suggestive of a new mechanism of action that could inform the development of next-generation antitubercular drugs.",
author = "Fuhang Song and Xinru Liu and Hui Guo and Biao Ren and Caixia Chen and Piggott, {Andrew M} and Ke Yu and Hong Gao and Qian Wang and Mei Liu and Xueting Liu and Huanqin Dai and Lixin Zhang and Capon, {Robert J}",
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Song, F, Liu, X, Guo, H, Ren, B, Chen, C, Piggott, AM, Yu, K, Gao, H, Wang, Q, Liu, M, Liu, X, Dai, H, Zhang, L & Capon, RJ 2012, 'Brevianamides with antitubercular potential from a marine-derived isolate of Aspergillus versicolor', Organic Letters, vol. 14, no. 18, pp. 4770-3. https://doi.org/10.1021/ol302051x

Brevianamides with antitubercular potential from a marine-derived isolate of Aspergillus versicolor. / Song, Fuhang; Liu, Xinru; Guo, Hui; Ren, Biao; Chen, Caixia; Piggott, Andrew M; Yu, Ke; Gao, Hong; Wang, Qian; Liu, Mei; Liu, Xueting; Dai, Huanqin; Zhang, Lixin; Capon, Robert J.

In: Organic Letters, Vol. 14, No. 18, 21.09.2012, p. 4770-3.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Brevianamides with antitubercular potential from a marine-derived isolate of Aspergillus versicolor

AU - Song, Fuhang

AU - Liu, Xinru

AU - Guo, Hui

AU - Ren, Biao

AU - Chen, Caixia

AU - Piggott, Andrew M

AU - Yu, Ke

AU - Gao, Hong

AU - Wang, Qian

AU - Liu, Mei

AU - Liu, Xueting

AU - Dai, Huanqin

AU - Zhang, Lixin

AU - Capon, Robert J

PY - 2012/9/21

Y1 - 2012/9/21

N2 - An Aspergillus versicolor isolated from sediment collected from the Bohai Sea, China, yielded the new dimeric diketopiperazine brevianamide S (1), together with three new monomeric cometabolites, brevianamides T (2), U (3), and V (4). Structures were determined by detailed spectroscopic analysis. Brevianamide S exhibited selective antibacterial activity against Bacille Calmette-Guérin (BCG), suggestive of a new mechanism of action that could inform the development of next-generation antitubercular drugs.

AB - An Aspergillus versicolor isolated from sediment collected from the Bohai Sea, China, yielded the new dimeric diketopiperazine brevianamide S (1), together with three new monomeric cometabolites, brevianamides T (2), U (3), and V (4). Structures were determined by detailed spectroscopic analysis. Brevianamide S exhibited selective antibacterial activity against Bacille Calmette-Guérin (BCG), suggestive of a new mechanism of action that could inform the development of next-generation antitubercular drugs.

U2 - 10.1021/ol302051x

DO - 10.1021/ol302051x

M3 - Article

VL - 14

SP - 4770

EP - 4773

JO - Organic Letters

JF - Organic Letters

SN - 1523-7060

IS - 18

ER -