Brevianamides with antitubercular potential from a marine-derived isolate of Aspergillus versicolor

Fuhang Song; Xinru Liu; Hui Guo; Biao Ren; Caixia Chen; Andrew M Piggott; Ke Yu; Hong Gao; Qian Wang; Mei Liu; Xueting Liu; Huanqin Dai; Lixin Zhang; Robert J Capon

doi:10.1021/ol302051x

Brevianamides with antitubercular potential from a marine-derived isolate of Aspergillus versicolor

Fuhang Song, Xinru Liu, Hui Guo, Biao Ren, Caixia Chen, Andrew M Piggott, Ke Yu, Hong Gao, Qian Wang, Mei Liu, Xueting Liu, Huanqin Dai, Lixin Zhang, Robert J Capon

Research output: Contribution to journal › Article › peer-review

Abstract

An Aspergillus versicolor isolated from sediment collected from the Bohai Sea, China, yielded the new dimeric diketopiperazine brevianamide S (1), together with three new monomeric cometabolites, brevianamides T (2), U (3), and V (4). Structures were determined by detailed spectroscopic analysis. Brevianamide S exhibited selective antibacterial activity against Bacille Calmette-Guérin (BCG), suggestive of a new mechanism of action that could inform the development of next-generation antitubercular drugs.

Original language	English
Pages (from-to)	4770-3
Number of pages	4
Journal	Organic Letters
Volume	14
Issue number	18
DOIs	https://doi.org/10.1021/ol302051x
Publication status	Published - 21 Sept 2012

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title = "Brevianamides with antitubercular potential from a marine-derived isolate of Aspergillus versicolor",

abstract = "An Aspergillus versicolor isolated from sediment collected from the Bohai Sea, China, yielded the new dimeric diketopiperazine brevianamide S (1), together with three new monomeric cometabolites, brevianamides T (2), U (3), and V (4). Structures were determined by detailed spectroscopic analysis. Brevianamide S exhibited selective antibacterial activity against Bacille Calmette-Gu{\'e}rin (BCG), suggestive of a new mechanism of action that could inform the development of next-generation antitubercular drugs.",

author = "Fuhang Song and Xinru Liu and Hui Guo and Biao Ren and Caixia Chen and Piggott, {Andrew M} and Ke Yu and Hong Gao and Qian Wang and Mei Liu and Xueting Liu and Huanqin Dai and Lixin Zhang and Capon, {Robert J}",

year = "2012",

month = sep,

day = "21",

doi = "10.1021/ol302051x",

language = "English",

volume = "14",

pages = "4770--3",

journal = "Organic Letters",

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T1 - Brevianamides with antitubercular potential from a marine-derived isolate of Aspergillus versicolor

AU - Song, Fuhang

AU - Liu, Xinru

AU - Guo, Hui

AU - Ren, Biao

AU - Chen, Caixia

AU - Piggott, Andrew M

AU - Yu, Ke

AU - Gao, Hong

AU - Wang, Qian

AU - Liu, Mei

AU - Liu, Xueting

AU - Dai, Huanqin

AU - Zhang, Lixin

AU - Capon, Robert J

PY - 2012/9/21

Y1 - 2012/9/21

N2 - An Aspergillus versicolor isolated from sediment collected from the Bohai Sea, China, yielded the new dimeric diketopiperazine brevianamide S (1), together with three new monomeric cometabolites, brevianamides T (2), U (3), and V (4). Structures were determined by detailed spectroscopic analysis. Brevianamide S exhibited selective antibacterial activity against Bacille Calmette-Guérin (BCG), suggestive of a new mechanism of action that could inform the development of next-generation antitubercular drugs.

AB - An Aspergillus versicolor isolated from sediment collected from the Bohai Sea, China, yielded the new dimeric diketopiperazine brevianamide S (1), together with three new monomeric cometabolites, brevianamides T (2), U (3), and V (4). Structures were determined by detailed spectroscopic analysis. Brevianamide S exhibited selective antibacterial activity against Bacille Calmette-Guérin (BCG), suggestive of a new mechanism of action that could inform the development of next-generation antitubercular drugs.

U2 - 10.1021/ol302051x

DO - 10.1021/ol302051x

M3 - Article

C2 - 22963079

SN - 1523-7060

VL - 14

SP - 4770

EP - 4773

JO - Organic Letters

JF - Organic Letters

IS - 18

ER -

Brevianamides with antitubercular potential from a marine-derived isolate of Aspergillus versicolor

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