Brevianamides with antitubercular potential from a marine-derived isolate of Aspergillus versicolor

Fuhang Song, Xinru Liu, Hui Guo, Biao Ren, Caixia Chen, Andrew M Piggott, Ke Yu, Hong Gao, Qian Wang, Mei Liu, Xueting Liu, Huanqin Dai, Lixin Zhang, Robert J Capon

    Research output: Contribution to journalArticlepeer-review

    Abstract

    An Aspergillus versicolor isolated from sediment collected from the Bohai Sea, China, yielded the new dimeric diketopiperazine brevianamide S (1), together with three new monomeric cometabolites, brevianamides T (2), U (3), and V (4). Structures were determined by detailed spectroscopic analysis. Brevianamide S exhibited selective antibacterial activity against Bacille Calmette-Guérin (BCG), suggestive of a new mechanism of action that could inform the development of next-generation antitubercular drugs.

    Original languageEnglish
    Pages (from-to)4770-3
    Number of pages4
    JournalOrganic Letters
    Volume14
    Issue number18
    DOIs
    Publication statusPublished - 21 Sep 2012

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