Catalytic Wittig and Mitsunobu Reactions

Christopher O'Brien

    Research output: PatentResearch

    Abstract

    A catalytic Wittig method utilizing a phosphine including the steps of providing a phosphine oxide precatalyst and reducing the phosphine oxide precatalyst to produce the phosphine; forming a phosphonium ylide precursor from the phosphine and a reactant; generating a phosphonium ylide from the phosphonium ylide precursor; reacting the phosphonium ylide precursor with the aldehyde, ketone, or ester to form the olefin and the phosphine oxide which then reenters the cycle. The invention is also directed to a Mitsunobu reaction catalytic in phosphine.
    Original languageEnglish
    Publication statusPublished - 2 Dec 2014

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    phosphine
    Oxides
    Alkenes
    Patents and inventions
    Ketones
    Aldehydes

    Cite this

    O'Brien, Christopher (Author). / Catalytic Wittig and Mitsunobu Reactions.
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    Catalytic Wittig and Mitsunobu Reactions. / O'Brien, Christopher.

    Research output: PatentResearch

    TY - PAT

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    PY - 2014/12/2

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    N2 - A catalytic Wittig method utilizing a phosphine including the steps of providing a phosphine oxide precatalyst and reducing the phosphine oxide precatalyst to produce the phosphine; forming a phosphonium ylide precursor from the phosphine and a reactant; generating a phosphonium ylide from the phosphonium ylide precursor; reacting the phosphonium ylide precursor with the aldehyde, ketone, or ester to form the olefin and the phosphine oxide which then reenters the cycle. The invention is also directed to a Mitsunobu reaction catalytic in phosphine.

    AB - A catalytic Wittig method utilizing a phosphine including the steps of providing a phosphine oxide precatalyst and reducing the phosphine oxide precatalyst to produce the phosphine; forming a phosphonium ylide precursor from the phosphine and a reactant; generating a phosphonium ylide from the phosphonium ylide precursor; reacting the phosphonium ylide precursor with the aldehyde, ketone, or ester to form the olefin and the phosphine oxide which then reenters the cycle. The invention is also directed to a Mitsunobu reaction catalytic in phosphine.

    M3 - Patent

    ER -