TY - JOUR
T1 - Cellular pathology within the anterior cingulate cortex of patients with late-life depression
T2 - A morphometric study
AU - Khundakar, Ahmad
AU - Morris, Christopher Miles
AU - Oakley, Arthur Ernest
AU - Thomas, Alan Jeffrey
PY - 2011/11/30
Y1 - 2011/11/30
N2 - Previous imaging and morphometric studies have identified volumetric and cellular abnormalities in prefrontal areas in late-life depression. This study aimed to examine cellular morphology using stereological methodology in the supragenual region of the anterior cingulate cortex in late-life depressed patients compared with age-matched controls. Post-mortem tissue was acquired from nine patients with depression and 11 control patients and analyzed using the optical disector and nucleator methods. No changes were found in glial, non-pyramidal and pyramidal cell density, or in non-pyramidal or pyramidal cell volume within individual layers (2-5) or the supragenual anterior cortex as a whole. This study, therefore, does not provide further evidence for cellular abnormalities in late-life depression.
AB - Previous imaging and morphometric studies have identified volumetric and cellular abnormalities in prefrontal areas in late-life depression. This study aimed to examine cellular morphology using stereological methodology in the supragenual region of the anterior cingulate cortex in late-life depressed patients compared with age-matched controls. Post-mortem tissue was acquired from nine patients with depression and 11 control patients and analyzed using the optical disector and nucleator methods. No changes were found in glial, non-pyramidal and pyramidal cell density, or in non-pyramidal or pyramidal cell volume within individual layers (2-5) or the supragenual anterior cortex as a whole. This study, therefore, does not provide further evidence for cellular abnormalities in late-life depression.
UR - http://www.scopus.com/inward/record.url?scp=80054088615&partnerID=8YFLogxK
U2 - 10.1016/j.pscychresns.2011.04.008
DO - 10.1016/j.pscychresns.2011.04.008
M3 - Article
C2 - 21924875
AN - SCOPUS:80054088615
SN - 0925-4927
VL - 194
SP - 184
EP - 189
JO - Psychiatry Research - Neuroimaging
JF - Psychiatry Research - Neuroimaging
IS - 2
ER -