Cellular pathology within the anterior cingulate cortex of patients with late-life depression: A morphometric study

Ahmad Khundakar, Christopher Miles Morris, Arthur Ernest Oakley, Alan Jeffrey Thomas

    Research output: Contribution to journalArticlepeer-review

    17 Citations (Scopus)

    Abstract

    Previous imaging and morphometric studies have identified volumetric and cellular abnormalities in prefrontal areas in late-life depression. This study aimed to examine cellular morphology using stereological methodology in the supragenual region of the anterior cingulate cortex in late-life depressed patients compared with age-matched controls. Post-mortem tissue was acquired from nine patients with depression and 11 control patients and analyzed using the optical disector and nucleator methods. No changes were found in glial, non-pyramidal and pyramidal cell density, or in non-pyramidal or pyramidal cell volume within individual layers (2-5) or the supragenual anterior cortex as a whole. This study, therefore, does not provide further evidence for cellular abnormalities in late-life depression.

    Original languageEnglish
    Pages (from-to)184-189
    Number of pages6
    JournalPsychiatry Research - Neuroimaging
    Volume194
    Issue number2
    DOIs
    Publication statusPublished - 30 Nov 2011

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