Cerebral oxygenation and cardiorespiratory stability following liberal transfusion in preterm neonates

Maria Saito-Benz, Clint Gray, Yu-Chieh Tzeng, Greg Atkinson, Mary J. Berry

Research output: Contribution to journalComment/debate

Abstract

INTRODUCTION
Regional oxygenation (rSO2) by near-infrared spectroscopy (NIRS) has the potential to informvital organ oxygenation and has been advocated
as a potential clinical adjunct to the current haemoglobin-based neonatal transfusion guidelines (1). Researchers have demonstrated that transfusion of red blood cells (RBCs) for anaemia of prematurity leads to increases in rSO2 and/or decreases in fractional tissue oxygen extraction (FTOE) in the brain, kidney, gut and muscle up to 24 hours after transfusion (2–4).

However, the effects of transfusion on regional oxygenation beyond the initial 24 hours after transfusion are currently not known. We aimed to determine whether liberal transfusion resulted in a sustained increase in cerebral rSO2(crSO2) or cardiorespiratory stability in anaemic preterm infants up to five days.
Original languageEnglish
Article numberAPA14631
Number of pages3
JournalActa Paediatrica
Volume108
Issue number3
Early online date20 Nov 2018
DOIs
Publication statusE-pub ahead of print - 20 Nov 2018

Fingerprint

Erythrocyte Transfusion
Near-Infrared Spectroscopy
Premature Infants
Anemia
Hemoglobins
Research Personnel
Newborn Infant
Guidelines
Oxygen
Kidney
Muscles
Brain

Cite this

Saito-Benz, Maria ; Gray, Clint ; Tzeng, Yu-Chieh ; Atkinson, Greg ; Berry, Mary J. / Cerebral oxygenation and cardiorespiratory stability following liberal transfusion in preterm neonates. In: Acta Paediatrica. 2018 ; Vol. 108, No. 3.
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Cerebral oxygenation and cardiorespiratory stability following liberal transfusion in preterm neonates. / Saito-Benz, Maria; Gray, Clint; Tzeng, Yu-Chieh; Atkinson, Greg; Berry, Mary J.

In: Acta Paediatrica, Vol. 108, No. 3, APA14631, 20.11.2018.

Research output: Contribution to journalComment/debate

TY - JOUR

T1 - Cerebral oxygenation and cardiorespiratory stability following liberal transfusion in preterm neonates

AU - Saito-Benz, Maria

AU - Gray, Clint

AU - Tzeng, Yu-Chieh

AU - Atkinson, Greg

AU - Berry, Mary J.

PY - 2018/11/20

Y1 - 2018/11/20

N2 - INTRODUCTIONRegional oxygenation (rSO2) by near-infrared spectroscopy (NIRS) has the potential to informvital organ oxygenation and has been advocatedas a potential clinical adjunct to the current haemoglobin-based neonatal transfusion guidelines (1). Researchers have demonstrated that transfusion of red blood cells (RBCs) for anaemia of prematurity leads to increases in rSO2 and/or decreases in fractional tissue oxygen extraction (FTOE) in the brain, kidney, gut and muscle up to 24 hours after transfusion (2–4).However, the effects of transfusion on regional oxygenation beyond the initial 24 hours after transfusion are currently not known. We aimed to determine whether liberal transfusion resulted in a sustained increase in cerebral rSO2(crSO2) or cardiorespiratory stability in anaemic preterm infants up to five days.

AB - INTRODUCTIONRegional oxygenation (rSO2) by near-infrared spectroscopy (NIRS) has the potential to informvital organ oxygenation and has been advocatedas a potential clinical adjunct to the current haemoglobin-based neonatal transfusion guidelines (1). Researchers have demonstrated that transfusion of red blood cells (RBCs) for anaemia of prematurity leads to increases in rSO2 and/or decreases in fractional tissue oxygen extraction (FTOE) in the brain, kidney, gut and muscle up to 24 hours after transfusion (2–4).However, the effects of transfusion on regional oxygenation beyond the initial 24 hours after transfusion are currently not known. We aimed to determine whether liberal transfusion resulted in a sustained increase in cerebral rSO2(crSO2) or cardiorespiratory stability in anaemic preterm infants up to five days.

U2 - 10.1111/apa.14631

DO - 10.1111/apa.14631

M3 - Comment/debate

VL - 108

JO - Acta Paediatrica, International Journal of Paediatrics

JF - Acta Paediatrica, International Journal of Paediatrics

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