Abstract
INTRODUCTION
Regional oxygenation (rSO2) by near-infrared spectroscopy (NIRS) has the potential to informvital organ oxygenation and has been advocated
as a potential clinical adjunct to the current haemoglobin-based neonatal transfusion guidelines (1). Researchers have demonstrated that transfusion of red blood cells (RBCs) for anaemia of prematurity leads to increases in rSO2 and/or decreases in fractional tissue oxygen extraction (FTOE) in the brain, kidney, gut and muscle up to 24 hours after transfusion (2–4).
However, the effects of transfusion on regional oxygenation beyond the initial 24 hours after transfusion are currently not known. We aimed to determine whether liberal transfusion resulted in a sustained increase in cerebral rSO2(crSO2) or cardiorespiratory stability in anaemic preterm infants up to five days.
Regional oxygenation (rSO2) by near-infrared spectroscopy (NIRS) has the potential to informvital organ oxygenation and has been advocated
as a potential clinical adjunct to the current haemoglobin-based neonatal transfusion guidelines (1). Researchers have demonstrated that transfusion of red blood cells (RBCs) for anaemia of prematurity leads to increases in rSO2 and/or decreases in fractional tissue oxygen extraction (FTOE) in the brain, kidney, gut and muscle up to 24 hours after transfusion (2–4).
However, the effects of transfusion on regional oxygenation beyond the initial 24 hours after transfusion are currently not known. We aimed to determine whether liberal transfusion resulted in a sustained increase in cerebral rSO2(crSO2) or cardiorespiratory stability in anaemic preterm infants up to five days.
| Original language | English |
|---|---|
| Article number | APA14631 |
| Number of pages | 3 |
| Journal | Acta Paediatrica |
| Volume | 108 |
| Issue number | 3 |
| Early online date | 20 Nov 2018 |
| DOIs |
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| Publication status | E-pub ahead of print - 20 Nov 2018 |