Cerebral oxygenation and cardiorespiratory stability following liberal transfusion in preterm neonates

Maria Saito-Benz, Clint Gray, Yu-Chieh Tzeng, Greg Atkinson, Mary J. Berry

    Research output: Contribution to journalComment/debate

    Abstract

    INTRODUCTION
    Regional oxygenation (rSO2) by near-infrared spectroscopy (NIRS) has the potential to informvital organ oxygenation and has been advocated
    as a potential clinical adjunct to the current haemoglobin-based neonatal transfusion guidelines (1). Researchers have demonstrated that transfusion of red blood cells (RBCs) for anaemia of prematurity leads to increases in rSO2 and/or decreases in fractional tissue oxygen extraction (FTOE) in the brain, kidney, gut and muscle up to 24 hours after transfusion (2–4).

    However, the effects of transfusion on regional oxygenation beyond the initial 24 hours after transfusion are currently not known. We aimed to determine whether liberal transfusion resulted in a sustained increase in cerebral rSO2(crSO2) or cardiorespiratory stability in anaemic preterm infants up to five days.
    Original languageEnglish
    Article numberAPA14631
    Number of pages3
    JournalActa Paediatrica
    Volume108
    Issue number3
    Early online date20 Nov 2018
    DOIs
    Publication statusE-pub ahead of print - 20 Nov 2018

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