CHARACTERISATION OF SPONTANEOUS CONTRACTILITY OF THE MUCOSAL LAYER OF GUINEA PIG BLADDER: COMPARISON WITH THE DETRUSOR AND INTACT BLADDER LAYERS

N. Kushida; J. Young; T. Hague; K. Aikawa; O. Yamaguchi; C. Fry

doi:10.1002/nau.22287

CHARACTERISATION OF SPONTANEOUS CONTRACTILITY OF THE MUCOSAL LAYER OF GUINEA PIG BLADDER: COMPARISON WITH THE DETRUSOR AND INTACT BLADDER LAYERS

N. Kushida, J. Young, T. Hague, K. Aikawa, O. Yamaguchi, C. Fry

Research output: Contribution to journal › Article › peer-review

Abstract

The urothelium is more than a passive barrier to urine and bacteria; it actively produces bioactive compounds in response tostimuli. Moreover, recent reports [1] show that the mucosal layer exhibits phasic spontaneous contractions; not unlike detrusor or whole bladder wall (‘intact’) preparations. The purpose of this study was to investigate the pharmacology of mucosal layer contractions, testing the hypothesis that spontaneous contractions (SpC) and slow, tonic contraction are of different origin.

Original language	English
Article number	232
Pages (from-to)	1025-1026
Number of pages	2
Journal	Neurourology and Urodynamics
Volume	31
Issue number	6
DOIs	https://doi.org/10.1002/nau.22287
Publication status	Published - 1 Aug 2012
Event	42nd Annual Meeting of the International-Continence-Society - Beijing, China Duration: 15 Oct 2012 → 19 Oct 2012

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title = "CHARACTERISATION OF SPONTANEOUS CONTRACTILITY OF THE MUCOSAL LAYER OF GUINEA PIG BLADDER: COMPARISON WITH THE DETRUSOR AND INTACT BLADDER LAYERS",

abstract = "The urothelium is more than a passive barrier to urine and bacteria; it actively produces bioactive compounds in response tostimuli. Moreover, recent reports [1] show that the mucosal layer exhibits phasic spontaneous contractions; not unlike detrusor or whole bladder wall ({\textquoteleft}intact{\textquoteright}) preparations. The purpose of this study was to investigate the pharmacology of mucosal layer contractions, testing the hypothesis that spontaneous contractions (SpC) and slow, tonic contraction are of different origin.",

author = "N. Kushida and J. Young and T. Hague and K. Aikawa and O. Yamaguchi and C. Fry",

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AU - Young, J.

AU - Hague, T.

AU - Aikawa, K.

AU - Yamaguchi, O.

AU - Fry, C.

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AB - The urothelium is more than a passive barrier to urine and bacteria; it actively produces bioactive compounds in response tostimuli. Moreover, recent reports [1] show that the mucosal layer exhibits phasic spontaneous contractions; not unlike detrusor or whole bladder wall (‘intact’) preparations. The purpose of this study was to investigate the pharmacology of mucosal layer contractions, testing the hypothesis that spontaneous contractions (SpC) and slow, tonic contraction are of different origin.

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CHARACTERISATION OF SPONTANEOUS CONTRACTILITY OF THE MUCOSAL LAYER OF GUINEA PIG BLADDER: COMPARISON WITH THE DETRUSOR AND INTACT BLADDER LAYERS

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