Collaborative Neuropathology Network Characterizing outcomes of TBI (CONNECT‑TBI)

Douglas Smith, Jean-Pierre Dolle, Kamar Ameen-Ali, Abigail Bretzin, Etty Cortes, John Crary, Kristen Dams-O'Connor, Ramon Diaz-Arrastia, Brian Edlow, Rebecca Folkerth, Lili-Naz Hazrati, Sidney Hinds, Diego Iacono, Victoria Johnson, Dirk Keene, Julia Kofler, Gabor Kovacs, Edward Lee, Geoffrey Manley, David MeaneyThomas Montine, David Okonkwo, Daniel Perl, John Trojanowski, Douglas Wiebe, Kristine Yaffe, Thomas McCabe, William Stewart

Research output: Contribution to journalArticlepeer-review


Efforts to characterize the late effects of traumatic brain injury (TBI) have been in progress for some time. In recent years much of this activity has been directed towards reporting of chronic traumatic encephalopathy (CTE) in former contact sports athletes and others exposed to repetitive head impacts. However, the association between TBI and dementia risk has long been acknowledged outside of contact sports. Further, growing experience suggests a complex of neurodegenerative pathologies in those surviving TBI, which extends beyond CTE. Nevertheless, despite extensive research, we have scant knowledge of the mechanisms underlying TBI-related neurodegeneration (TReND) and its link to dementia. In part, this is due to the limited number of human brain samples linked to robust demographic and clinical information available for research. Here we detail a National Institutes for Neurological Disease and Stroke Center Without Walls project, the COllaborative Neuropathology NEtwork Characterizing ouTcomes of TBI (CONNECT-TBI), designed to address current limitations in tissue and research access and to advance understanding of the neuropathologies of TReND. As an international, multidisciplinary collaboration CONNECT-TBI brings together multiple experts across 13 institutions. In so doing, CONNECT-TBI unites the existing, comprehensive clinical and neuropathological datasets of multiple established research brain archives in TBI, with survivals ranging minutes to many decades and spanning diverse injury exposures. These existing tissue specimens will be supplemented by prospective brain banking and contribute to a centralized route of access to human tissue for research for investigators. Importantly, each new case will be subject to consensus neuropathology review by the CONNECT-TBI Expert Pathology Group. Herein we set out the CONNECT-TBI program structure and aims and, by way of an illustrative case, the approach to consensus evaluation of new case donations.
Original languageEnglish
Article number32
JournalActa neuropathologica communications
Publication statusPublished - 1 Mar 2021


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