Achieving net zero emissions is a crucial challenge in the global climate change policy. It requires a substantial reduction in unabated fossil fuel use, the deployment of renewable energy sources, and the development of carbon capture, utilisation and storage technologies. The aim of this study was to investigate and compare two CO2 capture retrofits for natural gas combined cycle (NGCC). First one, amine absorption, is already mature and characterised as commercial technology, whereas second one, calcium looping is a promising method but still under pilot studies. Energy required for capture process yields net efficiency penalty, which in conducted research totalled 8.4% points for amine unit and 7.4–15.5% points in calcium-looping units. The economic evaluation was performed to analyse the impact of both concepts on their profitability. Moreover, the climate change mitigation potential was assessed and indicated that carbon capture can lower the emissivity of a conventional power plant by 82–87% or even contribute to achieving negative emissions when biofuels are used. Carbon dioxide capture is one of the key elements of ongoing energy transition and its integration with NGCC power units could be determined as essential for maintaining energy security with net zero emissions.