Abstract
Many drugs present solubility challenges which adversely affect
bioavailability
• Drug-polymer solid dispersions can improve solubility by maintaining
the drug in an amorphous state
• This study investigated computational modelling for use in preformulation studies of drug-PVP solid dispersions
• Computational modelling was able to provide insight to temperature
dependence of miscibility and to calculate key mixing parameters
bioavailability
• Drug-polymer solid dispersions can improve solubility by maintaining
the drug in an amorphous state
• This study investigated computational modelling for use in preformulation studies of drug-PVP solid dispersions
• Computational modelling was able to provide insight to temperature
dependence of miscibility and to calculate key mixing parameters
| Original language | English |
|---|---|
| Number of pages | 1 |
| Publication status | Published - 5 Sept 2016 |
| Externally published | Yes |
| Event | 7th APS International PharmSci 2016 - University of Strathclyde, Glasgow, United Kingdom Duration: 5 Sept 2016 → 7 Sept 2016 |
Conference
| Conference | 7th APS International PharmSci 2016 |
|---|---|
| Country/Territory | United Kingdom |
| City | Glasgow |
| Period | 5/09/16 → 7/09/16 |