Compatibility Screening of Drug-Polymer Blends Using Computational Modelling

T.S. Byrne; Kalliopi Dodou

Compatibility Screening of Drug-Polymer Blends Using Computational Modelling

T.S. Byrne, Kalliopi Dodou

Research output: Contribution to conference › Poster › peer-review

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Abstract

Many drugs present solubility challenges which adversely affect
bioavailability
• Drug-polymer solid dispersions can improve solubility by maintaining
the drug in an amorphous state
• This study investigated computational modelling for use in preformulation studies of drug-PVP solid dispersions
• Computational modelling was able to provide insight to temperature
dependence of miscibility and to calculate key mixing parameters

Original language	English
Number of pages	1
Publication status	Published - 5 Sept 2016
Externally published	Yes
Event	7th APS International PharmSci 2016 - University of Strathclyde, Glasgow, United Kingdom Duration: 5 Sept 2016 → 7 Sept 2016

Conference

Conference	7th APS International PharmSci 2016
Country/Territory	United Kingdom
City	Glasgow
Period	5/09/16 → 7/09/16

Access to Document

Full TextFinal published version, 875 KBLicence: CC BY-NC-ND

http://sure.sunderland.ac.uk/id/eprint/16320/Licence: CC BY-NC-ND

Cite this

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title = "Compatibility Screening of Drug-Polymer Blends Using Computational Modelling",

abstract = "Many drugs present solubility challenges which adversely affect bioavailability • Drug-polymer solid dispersions can improve solubility by maintaining the drug in an amorphous state • This study investigated computational modelling for use in preformulation studies of drug-PVP solid dispersions • Computational modelling was able to provide insight to temperature dependence of miscibility and to calculate key mixing parameters",

author = "T.S. Byrne and Kalliopi Dodou",

year = "2016",

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language = "English",

note = "7th APS International PharmSci 2016 ; Conference date: 05-09-2016 Through 07-09-2016",

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TY - CONF

T1 - Compatibility Screening of Drug-Polymer Blends Using Computational Modelling

AU - Byrne, T.S.

AU - Dodou, Kalliopi

PY - 2016/9/5

Y1 - 2016/9/5

N2 - Many drugs present solubility challenges which adversely affect bioavailability • Drug-polymer solid dispersions can improve solubility by maintaining the drug in an amorphous state • This study investigated computational modelling for use in preformulation studies of drug-PVP solid dispersions • Computational modelling was able to provide insight to temperature dependence of miscibility and to calculate key mixing parameters

AB - Many drugs present solubility challenges which adversely affect bioavailability • Drug-polymer solid dispersions can improve solubility by maintaining the drug in an amorphous state • This study investigated computational modelling for use in preformulation studies of drug-PVP solid dispersions • Computational modelling was able to provide insight to temperature dependence of miscibility and to calculate key mixing parameters

M3 - Poster

T2 - 7th APS International PharmSci 2016

Y2 - 5 September 2016 through 7 September 2016

ER -

Compatibility Screening of Drug-Polymer Blends Using Computational Modelling

Abstract

Conference

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Cite this