Competition-based quantitative chemical proteomics in breast cancer cells identifies new target profiles for sulforaphane

James A. Clulow, Elisabeth M. Storck, Thomas Lanyon-Hogg, Karunakaran Kalesh, Lyn H. Jones, Edward W. Tate

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Abstract

Sulforaphane is a small molecule isothiocyanate which exhibits anticancer potential, yet its biological targets remain poorly understood. Here we employ a competition-based chemical proteomics strategy to profile sulforaphane's targets and identify over 500 targets along with their relative affinities. These targets provide a new set of mediators for sulforaphane's bioactivity, and aid understanding of its complex mode of action.
Original languageEnglish
Pages (from-to)5182-5185
Number of pages4
JournalChemical Communications
Volume53
Issue number37
DOIs
Publication statusPublished - 25 Apr 2017
Externally publishedYes

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