Competition-based quantitative chemical proteomics in breast cancer cells identifies new target profiles for sulforaphane

James  A. Clulow; Elisabeth  M. Storck; Thomas  Lanyon-Hogg; Karunakaran Kalesh; Lyn  H. Jones; Edward  W. Tate

doi:10.1039/C6CC08797C Article type	Communication

Competition-based quantitative chemical proteomics in breast cancer cells identifies new target profiles for sulforaphane

James A. Clulow, Elisabeth M. Storck, Thomas Lanyon-Hogg, Karunakaran Kalesh, Lyn H. Jones, Edward W. Tate

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Abstract

Sulforaphane is a small molecule isothiocyanate which exhibits anticancer potential, yet its biological targets remain poorly understood. Here we employ a competition-based chemical proteomics strategy to profile sulforaphane's targets and identify over 500 targets along with their relative affinities. These targets provide a new set of mediators for sulforaphane's bioactivity, and aid understanding of its complex mode of action.

Original language	English
Pages (from-to)	5182-5185
Number of pages	4
Journal	Chemical Communications
Volume	53
Issue number	37
DOIs	https://doi.org/10.1039/C6CC08797C Article type Communication
Publication status	Published - 25 Apr 2017
Externally published	Yes

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https://pubs.rsc.org/en/content/articlelanding/2017/cc/c6cc08797cLicence: CC BY

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title = "Competition-based quantitative chemical proteomics in breast cancer cells identifies new target profiles for sulforaphane",

abstract = "Sulforaphane is a small molecule isothiocyanate which exhibits anticancer potential, yet its biological targets remain poorly understood. Here we employ a competition-based chemical proteomics strategy to profile sulforaphane's targets and identify over 500 targets along with their relative affinities. These targets provide a new set of mediators for sulforaphane's bioactivity, and aid understanding of its complex mode of action.",

author = "{A. Clulow}, James and {M. Storck}, Elisabeth and Thomas Lanyon-Hogg and Karunakaran Kalesh and {H. Jones}, Lyn and {W. Tate}, Edward",

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AU - A. Clulow, James

AU - M. Storck, Elisabeth

AU - Lanyon-Hogg, Thomas

AU - Kalesh, Karunakaran

AU - H. Jones, Lyn

AU - W. Tate, Edward

PY - 2017/4/25

Y1 - 2017/4/25

N2 - Sulforaphane is a small molecule isothiocyanate which exhibits anticancer potential, yet its biological targets remain poorly understood. Here we employ a competition-based chemical proteomics strategy to profile sulforaphane's targets and identify over 500 targets along with their relative affinities. These targets provide a new set of mediators for sulforaphane's bioactivity, and aid understanding of its complex mode of action.

AB - Sulforaphane is a small molecule isothiocyanate which exhibits anticancer potential, yet its biological targets remain poorly understood. Here we employ a competition-based chemical proteomics strategy to profile sulforaphane's targets and identify over 500 targets along with their relative affinities. These targets provide a new set of mediators for sulforaphane's bioactivity, and aid understanding of its complex mode of action.

U2 - 10.1039/C6CC08797C Article type Communication

DO - 10.1039/C6CC08797C Article type Communication

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SP - 5182

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JO - Chemical Communications

JF - Chemical Communications

IS - 37

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Competition-based quantitative chemical proteomics in breast cancer cells identifies new target profiles for sulforaphane

Abstract

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