Control of an industrial scale bioreactor using a PAT analyser

Stephen Goldrick, Ewan Mercer, Gary Montague, David Lovett, Barry Lennox

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)


This work investigates the application of a "Process Analytical Technology" (PAT) analyser to control the substrate concentration over traditional sequential batch control for an industrial scale fed-batch penicillin fermentation. A simulation that utilises the historical data from four batches, where a sequential batch control strategy was implemented, was used as the benchmark reference for this comparison. The simulation accurately predicts the main outputs variables of biomass and penicillin, given the inputs from the historical data set. The simulation includes a PAT analyser, used to build a calibration model with the available off-line substrate concentration from one of the batches. The prediction from this calibration model was used as the controlled variable within a proportional integral (PI) controller to manipulate the substrate feed rate for the three remaining batches. Performance of each control strategy was analysed by comparing the final penicillin yield of each batch. An increase of 35, 20 and 9% was observed for the three batches controlled using the PI controller compared with the sequential batch control strategy.

Original languageEnglish
Title of host publication19th IFAC World Congress IFAC 2014, Proceedings
EditorsXiaohua Xia, Edward Boje
PublisherIFAC Secretariat
Number of pages6
ISBN (Electronic)9783902823625
Publication statusPublished - 1 Jan 2014
Event19th IFAC World Congress on International Federation of Automatic Control - Cape Town, South Africa
Duration: 24 Aug 201429 Aug 2014

Publication series

NameIFAC Proceedings Volumes (IFAC-PapersOnline)
ISSN (Print)1474-6670


Conference19th IFAC World Congress on International Federation of Automatic Control
Abbreviated titleIFAC 2014
Country/TerritorySouth Africa
CityCape Town


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