Coupling desorption electrospray ionisation and neutral desorption/extractive electrospray ionisation with a travelling-wave based ion mobility mass spectrometer for the analysis of drugs

Jonathan P. Williams, James Scrivens

    Research output: Contribution to journalArticlepeer-review

    68 Citations (Scopus)

    Abstract

    Desorption electrospray ionisation (DESI) and neutral desorption/extractive electrospray ionisation (EESI) have been coupled to a hybrid quadrupole travelling-wave (T-Wave)-based ion mobility time-of-flight mass spectrometer for the direct accurate mass analysis of active ingredients formulated into pharmaceutical samples. The collision cross-section measurements of polyethylene glycol (PEG) excipients detected in one formulation were estimated and compared with published data. These estimated collision cross-sections of the PEG species showed good agreement with published data.

    Original languageEnglish
    Pages (from-to)187-196
    Number of pages10
    JournalRapid Communications in Mass Spectrometry
    Volume22
    Issue number2
    DOIs
    Publication statusPublished - 1 Feb 2008

    Fingerprint Dive into the research topics of 'Coupling desorption electrospray ionisation and neutral desorption/extractive electrospray ionisation with a travelling-wave based ion mobility mass spectrometer for the analysis of drugs'. Together they form a unique fingerprint.

    Cite this