Coupling desorption electrospray ionisation and neutral desorption/extractive electrospray ionisation with a travelling-wave based ion mobility mass spectrometer for the analysis of drugs

Jonathan P. Williams; James  Scrivens

doi:10.1002/rcm.3346

Coupling desorption electrospray ionisation and neutral desorption/extractive electrospray ionisation with a travelling-wave based ion mobility mass spectrometer for the analysis of drugs

Jonathan P. Williams, James Scrivens

Research output: Contribution to journal › Article › peer-review

68 Citations (Scopus)

Abstract

Desorption electrospray ionisation (DESI) and neutral desorption/extractive electrospray ionisation (EESI) have been coupled to a hybrid quadrupole travelling-wave (T-Wave)-based ion mobility time-of-flight mass spectrometer for the direct accurate mass analysis of active ingredients formulated into pharmaceutical samples. The collision cross-section measurements of polyethylene glycol (PEG) excipients detected in one formulation were estimated and compared with published data. These estimated collision cross-sections of the PEG species showed good agreement with published data.

Original language	English
Pages (from-to)	187-196
Number of pages	10
Journal	Rapid Communications in Mass Spectrometry
Volume	22
Issue number	2
DOIs	https://doi.org/10.1002/rcm.3346
Publication status	Published - 1 Feb 2008

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10.1002/rcm.3346

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title = "Coupling desorption electrospray ionisation and neutral desorption/extractive electrospray ionisation with a travelling-wave based ion mobility mass spectrometer for the analysis of drugs",

abstract = "Desorption electrospray ionisation (DESI) and neutral desorption/extractive electrospray ionisation (EESI) have been coupled to a hybrid quadrupole travelling-wave (T-Wave)-based ion mobility time-of-flight mass spectrometer for the direct accurate mass analysis of active ingredients formulated into pharmaceutical samples. The collision cross-section measurements of polyethylene glycol (PEG) excipients detected in one formulation were estimated and compared with published data. These estimated collision cross-sections of the PEG species showed good agreement with published data.",

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Coupling desorption electrospray ionisation and neutral desorption/extractive electrospray ionisation with a travelling-wave based ion mobility mass spectrometer for the analysis of drugs. / Williams, Jonathan P.; Scrivens, James .
In: Rapid Communications in Mass Spectrometry, Vol. 22, No. 2, 01.02.2008, p. 187-196.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

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AU - Scrivens, James

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N2 - Desorption electrospray ionisation (DESI) and neutral desorption/extractive electrospray ionisation (EESI) have been coupled to a hybrid quadrupole travelling-wave (T-Wave)-based ion mobility time-of-flight mass spectrometer for the direct accurate mass analysis of active ingredients formulated into pharmaceutical samples. The collision cross-section measurements of polyethylene glycol (PEG) excipients detected in one formulation were estimated and compared with published data. These estimated collision cross-sections of the PEG species showed good agreement with published data.

AB - Desorption electrospray ionisation (DESI) and neutral desorption/extractive electrospray ionisation (EESI) have been coupled to a hybrid quadrupole travelling-wave (T-Wave)-based ion mobility time-of-flight mass spectrometer for the direct accurate mass analysis of active ingredients formulated into pharmaceutical samples. The collision cross-section measurements of polyethylene glycol (PEG) excipients detected in one formulation were estimated and compared with published data. These estimated collision cross-sections of the PEG species showed good agreement with published data.

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DO - 10.1002/rcm.3346

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JO - Rapid Communications in Mass Spectrometry

JF - Rapid Communications in Mass Spectrometry

IS - 2

ER -

Coupling desorption electrospray ionisation and neutral desorption/extractive electrospray ionisation with a travelling-wave based ion mobility mass spectrometer for the analysis of drugs

Abstract

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